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SENP2 (SUMO1/sentrin/SMT3 specific peptidase 2)

Identity

Alias_namesSUMO1/sentrin/SMT3 specific protease 2
Alias_symbol (synonym)SMT3IP2
KIAA1331
DKFZp762A2316
AXAM2
Other alias
HGNC (Hugo) SENP2
LocusID (NCBI) 59343
Atlas_Id 53271
Location 3q27.2  [Link to chromosome band 3q27]
Location_base_pair Starts at 185586243 and ends at 185631097 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PLPPR4 (1p21.2) / SENP2 (3q27.2)SENP2 (3q27.2) / ANKRD27 (19q13.11)SENP2 (3q27.2) / CLCN2 (3q27.1)
SENP2 (3q27.2) / WASF1 (6q21)SENP2 3q27.2 / ANKRD27 19q13.11SENP2 3q27.2 / CLCN2 3q27.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SENP2   23116
Cards
Entrez_Gene (NCBI)SENP2  59343  SUMO1/sentrin/SMT3 specific peptidase 2
AliasesAXAM2; SMT3IP2
GeneCards (Weizmann)SENP2
Ensembl hg19 (Hinxton)ENSG00000163904 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163904 [Gene_View]  chr3:185586243-185631097 [Contig_View]  SENP2 [Vega]
ICGC DataPortalENSG00000163904
TCGA cBioPortalSENP2
AceView (NCBI)SENP2
Genatlas (Paris)SENP2
WikiGenes59343
SOURCE (Princeton)SENP2
Genetics Home Reference (NIH)SENP2
Genomic and cartography
GoldenPath hg38 (UCSC)SENP2  -     chr3:185586243-185631097 +  3q27.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SENP2  -     3q27.2   [Description]    (hg19-Feb_2009)
EnsemblSENP2 - 3q27.2 [CytoView hg19]  SENP2 - 3q27.2 [CytoView hg38]
Mapping of homologs : NCBISENP2 [Mapview hg19]  SENP2 [Mapview hg38]
OMIM608261   
Gene and transcription
Genbank (Entrez)AF151697 AK027599 AK074357 AK296744 AK296772
RefSeq transcript (Entrez)NM_021627
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SENP2
Cluster EST : UnigeneHs.401388 [ NCBI ]
CGAP (NCI)Hs.401388
Alternative Splicing GalleryENSG00000163904
Gene ExpressionSENP2 [ NCBI-GEO ]   SENP2 [ EBI - ARRAY_EXPRESS ]   SENP2 [ SEEK ]   SENP2 [ MEM ]
Gene Expression Viewer (FireBrowse)SENP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)59343
GTEX Portal (Tissue expression)SENP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HC62   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HC62  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HC62
Splice isoforms : SwissVarQ9HC62
Catalytic activity : Enzyme3.4.22.68 [ Enzyme-Expasy ]   3.4.22.683.4.22.68 [ IntEnz-EBI ]   3.4.22.68 [ BRENDA ]   3.4.22.68 [ KEGG ]   
PhosPhoSitePlusQ9HC62
Domaine pattern : Prosite (Expaxy)ULP_PROTEASE (PS50600)   
Domains : Interpro (EBI)Peptidase_C48_C   
Domain families : Pfam (Sanger)Peptidase_C48 (PF02902)   
Domain families : Pfam (NCBI)pfam02902   
Conserved Domain (NCBI)SENP2
DMDM Disease mutations59343
Blocks (Seattle)SENP2
PDB (SRS)1TGZ    1TH0    2IO0    2IO1    2IO2    2IO3    3ZO5    5AEK   
PDB (PDBSum)1TGZ    1TH0    2IO0    2IO1    2IO2    2IO3    3ZO5    5AEK   
PDB (IMB)1TGZ    1TH0    2IO0    2IO1    2IO2    2IO3    3ZO5    5AEK   
PDB (RSDB)1TGZ    1TH0    2IO0    2IO1    2IO2    2IO3    3ZO5    5AEK   
Structural Biology KnowledgeBase1TGZ    1TH0    2IO0    2IO1    2IO2    2IO3    3ZO5    5AEK   
SCOP (Structural Classification of Proteins)1TGZ    1TH0    2IO0    2IO1    2IO2    2IO3    3ZO5    5AEK   
CATH (Classification of proteins structures)1TGZ    1TH0    2IO0    2IO1    2IO2    2IO3    3ZO5    5AEK   
SuperfamilyQ9HC62
Human Protein AtlasENSG00000163904
Peptide AtlasQ9HC62
HPRD07002
IPIIPI00794410   IPI00939143   IPI00307683   IPI01009718   IPI00925195   IPI00924932   IPI00924721   IPI00924460   IPI00924453   
Protein Interaction databases
DIP (DOE-UCLA)Q9HC62
IntAct (EBI)Q9HC62
FunCoupENSG00000163904
BioGRIDSENP2
STRING (EMBL)SENP2
ZODIACSENP2
Ontologies - Pathways
QuickGOQ9HC62
