SEMG2 (semenogelin 2)

2011-08-01  

Identity

HGNC
LOCATION
20q13.12
LOCUSID
ALIAS
SGII

Other Information

Locus ID:

NCBI: 6407
MIM: 182141
HGNC: 10743
Ensembl: ENSG00000124157

Variants:

dbSNP: 6407
ClinVar: 6407
TCGA: ENSG00000124157
COSMIC: SEMG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124157ENST00000372769Q02383

Expression (GTEx)

0
1

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
221775592011Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection.74
176830362007Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide?43
146290362003Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen.25
187140132008The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.22
122004572002Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues.20
155637302005Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen.14
184829842008Major role of human KLK14 in seminal clot liquefaction.12
145815142003Quantification of seminal plasma motility inhibitor/semenogelin in human seminal plasma.10
215572752011Expression of semenogelins I and II and its prognostic significance in human prostate cancer.9
190899432009Functional implications of membrane modification with semenogelins for inhibition of sperm motility in humans.6

Citation

Dessen P

SEMG2 (semenogelin 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52311/semg2