SEPHS1 (selenophosphate synthetase 1)

2007-02-01  

Identity

HGNC
LOCATION
10p13
LOCUSID
ALIAS
SELD,SPS,SPS1

Other Information

Locus ID:

NCBI: 22929
MIM: 600902
HGNC: 19685
Ensembl: ENSG00000086475

Variants:

dbSNP: 22929
ClinVar: 22929
TCGA: ENSG00000086475
COSMIC: SEPHS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000086475ENST00000327347P49903
ENSG00000086475ENST00000378614P49903
ENSG00000086475ENST00000413411Q5T5U6
ENSG00000086475ENST00000425947Q5T5U7
ENSG00000086475ENST00000545675P49903

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Selenocompound metabolismKEGGko00450
Selenocompound metabolismKEGGhsa00450
Metabolic pathwaysKEGGhsa01100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
155342302004Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation.21
231129132012Selenium, selenoprotein genes and Crohn's disease in a case-control population from Auckland, New Zealand.13
204719582010Human selenophosphate synthetase 1 has five splice variants with unique interactions, subcellular localizations and expression patterns.6
167865702006p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression.4
284144602017Analysis of Novel Interactions between Components of the Selenocysteine Biosynthesis Pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43.2

Citation

Dessen P

SEPHS1 (selenophosphate synthetase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46214/sephs1