SEMA7A (semaphorin 7A (John Milton Hagen blood group))

2017-10-01  

Identity

HGNC
SEMA7A
LOCATION
15q24.1
LOCUSID
8482
ALIAS
CD108,CDw108,H-SEMA-K1,H-Sema-L,JMH,SEMAK1,SEMAL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8482
MIM: 607961
HGNC: 10741
Ensembl: ENSG00000138623

Variants:

dbSNP: 8482
ClinVar: 8482
TCGA: ENSG00000138623
COSMIC: SEMA7A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138623ENST00000261918O75326
ENSG00000138623ENST00000542748F5GYX3
ENSG00000138623ENST00000543145O75326

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Other semaphorin interactionsREACTOMER-HSA-416700

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
207275752010Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1.57
121932282002Sema7A is a potent monocyte stimulator.46
231664992012Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP.35
176715192008Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins.28
228913412012Endothelial Semaphorin 7A promotes neutrophil migration during hypoxia.23
243335362014Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines.23
193188062009The semaphorin 7A receptor Plexin C1 is lost during melanoma metastasis.22
270653362016Semaphorin 7a exerts pleiotropic effects to promote breast tumor progression.18
238500822013Semaphorin 7A contributes to TGF-β-mediated liver fibrogenesis.16
163721362006Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women.12

Citation

Dessen P

SEMA7A (semaphorin 7A (John Milton Hagen blood group))

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57180/sema7a