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SENP6 (SUMO specific peptidase 6)

Identity

Alias (NCBI)SSP1
SUSP1
HGNC (Hugo) SENP6
HGNC Alias symbSUSP1
KIAA0797
HGNC Previous nameSUMO1/sentrin specific protease 6
 SUMO1/sentrin specific peptidase 6
LocusID (NCBI) 26054
Atlas_Id 42259
Location 6q14.1  [Link to chromosome band 6q14]
Location_base_pair Starts at 75601880 and ends at 75718281 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FGF12 (3q28) / SENP6 (6q14.1)HOXD1 (2q31.1) / SENP6 (6q14.1)MYO6 (6q14.1) / SENP6 (6q14.1)
NKAIN2 (6q22.31) / SENP6 (6q14.1)RPL14 (3p22.1) / SENP6 (6q14.1)SENP6 (6q14.1) / ADGRA2 (8p11.23)
SENP6 (6q14.1) / HMP19 (5q35.2)SENP6 (6q14.1) / NKAIN2 (6q22.31)SENP6 (6q14.1) / OOEP (6q13)
SENP6 (6q14.1) / PDK1 (2q31.1)SENP6 (6q14.1) / SENP6 (6q14.1)SENP6 (6q14.1) / SLC35A1 (6q15)
SENP6 (6q14.1) / TOP1 (20q12)ZNF544 (19q13.43) / SENP6 (6q14.1)MYO6 6q14.1 / SENP6 6q14.1
SENP6 6q14.1 GPR124SENP6 6q14.1 / OOEP 6q13SENP6 6q14.1 / SLC35A1 6q15
ZNF544 19q13.43 / SENP6 6q14.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q14;q21) SENP6/NKAIN2

External links

 

Nomenclature
HGNC (Hugo)SENP6   20944
Cards
Entrez_Gene (NCBI)SENP6    SUMO specific peptidase 6
AliasesSSP1; SUSP1
GeneCards (Weizmann)SENP6
Ensembl hg19 (Hinxton)ENSG00000112701 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112701 [Gene_View]  ENSG00000112701 [Sequence]  chr6:75601880-75718281 [Contig_View]  SENP6 [Vega]
ICGC DataPortalENSG00000112701
TCGA cBioPortalSENP6
AceView (NCBI)SENP6
Genatlas (Paris)SENP6
SOURCE (Princeton)SENP6
Genetics Home Reference (NIH)SENP6
Genomic and cartography
GoldenPath hg38 (UCSC)SENP6  -     chr6:75601880-75718281 +  6q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SENP6  -     6q14.1   [Description]    (hg19-Feb_2009)
GoldenPathSENP6 - 6q14.1 [CytoView hg19]  SENP6 - 6q14.1 [CytoView hg38]
ImmunoBaseENSG00000112701
Genome Data Viewer NCBISENP6 [Mapview hg19]  
OMIM605003   
Gene and transcription
Genbank (Entrez)AA768785 AB018340 AF196304 AF306508 AF307849
RefSeq transcript (Entrez)NM_001100409 NM_001304792 NM_015571
Consensus coding sequences : CCDS (NCBI)SENP6
Gene ExpressionSENP6 [ NCBI-GEO ]   SENP6 [ EBI - ARRAY_EXPRESS ]   SENP6 [ SEEK ]   SENP6 [ MEM ]
Gene Expression Viewer (FireBrowse)SENP6 [ Firebrowse - Broad ]
GenevisibleExpression of SENP6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26054
GTEX Portal (Tissue expression)SENP6
Human Protein AtlasENSG00000112701-SENP6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9GZR1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9GZR1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9GZR1
PhosPhoSitePlusQ9GZR1
Domaine pattern : Prosite (Expaxy)ULP_PROTEASE (PS50600)   
Domains : Interpro (EBI)Papain-like_cys_pep_sf    Peptidase_C48_C   
Domain families : Pfam (Sanger)Peptidase_C48 (PF02902)   
Domain families : Pfam (NCBI)pfam02902   
Conserved Domain (NCBI)SENP6
SuperfamilyQ9GZR1
AlphaFold pdb e-kbQ9GZR1   
Human Protein Atlas [tissue]ENSG00000112701-SENP6 [tissue]
HPRD05417
Protein Interaction databases
DIP (DOE-UCLA)Q9GZR1
IntAct (EBI)Q9GZR1
BioGRIDSENP6
STRING (EMBL)SENP6
ZODIACSENP6
Ontologies - Pathways
QuickGOQ9GZR1
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytoplasm  cytosol  protein sumoylation  protein desumoylation  protein desumoylation  SUMO-specific endopeptidase activity  SUMO-specific endopeptidase activity  protein modification by small protein removal  regulation of spindle assembly  regulation of spindle assembly  regulation of kinetochore assembly  regulation of kinetochore assembly  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytoplasm  cytosol  protein sumoylation  protein desumoylation  protein desumoylation  SUMO-specific endopeptidase activity  SUMO-specific endopeptidase activity  protein modification by small protein removal  regulation of spindle assembly  regulation of spindle assembly  regulation of kinetochore assembly  regulation of kinetochore assembly  
NDEx NetworkSENP6
Atlas of Cancer Signalling NetworkSENP6
Wikipedia pathwaysSENP6
Orthology - Evolution
OrthoDB26054
GeneTree (enSembl)ENSG00000112701
Phylogenetic Trees/Animal Genes : TreeFamSENP6
Homologs : HomoloGeneSENP6
Homology/Alignments : Family Browser (UCSC)SENP6
Gene fusions - Rearrangements
Fusion : MitelmanMYO6/SENP6 [6q14.1/6q14.1]  
Fusion : MitelmanSENP6/ADGRA2 [6q14.1/8p11.23]  
Fusion : MitelmanSENP6/NKAIN2 [6q14.1/6q22.31]  
Fusion : MitelmanSENP6/OOEP [6q14.1/6q13]  
Fusion : MitelmanSENP6/SLC35A1 [6q14.1/6q15]  
Fusion : MitelmanZNF544/SENP6 [19q13.43/6q14.1]  
Fusion : QuiverSENP6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSENP6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SENP6
dbVarSENP6
ClinVarSENP6
MonarchSENP6
1000_GenomesSENP6 
Exome Variant ServerSENP6
GNOMAD BrowserENSG00000112701
Varsome BrowserSENP6
ACMGSENP6 variants
VarityQ9GZR1
Genomic Variants (DGV)SENP6 [DGVbeta]
DECIPHERSENP6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSENP6 
Mutations
ICGC Data PortalSENP6 
TCGA Data PortalSENP6 
Broad Tumor PortalSENP6
OASIS PortalSENP6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSENP6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSENP6
Mutations and Diseases : HGMDSENP6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSENP6
DgiDB (Drug Gene Interaction Database)SENP6
DoCM (Curated mutations)SENP6
CIViC (Clinical Interpretations of Variants in Cancer)SENP6
Cancer3DSENP6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605003   
Orphanet
DisGeNETSENP6
MedgenSENP6
Genetic Testing Registry SENP6
NextProtQ9GZR1 [Medical]
GENETestsSENP6
Target ValidationSENP6
Huge Navigator SENP6 [HugePedia]
ClinGenSENP6
Clinical trials, drugs, therapy
MyCancerGenomeSENP6
Protein Interactions : CTDSENP6
Pharm GKB GenePA134893291
PharosQ9GZR1
Clinical trialSENP6
Miscellaneous
canSAR (ICR)SENP6
HarmonizomeSENP6
DataMed IndexSENP6
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSENP6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:30:34 CEST 2021
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