Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SEPHS1 (selenophosphate synthetase 1)

Identity

Alias_nameswater dikinase
Alias_symbol (synonym)SPS
SPS1
Other aliasSELD
HGNC (Hugo) SEPHS1
LocusID (NCBI) 22929
Atlas_Id 46214
Location 10p13  [Link to chromosome band 10p13]
Location_base_pair Starts at 13317438 and ends at 13348298 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SEPHS1   19685
Cards
Entrez_Gene (NCBI)SEPHS1  22929  selenophosphate synthetase 1
AliasesSELD; SPS; SPS1
GeneCards (Weizmann)SEPHS1
Ensembl hg19 (Hinxton)ENSG00000086475 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000086475 [Gene_View]  chr10:13317438-13348298 [Contig_View]  SEPHS1 [Vega]
ICGC DataPortalENSG00000086475
TCGA cBioPortalSEPHS1
AceView (NCBI)SEPHS1
Genatlas (Paris)SEPHS1
WikiGenes22929
SOURCE (Princeton)SEPHS1
Genetics Home Reference (NIH)SEPHS1
Genomic and cartography
GoldenPath hg38 (UCSC)SEPHS1  -     chr10:13317438-13348298 -  10p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SEPHS1  -     10p13   [Description]    (hg19-Feb_2009)
EnsemblSEPHS1 - 10p13 [CytoView hg19]  SEPHS1 - 10p13 [CytoView hg38]
Mapping of homologs : NCBISEPHS1 [Mapview hg19]  SEPHS1 [Mapview hg38]
OMIM600902   
Gene and transcription
Genbank (Entrez)AK125066 AK297129 AK301568 AK309829 AL557595
RefSeq transcript (Entrez)NM_001195602 NM_001195604 NM_012247
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SEPHS1
Cluster EST : UnigeneHs.124027 [ NCBI ]
CGAP (NCI)Hs.124027
Alternative Splicing GalleryENSG00000086475
Gene ExpressionSEPHS1 [ NCBI-GEO ]   SEPHS1 [ EBI - ARRAY_EXPRESS ]   SEPHS1 [ SEEK ]   SEPHS1 [ MEM ]
Gene Expression Viewer (FireBrowse)SEPHS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22929
GTEX Portal (Tissue expression)SEPHS1
Human Protein AtlasENSG00000086475-SEPHS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49903   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49903  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49903
Splice isoforms : SwissVarP49903
Catalytic activity : Enzyme2.7.9.3 [ Enzyme-Expasy ]   2.7.9.32.7.9.3 [ IntEnz-EBI ]   2.7.9.3 [ BRENDA ]   2.7.9.3 [ KEGG ]   
PhosPhoSitePlusP49903
Domains : Interpro (EBI)AIR_synth_C_dom    PurM-like_N    SPS/SelD   
Domain families : Pfam (Sanger)AIRS (PF00586)    AIRS_C (PF02769)   
Domain families : Pfam (NCBI)pfam00586    pfam02769   
Conserved Domain (NCBI)SEPHS1
DMDM Disease mutations22929
Blocks (Seattle)SEPHS1
PDB (SRS)3FD5    3FD6   
PDB (PDBSum)3FD5    3FD6   
PDB (IMB)3FD5    3FD6   
PDB (RSDB)3FD5    3FD6   
Structural Biology KnowledgeBase3FD5    3FD6   
SCOP (Structural Classification of Proteins)3FD5    3FD6   
CATH (Classification of proteins structures)3FD5    3FD6   
SuperfamilyP49903
Human Protein Atlas [tissue]ENSG00000086475-SEPHS1 [tissue]
Peptide AtlasP49903
HPRD02944
IPIIPI00029056   IPI01013430   IPI00980968   IPI00640051   IPI00640517   IPI00644973   
Protein Interaction databases
DIP (DOE-UCLA)P49903
IntAct (EBI)P49903
FunCoupENSG00000086475
BioGRIDSEPHS1
STRING (EMBL)SEPHS1
ZODIACSEPHS1
Ontologies - Pathways
QuickGOP49903
Ontology : AmiGOselenide, water dikinase activity  protein binding  ATP binding  GTP binding  cytoplasm  plasma membrane  cellular protein modification process  phosphorylation  nuclear membrane  identical protein binding  
Ontology : EGO-EBIselenide, water dikinase activity  protein binding  ATP binding  GTP binding  cytoplasm  plasma membrane  cellular protein modification process  phosphorylation  nuclear membrane  identical protein binding  
Pathways : KEGGSelenocompound metabolism   
NDEx NetworkSEPHS1
Atlas of Cancer Signalling NetworkSEPHS1
Wikipedia pathwaysSEPHS1
Orthology - Evolution
OrthoDB22929
GeneTree (enSembl)ENSG00000086475
Phylogenetic Trees/Animal Genes : TreeFamSEPHS1
HOVERGENP49903
HOGENOMP49903
Homologs : HomoloGeneSEPHS1
Homology/Alignments : Family Browser (UCSC)SEPHS1
Gene fusions - Rearrangements
Tumor Fusion PortalSEPHS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSEPHS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SEPHS1
dbVarSEPHS1
ClinVarSEPHS1
1000_GenomesSEPHS1 
Exome Variant ServerSEPHS1
ExAC (Exome Aggregation Consortium)ENSG00000086475
GNOMAD BrowserENSG00000086475
Genetic variants : HAPMAP22929
Genomic Variants (DGV)SEPHS1 [DGVbeta]
DECIPHERSEPHS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSEPHS1 
Mutations
ICGC Data PortalSEPHS1 
TCGA Data PortalSEPHS1 
Broad Tumor PortalSEPHS1
OASIS PortalSEPHS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSEPHS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSEPHS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SEPHS1
DgiDB (Drug Gene Interaction Database)SEPHS1
DoCM (Curated mutations)SEPHS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SEPHS1 (select a term)
intoGenSEPHS1
Cancer3DSEPHS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600902   
Orphanet
DisGeNETSEPHS1
MedgenSEPHS1
Genetic Testing Registry SEPHS1
NextProtP49903 [Medical]
TSGene22929
GENETestsSEPHS1
Target ValidationSEPHS1
Huge Navigator SEPHS1 [HugePedia]
snp3D : Map Gene to Disease22929
BioCentury BCIQSEPHS1
ClinGenSEPHS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22929
Chemical/Pharm GKB GenePA134905215
Clinical trialSEPHS1
Miscellaneous
canSAR (ICR)SEPHS1 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSEPHS1
EVEXSEPHS1
GoPubMedSEPHS1
iHOPSEPHS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:34:02 CET 2017

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