SENP5 (SUMO specific peptidase 5)

2009-01-01  

Identity

HGNC
LOCATION
3q29
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 205564
MIM: 612845
HGNC: 28407
Ensembl: ENSG00000119231

Variants:

dbSNP: 205564
ClinVar: 205564
TCGA: ENSG00000119231
COSMIC: SENP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119231ENST00000323460Q96HI0
ENSG00000119231ENST00000419026C9JHT8
ENSG00000119231ENST00000434433H7C424
ENSG00000119231ENST00000445299Q96HI0
ENSG00000119231ENST00000448068H7C2F8

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
Processing and activation of SUMOREACTOMER-HSA-3215018
SUMO is proteolytically processedREACTOMER-HSA-3065679

References

Pubmed IDYearTitleCitations
167383152006The SUMO-specific protease SENP5 is required for cell division.69
190153142008Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases.39
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.17
189493992008Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation.12
246581612014SENP5 mediates breast cancer invasion via a TGFβRI SUMOylation cascade.10
259014142015Sentrin/small ubiquitin-like modifier-specific protease 5 protects oral cancer cells from oxidative stress-induced apoptosis.2

Citation

Dessen P

SENP5 (SUMO specific peptidase 5)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50626/senp5