Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SENP6 (SUMO specific peptidase 6)

Identity

Alias_namesSUMO1/sentrin specific protease 6
Alias_symbol (synonym)SUSP1
KIAA0797
Other aliasSSP1
HGNC (Hugo) SENP6
LocusID (NCBI) 26054
Atlas_Id 42259
Location 6q14.1  [Link to chromosome band 6q14]
Location_base_pair Starts at 75601509 and ends at 75718285 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FGF12 (3q28) / SENP6 (6q14.1)HOXD1 (2q31.1) / SENP6 (6q14.1)MYO6 (6q14.1) / SENP6 (6q14.1)
NKAIN2 (6q22.31) / SENP6 (6q14.1)RPL14 (3p22.1) / SENP6 (6q14.1)SENP6 (6q14.1) / ADGRA2 (8p11.23)
SENP6 (6q14.1) / HMP19 (5q35.2)SENP6 (6q14.1) / NKAIN2 (6q22.31)SENP6 (6q14.1) / OOEP (6q13)
SENP6 (6q14.1) / PDK1 (2q31.1)SENP6 (6q14.1) / SENP6 (6q14.1)SENP6 (6q14.1) / SLC35A1 (6q15)
SENP6 (6q14.1) / TOP1 (20q12)ZNF544 (19q13.43) / SENP6 (6q14.1)MYO6 6q14.1 / SENP6 6q14.1
SENP6 6q14.1 GPR124SENP6 6q14.1 / OOEP 6q13SENP6 6q14.1 / SLC35A1 6q15
ZNF544 19q13.43 / SENP6 6q14.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q14;q21) SENP6/NKAIN2

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(6;6)(q13;q14) SENP6/OOEP
MYO6/SENP6 (6q14)
MYO6/SENP6 (6q14)
t(6;6)(q14;q15) SENP6/SLC35A1
t(6;8)(q14;p11) SENP6/ADGRA2
t(6;19)(q14;q13) ZNF544/SENP6

