Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SEMA6A (semaphorin 6A)

Identity

Alias_namesSEMAQ
sema domain
Alias_symbol (synonym)KIAA1368
SEMA6A1
SEMA
HT018
Other aliasVIA
HGNC (Hugo) SEMA6A
LocusID (NCBI) 57556
Atlas_Id 55554
Location 5q23.1  [Link to chromosome band 5q23]
Location_base_pair Starts at 115779251 and ends at 115910622 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BCLAF1 (6q23.3) / SEMA6A (5q23.1)NDST1 (5q33.1) / SEMA6A (5q23.1)SEMA6A (5q23.1) / DLG5 (10q22.3)
SEMA6A (5q23.1) / DOCK10 (2q36.2)SEMA6A (5q23.1) / DTWD2 (5q23.1)SEMA6A (5q23.1) / ELOF1 (19p13.2)
SEMA6A (5q23.1) / LSM6 (4q31.22)SEMA6A (5q23.1) / TEAD1 (11p15.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SEMA6A   10738
Cards
Entrez_Gene (NCBI)SEMA6A  57556  semaphorin 6A
AliasesHT018; SEMA; SEMA6A1; SEMAQ; 
VIA
GeneCards (Weizmann)SEMA6A
Ensembl hg19 (Hinxton)ENSG00000092421 [Gene_View]  chr5:115779251-115910622 [Contig_View]  SEMA6A [Vega]
Ensembl hg38 (Hinxton)ENSG00000092421 [Gene_View]  chr5:115779251-115910622 [Contig_View]  SEMA6A [Vega]
ICGC DataPortalENSG00000092421
TCGA cBioPortalSEMA6A
AceView (NCBI)SEMA6A
Genatlas (Paris)SEMA6A
WikiGenes57556
SOURCE (Princeton)SEMA6A
Genetics Home Reference (NIH)SEMA6A
Genomic and cartography
GoldenPath hg19 (UCSC)SEMA6A  -     chr5:115779251-115910622 -  5q23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SEMA6A  -     5q23.1   [Description]    (hg38-Dec_2013)
EnsemblSEMA6A - 5q23.1 [CytoView hg19]  SEMA6A - 5q23.1 [CytoView hg38]
Mapping of homologs : NCBISEMA6A [Mapview hg19]  SEMA6A [Mapview hg38]
OMIM605885   
Gene and transcription
Genbank (Entrez)AB037789 AF225425 AF279656 AI110626 AK027439
RefSeq transcript (Entrez)NM_001300780 NM_020681 NM_020796
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_034772 NW_004929323
Consensus coding sequences : CCDS (NCBI)SEMA6A
Cluster EST : UnigeneHs.156967 [ NCBI ]
CGAP (NCI)Hs.156967
Alternative Splicing GalleryENSG00000092421
Gene ExpressionSEMA6A [ NCBI-GEO ]   SEMA6A [ EBI - ARRAY_EXPRESS ]   SEMA6A [ SEEK ]   SEMA6A [ MEM ]
Gene Expression Viewer (FireBrowse)SEMA6A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57556
GTEX Portal (Tissue expression)SEMA6A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H2E6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H2E6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H2E6
Splice isoforms : SwissVarQ9H2E6
PhosPhoSitePlusQ9H2E6
Domaine pattern : Prosite (Expaxy)SEMA (PS51004)   
Domains : Interpro (EBI)Plexin-like_fold    Plexin_repeat    Semap_dom    Semaphorin    WD40/YVTN_repeat-like_dom   
Domain families : Pfam (Sanger)PSI (PF01437)    Sema (PF01403)   
Domain families : Pfam (NCBI)pfam01437    pfam01403   
Domain families : Smart (EMBL)PSI (SM00423)  Sema (SM00630)  
Conserved Domain (NCBI)SEMA6A
DMDM Disease mutations57556
Blocks (Seattle)SEMA6A
SuperfamilyQ9H2E6
Human Protein AtlasENSG00000092421
Peptide AtlasQ9H2E6
HPRD06906
IPIIPI00240598   IPI00002211   IPI00976763   IPI00010245   IPI00965029   IPI00965642   IPI00966590   IPI00965850   
Protein Interaction databases
DIP (DOE-UCLA)Q9H2E6
IntAct (EBI)Q9H2E6
FunCoupENSG00000092421
BioGRIDSEMA6A
STRING (EMBL)SEMA6A
ZODIACSEMA6A
Ontologies - Pathways
QuickGOQ9H2E6
Ontology : AmiGOneural crest cell migration  protein binding  integral component of plasma membrane  apoptotic process  cytoskeleton organization  cell surface receptor signaling pathway  nervous system development  axon guidance  organ morphogenesis  integral component of membrane  semaphorin receptor binding  axon  chemorepellent activity  negative regulation of axon extension involved in axon guidance  negative chemotaxis  semaphorin-plexin signaling pathway  positive regulation of neuron migration  
Ontology : EGO-EBIneural crest cell migration  protein binding  integral component of plasma membrane  apoptotic process  cytoskeleton organization  cell surface receptor signaling pathway  nervous system development  axon guidance  organ morphogenesis  integral component of membrane  semaphorin receptor binding  axon  chemorepellent activity  negative regulation of axon extension involved in axon guidance  negative chemotaxis  semaphorin-plexin signaling pathway  positive regulation of neuron migration  
Pathways : KEGGAxon guidance   
NDEx NetworkSEMA6A
Atlas of Cancer Signalling NetworkSEMA6A
Wikipedia pathwaysSEMA6A
Orthology - Evolution
OrthoDB57556
GeneTree (enSembl)ENSG00000092421
Phylogenetic Trees/Animal Genes : TreeFamSEMA6A
HOVERGENQ9H2E6
HOGENOMQ9H2E6
Homologs : HomoloGeneSEMA6A
Homology/Alignments : Family Browser (UCSC)SEMA6A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSEMA6A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SEMA6A
dbVarSEMA6A
ClinVarSEMA6A
1000_GenomesSEMA6A 
Exome Variant ServerSEMA6A
ExAC (Exome Aggregation Consortium)SEMA6A (select the gene name)
Genetic variants : HAPMAP57556
Genomic Variants (DGV)SEMA6A [DGVbeta]
DECIPHER (Syndromes)5:115779251-115910622  ENSG00000092421
CONAN: Copy Number AnalysisSEMA6A 
Mutations
ICGC Data PortalSEMA6A 
TCGA Data PortalSEMA6A 
Broad Tumor PortalSEMA6A
OASIS PortalSEMA6A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSEMA6A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSEMA6A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SEMA6A
DgiDB (Drug Gene Interaction Database)SEMA6A
DoCM (Curated mutations)SEMA6A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SEMA6A (select a term)
intoGenSEMA6A
Cancer3DSEMA6A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605885   
Orphanet
MedgenSEMA6A
Genetic Testing Registry SEMA6A
NextProtQ9H2E6 [Medical]
TSGene57556
GENETestsSEMA6A
Huge Navigator SEMA6A [HugePedia]
snp3D : Map Gene to Disease57556
BioCentury BCIQSEMA6A
ClinGenSEMA6A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57556
Chemical/Pharm GKB GenePA35660
Clinical trialSEMA6A
Miscellaneous
canSAR (ICR)SEMA6A (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSEMA6A
EVEXSEMA6A
GoPubMedSEMA6A
iHOPSEMA6A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:26:39 CET 2017

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