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SEMA7A (semaphorin 7A (John Milton Hagen blood group))

Identity

Alias_namesSEMAL
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group)
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Alias_symbol (synonym)H-Sema-L
CD108
Other aliasCDw108
H-SEMA-K1
JMH
SEMAK1
HGNC (Hugo) SEMA7A
LocusID (NCBI) 8482
Atlas_Id 73115
Location 15q24.1  [Link to chromosome band 15q24]
Location_base_pair Starts at 74409284 and ends at 74433959 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARHGEF11 (1q23.1) / SEMA7A (15q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SEMA7A   10741
LRG (Locus Reference Genomic)LRG_818
Cards
Entrez_Gene (NCBI)SEMA7A  8482  semaphorin 7A (John Milton Hagen blood group)
AliasesCD108; CDw108; H-SEMA-K1; H-Sema-L; 
JMH; SEMAK1; SEMAL
GeneCards (Weizmann)SEMA7A
Ensembl hg19 (Hinxton)ENSG00000138623 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138623 [Gene_View]  chr15:74409284-74433959 [Contig_View]  SEMA7A [Vega]
ICGC DataPortalENSG00000138623
TCGA cBioPortalSEMA7A
AceView (NCBI)SEMA7A
Genatlas (Paris)SEMA7A
WikiGenes8482
SOURCE (Princeton)SEMA7A
Genetics Home Reference (NIH)SEMA7A
Genomic and cartography
GoldenPath hg38 (UCSC)SEMA7A  -     chr15:74409284-74433959 -  15q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SEMA7A  -     15q24.1   [Description]    (hg19-Feb_2009)
EnsemblSEMA7A - 15q24.1 [CytoView hg19]  SEMA7A - 15q24.1 [CytoView hg38]
Mapping of homologs : NCBISEMA7A [Mapview hg19]  SEMA7A [Mapview hg38]
OMIM607961   614745   
Gene and transcription
Genbank (Entrez)AF030698 AF069493 AF071542 AI972833 AK001895
RefSeq transcript (Entrez)NM_001146029 NM_001146030 NM_003612
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SEMA7A
Cluster EST : UnigeneHs.24640 [ NCBI ]
CGAP (NCI)Hs.24640
Alternative Splicing GalleryENSG00000138623
Gene ExpressionSEMA7A [ NCBI-GEO ]   SEMA7A [ EBI - ARRAY_EXPRESS ]   SEMA7A [ SEEK ]   SEMA7A [ MEM ]
Gene Expression Viewer (FireBrowse)SEMA7A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8482
GTEX Portal (Tissue expression)SEMA7A
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75326   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75326  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75326
Splice isoforms : SwissVarO75326
PhosPhoSitePlusO75326
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    SEMA (PS51004)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Plexin_repeat    PSI    Semap_dom    Semaphorin    WD40/YVTN_repeat-like_dom   
Domain families : Pfam (Sanger)Ig_2 (PF13895)    PSI (PF01437)    Sema (PF01403)   
Domain families : Pfam (NCBI)pfam13895    pfam01437    pfam01403   
Domain families : Smart (EMBL)PSI (SM00423)  Sema (SM00630)  
Conserved Domain (NCBI)SEMA7A
DMDM Disease mutations8482
Blocks (Seattle)SEMA7A
PDB (SRS)3NVQ   
PDB (PDBSum)3NVQ   
PDB (IMB)3NVQ   
PDB (RSDB)3NVQ   
Structural Biology KnowledgeBase3NVQ   
SCOP (Structural Classification of Proteins)3NVQ   
CATH (Classification of proteins structures)3NVQ   
SuperfamilyO75326
Human Protein AtlasENSG00000138623
Peptide AtlasO75326
HPRD07081
IPIIPI00025257   IPI00924680   IPI00925507   
Protein Interaction databases
DIP (DOE-UCLA)O75326
IntAct (EBI)O75326
FunCoupENSG00000138623
BioGRIDSEMA7A
STRING (EMBL)SEMA7A
ZODIACSEMA7A
Ontologies - Pathways
QuickGOO75326
Ontology : AmiGOosteoblast differentiation  integrin binding  protein binding  plasma membrane  inflammatory response  immune response  integrin-mediated signaling pathway  external side of plasma membrane  membrane  olfactory lobe development  anchored component of membrane  positive regulation of axon extension  axon extension  regulation of inflammatory response  positive regulation of macrophage cytokine production  positive regulation of ERK1 and ERK2 cascade  
Ontology : EGO-EBIosteoblast differentiation  integrin binding  protein binding  plasma membrane  inflammatory response  immune response  integrin-mediated signaling pathway  external side of plasma membrane  membrane  olfactory lobe development  anchored component of membrane  positive regulation of axon extension  axon extension  regulation of inflammatory response  positive regulation of macrophage cytokine production  positive regulation of ERK1 and ERK2 cascade  
Pathways : KEGGAxon guidance   
NDEx NetworkSEMA7A
Atlas of Cancer Signalling NetworkSEMA7A
Wikipedia pathwaysSEMA7A
Orthology - Evolution
OrthoDB8482
GeneTree (enSembl)ENSG00000138623
Phylogenetic Trees/Animal Genes : TreeFamSEMA7A
HOVERGENO75326
HOGENOMO75326
Homologs : HomoloGeneSEMA7A
Homology/Alignments : Family Browser (UCSC)SEMA7A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSEMA7A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SEMA7A
dbVarSEMA7A
ClinVarSEMA7A
1000_GenomesSEMA7A 
Exome Variant ServerSEMA7A
ExAC (Exome Aggregation Consortium)SEMA7A (select the gene name)
Genetic variants : HAPMAP8482
Genomic Variants (DGV)SEMA7A [DGVbeta]
DECIPHERSEMA7A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSEMA7A 
Mutations
ICGC Data PortalSEMA7A 
TCGA Data PortalSEMA7A 
Broad Tumor PortalSEMA7A
OASIS PortalSEMA7A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSEMA7A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSEMA7A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SEMA7A
DgiDB (Drug Gene Interaction Database)SEMA7A
DoCM (Curated mutations)SEMA7A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SEMA7A (select a term)
intoGenSEMA7A
Cancer3DSEMA7A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607961    614745   
Orphanet
MedgenSEMA7A
Genetic Testing Registry SEMA7A
NextProtO75326 [Medical]
TSGene8482
GENETestsSEMA7A
Target ValidationSEMA7A
Huge Navigator SEMA7A [HugePedia]
snp3D : Map Gene to Disease8482
BioCentury BCIQSEMA7A
ClinGenSEMA7A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8482
Chemical/Pharm GKB GenePA35663
Clinical trialSEMA7A
Miscellaneous
canSAR (ICR)SEMA7A (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSEMA7A
EVEXSEMA7A
GoPubMedSEMA7A
iHOPSEMA7A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:37:32 CEST 2017

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