External links

Nomenclature
HGNC (Hugo)SENP6   20944
Cards
Entrez_Gene (NCBI)SENP6  26054  SUMO specific peptidase 6
AliasesSSP1; SUSP1
GeneCards (Weizmann)SENP6
Ensembl hg19 (Hinxton)ENSG00000112701 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112701 [Gene_View]  ENSG00000112701 [Sequence]  chr6:75601509-75718285 [Contig_View]  SENP6 [Vega]
ICGC DataPortalENSG00000112701
TCGA cBioPortalSENP6
AceView (NCBI)SENP6
Genatlas (Paris)SENP6
WikiGenes26054
SOURCE (Princeton)SENP6
Genetics Home Reference (NIH)SENP6
Genomic and cartography
GoldenPath hg38 (UCSC)SENP6  -     chr6:75601509-75718285 +  6q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SENP6  -     6q14.1   [Description]    (hg19-Feb_2009)
EnsemblSENP6 - 6q14.1 [CytoView hg19]  SENP6 - 6q14.1 [CytoView hg38]
Mapping of homologs : NCBISENP6 [Mapview hg19]  SENP6 [Mapview hg38]
OMIM605003   
Gene and transcription
Genbank (Entrez)AA768785 AB018340 AF196304 AF306508 AF307849
RefSeq transcript (Entrez)NM_001100409 NM_001304792 NM_015571
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SENP6
Cluster EST : UnigeneHs.485784 [ NCBI ]
CGAP (NCI)Hs.485784
Alternative Splicing GalleryENSG00000112701
Gene ExpressionSENP6 [ NCBI-GEO ]   SENP6 [ EBI - ARRAY_EXPRESS ]   SENP6 [ SEEK ]   SENP6 [ MEM ]
Gene Expression Viewer (FireBrowse)SENP6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26054
GTEX Portal (Tissue expression)SENP6
Human Protein AtlasENSG00000112701-SENP6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9GZR1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9GZR1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9GZR1
Splice isoforms : SwissVarQ9GZR1
PhosPhoSitePlusQ9GZR1
Domaine pattern : Prosite (Expaxy)ULP_PROTEASE (PS50600)   
Domains : Interpro (EBI)Peptidase_C48_C   
Domain families : Pfam (Sanger)Peptidase_C48 (PF02902)   
Domain families : Pfam (NCBI)pfam02902   
Conserved Domain (NCBI)SENP6
DMDM Disease mutations26054
Blocks (Seattle)SENP6
SuperfamilyQ9GZR1
Human Protein Atlas [tissue]ENSG00000112701-SENP6 [tissue]
Peptide AtlasQ9GZR1
HPRD05417
IPIIPI00023586   IPI00747900   IPI00967649   IPI00967175   IPI00941249   IPI01010921   IPI00966088   IPI00965389   IPI00965131   
Protein Interaction databases
DIP (DOE-UCLA)Q9GZR1
IntAct (EBI)Q9GZR1
FunCoupENSG00000112701
BioGRIDSENP6
STRING (EMBL)SENP6
ZODIACSENP6
Ontologies - Pathways
QuickGOQ9GZR1
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytoplasm  cytosol  protein sumoylation  protein desumoylation  protein desumoylation  SUMO-specific endopeptidase activity  SUMO-specific endopeptidase activity  protein modification by small protein removal  regulation of spindle assembly  regulation of spindle assembly  regulation of kinetochore assembly  regulation of kinetochore assembly  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytoplasm  cytosol  protein sumoylation  protein desumoylation  protein desumoylation  SUMO-specific endopeptidase activity  SUMO-specific endopeptidase activity  protein modification by small protein removal  regulation of spindle assembly  regulation of spindle assembly  regulation of kinetochore assembly  regulation of kinetochore assembly  
NDEx NetworkSENP6
Atlas of Cancer Signalling NetworkSENP6
Wikipedia pathwaysSENP6
Orthology - Evolution
OrthoDB26054
GeneTree (enSembl)ENSG00000112701
Phylogenetic Trees/Animal Genes : TreeFamSENP6
HOGENOMQ9GZR1
Homologs : HomoloGeneSENP6
Homology/Alignments : Family Browser (UCSC)SENP6
Gene fusions - Rearrangements
Fusion : MitelmanMYO6/SENP6 [6q14.1/6q14.1]  [t(6;6)(q14;q14)]  
Fusion : MitelmanSENP6/ADGRA2 [6q14.1/8p11.23]  [t(6;8)(q14;p11)]  
Fusion : MitelmanSENP6/NKAIN2 [6q14.1/6q22.31]  [t(6;6)(q14;q21)]  
Fusion : MitelmanSENP6/OOEP [6q14.1/6q13]  [t(6;6)(q13;q14)]  
Fusion : MitelmanSENP6/SLC35A1 [6q14.1/6q15]  [t(6;6)(q14;q15)]  
Fusion : MitelmanZNF544/SENP6 [19q13.43/6q14.1]  [t(6;19)(q14;q13)]  
Fusion PortalMYO6 6q14.1 SENP6 6q14.1 BRCA HNSC LUAD
Fusion PortalSENP6 6q14.1 GPR124 BRCA
Fusion PortalSENP6 6q14.1 OOEP 6q13 PRAD
Fusion PortalSENP6 6q14.1 SLC35A1 6q15 BRCA
Fusion PortalZNF544 19q13.43 SENP6 6q14.1 BRCA
Fusion : QuiverSENP6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSENP6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SENP6
dbVarSENP6
ClinVarSENP6
1000_GenomesSENP6 
Exome Variant ServerSENP6
ExAC (Exome Aggregation Consortium)ENSG00000112701
GNOMAD BrowserENSG00000112701
Varsome BrowserSENP6
Genetic variants : HAPMAP26054
Genomic Variants (DGV)SENP6 [DGVbeta]
DECIPHERSENP6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSENP6 
Mutations
ICGC Data PortalSENP6 
TCGA Data PortalSENP6 
Broad Tumor PortalSENP6
OASIS PortalSENP6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSENP6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSENP6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SENP6
DgiDB (Drug Gene Interaction Database)SENP6
DoCM (Curated mutations)SENP6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SENP6 (select a term)
intoGenSENP6
Cancer3DSENP6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605003   
Orphanet
DisGeNETSENP6
MedgenSENP6
Genetic Testing Registry SENP6
NextProtQ9GZR1 [Medical]
TSGene26054
GENETestsSENP6
Target ValidationSENP6
Huge Navigator SENP6 [HugePedia]
snp3D : Map Gene to Disease26054
BioCentury BCIQSENP6
ClinGenSENP6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26054
Chemical/Pharm GKB GenePA134893291
Clinical trialSENP6
Miscellaneous
canSAR (ICR)SENP6 (select the gene name)
DataMed IndexSENP6
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSENP6
EVEXSENP6
GoPubMedSENP6
iHOPSENP6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:37:18 CET 2019
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