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SEMA4C (semaphorin 4C)

Identity

Alias_namesSEMAI
sema domain
Alias_symbol (synonym)Semacl1
Semaf
Other aliasM-SEMA-F
SEMACL1
SEMAF
HGNC (Hugo) SEMA4C
LocusID (NCBI) 54910
Atlas_Id 53606
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 96859736 and ends at 96869998 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SEMA4C (2q11.2) / FAM178B (2q11.2)SEMA4C (2q11.2) / PKM (15q23)SEMA4C (2q11.2) / WNT5B (12p13.33)
SEMA4C 2q11.2 / FAM178B 2q11.2SEMA4C 2q11.2 / WNT5B 12p13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(2;2)(q11;q11) SEMA4C/FAM178B
t(2;12)(q11;p13) SEMA4C/WNT5B
t(2;15)(q11;q23) SEMA4C/PKM


External links

Nomenclature
HGNC (Hugo)SEMA4C   10731
Cards
Entrez_Gene (NCBI)SEMA4C  54910  semaphorin 4C
AliasesM-SEMA-F; SEMACL1; SEMAF; SEMAI
GeneCards (Weizmann)SEMA4C
Ensembl hg19 (Hinxton)ENSG00000168758 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168758 [Gene_View]  ENSG00000168758 [Sequence]  chr2:96859736-96869998 [Contig_View]  SEMA4C [Vega]
ICGC DataPortalENSG00000168758
TCGA cBioPortalSEMA4C
AceView (NCBI)SEMA4C
Genatlas (Paris)SEMA4C
WikiGenes54910
SOURCE (Princeton)SEMA4C
Genetics Home Reference (NIH)SEMA4C
Genomic and cartography
GoldenPath hg38 (UCSC)SEMA4C  -     chr2:96859736-96869998 -  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SEMA4C  -     15q26.1   [Description]    (hg19-Feb_2009)
EnsemblSEMA4C - 15q26.1 [CytoView hg19]  SEMA4C - 15q26.1 [CytoView hg38]
Mapping of homologs : NCBISEMA4C [Mapview hg19]  SEMA4C [Mapview hg38]
OMIM604462   
Gene and transcription
Genbank (Entrez)AB051526 AF258577 AF370374 AK000376 AK075388
RefSeq transcript (Entrez)NM_017789
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SEMA4C
Cluster EST : UnigeneHs.516220 [ NCBI ]
CGAP (NCI)Hs.516220
Alternative Splicing GalleryENSG00000168758
Gene ExpressionSEMA4C [ NCBI-GEO ]   SEMA4C [ EBI - ARRAY_EXPRESS ]   SEMA4C [ SEEK ]   SEMA4C [ MEM ]
Gene Expression Viewer (FireBrowse)SEMA4C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54910
GTEX Portal (Tissue expression)SEMA4C
Human Protein AtlasENSG00000168758-SEMA4C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C0C4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C0C4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C0C4
Splice isoforms : SwissVarQ9C0C4
PhosPhoSitePlusQ9C0C4
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    SEMA (PS51004)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Plexin_repeat    PSI    Semap_dom    Semap_dom_sf    Semaphorin    WD40/YVTN_repeat-like_dom_sf   
Domain families : Pfam (Sanger)PSI (PF01437)    Sema (PF01403)   
Domain families : Pfam (NCBI)pfam01437    pfam01403   
Domain families : Smart (EMBL)IG (SM00409)  PSI (SM00423)  Sema (SM00630)  
Conserved Domain (NCBI)SEMA4C
DMDM Disease mutations54910
Blocks (Seattle)SEMA4C
SuperfamilyQ9C0C4
Human Protein Atlas [tissue]ENSG00000168758-SEMA4C [tissue]
Peptide AtlasQ9C0C4
HPRD07257
IPIIPI00073763   IPI00435974   IPI00383179   IPI00926910   IPI00924493   
Protein Interaction databases
DIP (DOE-UCLA)Q9C0C4
IntAct (EBI)Q9C0C4
FunCoupENSG00000168758
BioGRIDSEMA4C
STRING (EMBL)SEMA4C
ZODIACSEMA4C
Ontologies - Pathways
QuickGOQ9C0C4
