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SENP1 (SUMO specific peptidase 1)

Identity

Alias_namesSUMO1/sentrin specific protease 1
Other aliasSuPr-2
HGNC (Hugo) SENP1
LocusID (NCBI) 29843
Atlas_Id 42258
Location 12q13.11  [Link to chromosome band 12q13]
Location_base_pair Starts at 48042898 and ends at 48105992 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SENP1 (12q13.11) / ILF3 (19p13.2)SENP1 (12q13.11) / MESDC2 (15q25.1)SENP1 (12q13.11) / MSRB3 (12q14.3)
SENP1 (12q13.11) / SENP1 (12q13.11)SENP1 (12q13.11) / SPDYA (2p23.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SENP1   17927
Cards
Entrez_Gene (NCBI)SENP1  29843  SUMO specific peptidase 1
AliasesSuPr-2
GeneCards (Weizmann)SENP1
Ensembl hg19 (Hinxton)ENSG00000079387 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000079387 [Gene_View]  ENSG00000079387 [Sequence]  chr12:48042898-48105992 [Contig_View]  SENP1 [Vega]
ICGC DataPortalENSG00000079387
TCGA cBioPortalSENP1
AceView (NCBI)SENP1
Genatlas (Paris)SENP1
WikiGenes29843
SOURCE (Princeton)SENP1
Genetics Home Reference (NIH)SENP1
Genomic and cartography
GoldenPath hg38 (UCSC)SENP1  -     chr12:48042898-48105992 -  12q13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SENP1  -     12q13.11   [Description]    (hg19-Feb_2009)
EnsemblSENP1 - 12q13.11 [CytoView hg19]  SENP1 - 12q13.11 [CytoView hg38]
Mapping of homologs : NCBISENP1 [Mapview hg19]  SENP1 [Mapview hg38]
OMIM612157   
Gene and transcription
Genbank (Entrez)AF149770 AK292060 AK312874 AL582855 BC045639
RefSeq transcript (Entrez)NM_001267594 NM_001267595 NM_014554
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SENP1
Cluster EST : UnigeneHs.371957 [ NCBI ]
CGAP (NCI)Hs.371957
Alternative Splicing GalleryENSG00000079387
Gene ExpressionSENP1 [ NCBI-GEO ]   SENP1 [ EBI - ARRAY_EXPRESS ]   SENP1 [ SEEK ]   SENP1 [ MEM ]
Gene Expression Viewer (FireBrowse)SENP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29843
GTEX Portal (Tissue expression)SENP1
Human Protein AtlasENSG00000079387-SENP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P0U3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P0U3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P0U3
Splice isoforms : SwissVarQ9P0U3
PhosPhoSitePlusQ9P0U3
Domaine pattern : Prosite (Expaxy)ULP_PROTEASE (PS50600)   
Domains : Interpro (EBI)Peptidase_C48_C   
Domain families : Pfam (Sanger)Peptidase_C48 (PF02902)   
Domain families : Pfam (NCBI)pfam02902   
Conserved Domain (NCBI)SENP1
DMDM Disease mutations29843
Blocks (Seattle)SENP1
PDB (SRS)2CKG    2CKH    2G4D    2IY0    2IY1    2IYC    2IYD    2XPH    2XRE   
PDB (PDBSum)2CKG    2CKH    2G4D    2IY0    2IY1    2IYC    2IYD    2XPH    2XRE   
PDB (IMB)2CKG    2CKH    2G4D    2IY0    2IY1    2IYC    2IYD    2XPH    2XRE   
PDB (RSDB)2CKG    2CKH    2G4D    2IY0    2IY1    2IYC    2IYD    2XPH    2XRE   
Structural Biology KnowledgeBase2CKG    2CKH    2G4D    2IY0    2IY1    2IYC    2IYD    2XPH    2XRE   
SCOP (Structural Classification of Proteins)2CKG    2CKH    2G4D    2IY0    2IY1    2IYC    2IYD    2XPH    2XRE   
CATH (Classification of proteins structures)2CKG    2CKH    2G4D    2IY0    2IY1    2IYC    2IYD    2XPH    2XRE   
SuperfamilyQ9P0U3
Human Protein Atlas [tissue]ENSG00000079387-SENP1 [tissue]
Peptide AtlasQ9P0U3
HPRD07153
IPIIPI00914975   IPI00005101   IPI00418148   IPI01021563   IPI01021719   
Protein Interaction databases
DIP (DOE-UCLA)Q9P0U3
IntAct (EBI)Q9P0U3
FunCoupENSG00000079387
BioGRIDSENP1
STRING (EMBL)SENP1
ZODIACSENP1
Ontologies - Pathways
QuickGOQ9P0U3
Ontology : AmiGOendopeptidase activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  focal adhesion  proteolysis  activation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of definitive erythrocyte differentiation  protein sumoylation  protein desumoylation  protein desumoylation  nuclear membrane  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of transcription by RNA polymerase II  SUMO-specific endopeptidase activity  SUMO-specific isopeptidase activity  apoptotic signaling pathway  
Ontology : EGO-EBIendopeptidase activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  focal adhesion  proteolysis  activation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of definitive erythrocyte differentiation  protein sumoylation  protein desumoylation  protein desumoylation  nuclear membrane  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of transcription by RNA polymerase II  SUMO-specific endopeptidase activity  SUMO-specific isopeptidase activity  apoptotic signaling pathway  
NDEx NetworkSENP1
Atlas of Cancer Signalling NetworkSENP1
Wikipedia pathwaysSENP1
Orthology - Evolution
OrthoDB29843
GeneTree (enSembl)ENSG00000079387
Phylogenetic Trees/Animal Genes : TreeFamSENP1
HOVERGENQ9P0U3
HOGENOMQ9P0U3
Homologs : HomoloGeneSENP1
Homology/Alignments : Family Browser (UCSC)SENP1
Gene fusions - Rearrangements
Fusion : QuiverSENP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSENP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SENP1
dbVarSENP1
ClinVarSENP1
1000_GenomesSENP1 
Exome Variant ServerSENP1
ExAC (Exome Aggregation Consortium)ENSG00000079387
GNOMAD BrowserENSG00000079387
Varsome BrowserSENP1
Genetic variants : HAPMAP29843
Genomic Variants (DGV)SENP1 [DGVbeta]
DECIPHERSENP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSENP1 
Mutations
ICGC Data PortalSENP1 
TCGA Data PortalSENP1 
Broad Tumor PortalSENP1
OASIS PortalSENP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSENP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSENP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SENP1
DgiDB (Drug Gene Interaction Database)SENP1
DoCM (Curated mutations)SENP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SENP1 (select a term)
intoGenSENP1
Cancer3DSENP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612157   
Orphanet
DisGeNETSENP1
MedgenSENP1
Genetic Testing Registry SENP1
NextProtQ9P0U3 [Medical]
TSGene29843
GENETestsSENP1
Target ValidationSENP1
Huge Navigator SENP1 [HugePedia]
snp3D : Map Gene to Disease29843
BioCentury BCIQSENP1
ClinGenSENP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29843
Chemical/Pharm GKB GenePA134947038
Clinical trialSENP1
Miscellaneous
canSAR (ICR)SENP1 (select the gene name)
Probes
Litterature
PubMed107 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSENP1
EVEXSENP1
GoPubMedSENP1
iHOPSENP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:38:10 CET 2018

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