SENP2 (SUMO specific peptidase 2)

2013-05-01 Affiliation

Identity

HGNC

SENP2

LOCATION

3q27.2

LOCUSID

59343

ALIAS

AXAM2,SMT3IP2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 59343
MIM: 608261
HGNC: 23116
Ensembl: ENSG00000163904

Variants:

dbSNP: 59343
ClinVar: 59343
TCGA: ENSG00000163904
COSMIC: SENP2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000163904	ENST00000296257	Q9HC62
ENSG00000163904	ENST00000413407	F8WED7
ENSG00000163904	ENST00000430355	C9IYB7
ENSG00000163904	ENST00000439684	F8WCX8
ENSG00000163904	ENST00000444509	H7C1A0
ENSG00000163904	ENST00000453532	F8WET6
ENSG00000163904	ENST00000458551	F8WED6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Wnt signaling pathway	KEGG	ko04310
Wnt signaling pathway	KEGG	hsa04310
RNA transport	KEGG	ko03013
RNA transport	KEGG	hsa03013
Nuclear pore complex	KEGG	hsa_M00427
Nuclear pore complex	KEGG	M00427
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
SUMOylation	REACTOME	R-HSA-2990846
Processing and activation of SUMO	REACTOME	R-HSA-3215018
SUMO is proteolytically processed	REACTOME	R-HSA-3065679

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
11896061	2002	Association of the human SUMO-1 protease SENP2 with the nuclear pore.	86
17099700	2006	Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates.	56
16738331	2006	Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2.	36
21777808	2011	NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress.	32
22028379	2011	SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation.	28
25689261	2015	Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function.	28
21183956	2011	SUMO-specific protease 2 in Mdm2-mediated regulation of p53.	27
22031293	2011	The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex.	24
24048451	2013	SENP1 and SENP2 affect spatial and temporal control of sumoylation in mitosis.	20
22155005	2012	Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.	19

Citation

Dessen P

SENP2 (SUMO specific peptidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53271/senp2