Ontology : AmiGOneural crest cell migration  neural tube closure  protein binding  extracellular space  extracellular space  integral component of plasma membrane  postsynaptic density  integral component of membrane  cell migration in hindbrain  cerebellum development  cell junction  semaphorin receptor binding  positive regulation of cell migration  synaptic vesicle membrane  positive regulation of stress-activated MAPK cascade  neuropilin binding  muscle cell differentiation  postsynaptic membrane  chemorepellent activity  negative regulation of axon extension involved in axon guidance  negative chemotaxis  semaphorin-plexin signaling pathway  semaphorin-plexin signaling pathway  
Ontology : EGO-EBIneural crest cell migration  neural tube closure  protein binding  extracellular space  extracellular space  integral component of plasma membrane  postsynaptic density  integral component of membrane  cell migration in hindbrain  cerebellum development  cell junction  semaphorin receptor binding  positive regulation of cell migration  synaptic vesicle membrane  positive regulation of stress-activated MAPK cascade  neuropilin binding  muscle cell differentiation  postsynaptic membrane  chemorepellent activity  negative regulation of axon extension involved in axon guidance  negative chemotaxis  semaphorin-plexin signaling pathway  semaphorin-plexin signaling pathway  
Pathways : KEGGAxon guidance   
NDEx NetworkSEMA4C
Atlas of Cancer Signalling NetworkSEMA4C
Wikipedia pathwaysSEMA4C
Orthology - Evolution
OrthoDB54910
GeneTree (enSembl)ENSG00000168758
Phylogenetic Trees/Animal Genes : TreeFamSEMA4C
HOVERGENQ9C0C4
HOGENOMQ9C0C4
Homologs : HomoloGeneSEMA4C
Homology/Alignments : Family Browser (UCSC)SEMA4C
Gene fusions - Rearrangements
Fusion : MitelmanSEMA4C/FAM178B [2q11.2/2q11.2]  
Fusion : MitelmanSEMA4C/PKM [2q11.2/15q23]  [t(2;15)(q11;q23)]  
Fusion : MitelmanSEMA4C/WNT5B [2q11.2/12p13.33]  [t(2;12)(q11;p13)]  
Fusion PortalSEMA4C 2q11.2 FAM178B 2q11.2 LUSC
Fusion PortalSEMA4C 2q11.2 WNT5B 12p13.33 BRCA
Fusion : QuiverSEMA4C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSEMA4C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SEMA4C
dbVarSEMA4C
ClinVarSEMA4C
1000_GenomesSEMA4C 
Exome Variant ServerSEMA4C
ExAC (Exome Aggregation Consortium)ENSG00000168758
GNOMAD BrowserENSG00000168758
Varsome BrowserSEMA4C
Genetic variants : HAPMAP54910
Genomic Variants (DGV)SEMA4C [DGVbeta]
DECIPHERSEMA4C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSEMA4C 
Mutations
ICGC Data PortalSEMA4C 
TCGA Data PortalSEMA4C 
Broad Tumor PortalSEMA4C
OASIS PortalSEMA4C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSEMA4C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSEMA4C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SEMA4C
DgiDB (Drug Gene Interaction Database)SEMA4C
DoCM (Curated mutations)SEMA4C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SEMA4C (select a term)
intoGenSEMA4C
Cancer3DSEMA4C(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604462   
Orphanet
DisGeNETSEMA4C
MedgenSEMA4C
Genetic Testing Registry SEMA4C
NextProtQ9C0C4 [Medical]
TSGene54910
GENETestsSEMA4C
Target ValidationSEMA4C
Huge Navigator SEMA4C [HugePedia]
snp3D : Map Gene to Disease54910
BioCentury BCIQSEMA4C
ClinGenSEMA4C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54910
Chemical/Pharm GKB GenePA35653
Clinical trialSEMA4C
Miscellaneous
canSAR (ICR)SEMA4C (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSEMA4C
EVEXSEMA4C
GoPubMedSEMA4C
iHOPSEMA4C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jul 30 15:14:46 CEST 2018

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