SENP1 (SUMO specific peptidase 1)

2003-06-01 Affiliation

Identity

HGNC

SENP1

LOCATION

12q13.11

LOCUSID

29843

ALIAS

SuPr-2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 29843
MIM: 612157
HGNC: 17927
Ensembl: ENSG00000079387

Variants:

dbSNP: 29843
ClinVar: 29843
TCGA: ENSG00000079387
COSMIC: SENP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000079387	ENST00000448372	Q9P0U3
ENSG00000079387	ENST00000549518	Q9P0U3
ENSG00000079387	ENST00000549595	Q9P0U3
ENSG00000079387	ENST00000551798	F8VRZ8
ENSG00000079387	ENST00000552189	F8W0I8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
SUMOylation	REACTOME	R-HSA-2990846
Processing and activation of SUMO	REACTOME	R-HSA-3215018
SUMO is proteolytically processed	REACTOME	R-HSA-3065679

References

Pubmed ID	Year	Title	Citations
16925949	2006	Role of desumoylation in the development of prostate cancer.	73
15199155	2004	SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1.	59
16553580	2006	The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.	47
17704192	2008	Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation.	47
17099698	2006	SUMO protease SENP1 induces isomerization of the scissile peptide bond.	43
19116244	2009	SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells.	43
26389676	2015	Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.	42
23633483	2013	SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function.	38
22733136	2013	SUMO-specific protease 1 promotes prostate cancer progression and metastasis.	37
12466471	2002	Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease.	32

Citation

Dessen P

SENP1 (SUMO specific peptidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42258/senp1