Ontology : AmiGOpositive regulation of protein phosphorylation  endopeptidase activity  protein binding  nuclear pore  nucleoplasm  cytosol  heart development  dorsal/ventral axis specification  protein transport  Wnt signaling pathway  PML body  protein sumoylation  protein desumoylation  protein desumoylation  SUMO-specific protease activity  protein domain specific binding  regulation of Wnt signaling pathway  negative regulation of protein ubiquitination  positive regulation of protein ubiquitination  cytoplasmic vesicle  protein destabilization  nuclear membrane  negative regulation of protein binding  regulation of DNA endoreduplication  negative regulation of chromatin binding  negative regulation of DNA damage response, signal transduction by p53 class mediator  fat cell differentiation  positive regulation of transcription from RNA polymerase II promoter  mRNA transport  trophoblast giant cell differentiation  labyrinthine layer development  spongiotrophoblast layer development  SUMO-specific endopeptidase activity  regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  endopeptidase activity  protein binding  nuclear pore  nucleoplasm  cytosol  heart development  dorsal/ventral axis specification  protein transport  Wnt signaling pathway  PML body  protein sumoylation  protein desumoylation  protein desumoylation  SUMO-specific protease activity  protein domain specific binding  regulation of Wnt signaling pathway  negative regulation of protein ubiquitination  positive regulation of protein ubiquitination  cytoplasmic vesicle  protein destabilization  nuclear membrane  negative regulation of protein binding  regulation of DNA endoreduplication  negative regulation of chromatin binding  negative regulation of DNA damage response, signal transduction by p53 class mediator  fat cell differentiation  positive regulation of transcription from RNA polymerase II promoter  mRNA transport  trophoblast giant cell differentiation  labyrinthine layer development  spongiotrophoblast layer development  SUMO-specific endopeptidase activity  regulation of G1/S transition of mitotic cell cycle  
Pathways : KEGGRNA transport    Wnt signaling pathway   
NDEx NetworkSENP2
Atlas of Cancer Signalling NetworkSENP2
Wikipedia pathwaysSENP2
Orthology - Evolution
OrthoDB59343
GeneTree (enSembl)ENSG00000163904
Phylogenetic Trees/Animal Genes : TreeFamSENP2
HOVERGENQ9HC62
HOGENOMQ9HC62
Homologs : HomoloGeneSENP2
Homology/Alignments : Family Browser (UCSC)SENP2
Gene fusions - Rearrangements
Fusion : MitelmanSENP2/ANKRD27 [3q27.2/19q13.11]  
Fusion : MitelmanSENP2/CLCN2 [3q27.2/3q27.1]  [t(3;3)(q27;q27)]  
Fusion: TCGASENP2 3q27.2 ANKRD27 19q13.11 LUSC
Fusion: TCGASENP2 3q27.2 CLCN2 3q27.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSENP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SENP2
dbVarSENP2
ClinVarSENP2
1000_GenomesSENP2 
Exome Variant ServerSENP2
ExAC (Exome Aggregation Consortium)SENP2 (select the gene name)
Genetic variants : HAPMAP59343
Genomic Variants (DGV)SENP2 [DGVbeta]
DECIPHERSENP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSENP2 
Mutations
ICGC Data PortalSENP2 
TCGA Data PortalSENP2 
Broad Tumor PortalSENP2
OASIS PortalSENP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSENP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSENP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SENP2
DgiDB (Drug Gene Interaction Database)SENP2
DoCM (Curated mutations)SENP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SENP2 (select a term)
intoGenSENP2
Cancer3DSENP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608261   
Orphanet
MedgenSENP2
Genetic Testing Registry SENP2
NextProtQ9HC62 [Medical]
TSGene59343
GENETestsSENP2
Target ValidationSENP2
Huge Navigator SENP2 [HugePedia]
snp3D : Map Gene to Disease59343
BioCentury BCIQSENP2
ClinGenSENP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD59343
Chemical/Pharm GKB GenePA134955185
Clinical trialSENP2
Miscellaneous
canSAR (ICR)SENP2 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSENP2
EVEXSENP2
GoPubMedSENP2
iHOPSENP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:30:28 CEST 2017

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