SEMG1 (semenogelin 1)

2007-02-01  

Identity

HGNC
LOCATION
20q13.12
LOCUSID
ALIAS
CT103,SEMG,SGI,dJ172H20.2

Other Information

Locus ID:

NCBI: 6406
MIM: 182140
HGNC: 10742
Ensembl: ENSG00000124233

Variants:

dbSNP: 6406
ClinVar: 6406
TCGA: ENSG00000124233
COSMIC: SEMG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124233ENST00000372781P04279

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
221775592011Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection.74
176830362007Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide?43
146290362003Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen.25
187140132008The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.22
155909012005Association of eppin with semenogelin on human spermatozoa.21
122004572002Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues.20
198899472010Analysis of recombinant human semenogelin as an inhibitor of human sperm motility.18
146139012004Involvement of semenogelin-derived peptides in the antibacterial activity of human seminal plasma.15
155637302005Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen.14
184829842008Major role of human KLK14 in seminal clot liquefaction.12

Citation

Dessen P

SEMG1 (semenogelin 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46426/semg1