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SERGEF (secretion regulating guanine nucleotide exchange factor)

Identity

Alias (NCBI)DELGEF
Gnefr
HGNC (Hugo) SERGEF
HGNC Alias symbDelGEF
Gnefr
LocusID (NCBI) 26297
Atlas_Id 54610
Location 11p15.1  [Link to chromosome band 11p15]
Location_base_pair Starts at 17788050 and ends at 18013047 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LDHC (11p15.1) / SERGEF (11p15.1)MAD1L1 (7p22.3) / SERGEF (11p15.1)MYO18A (17q11.2) / SERGEF (11p15.1)
PLEKHA7 (11p15.1) / SERGEF (11p15.1)SERGEF (11p15.1) / ANKRD29 (18q11.2)SERGEF (11p15.1) / SERGEF (11p15.1)
SERGEF (11p15.1) / TERF2IP (16q23.1)MAD1L1 7p22.3 / SERGEF 11p15.1MYO18A 17q11.2 / SERGEF 11p15.1
PLEKHA7 11p15.1 / SERGEF 11p15.1SERGEF 11p15.1 / ANKRD29 18q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SERGEF   17499
Cards
Entrez_Gene (NCBI)SERGEF    secretion regulating guanine nucleotide exchange factor
AliasesDELGEF; Gnefr
GeneCards (Weizmann)SERGEF
Ensembl hg19 (Hinxton)ENSG00000129158 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129158 [Gene_View]  ENSG00000129158 [Sequence]  chr11:17788050-18013047 [Contig_View]  SERGEF [Vega]
ICGC DataPortalENSG00000129158
TCGA cBioPortalSERGEF
AceView (NCBI)SERGEF
Genatlas (Paris)SERGEF
SOURCE (Princeton)SERGEF
Genetics Home Reference (NIH)SERGEF
Genomic and cartography
GoldenPath hg38 (UCSC)SERGEF  -     chr11:17788050-18013047 -  11p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SERGEF  -     11p15.1   [Description]    (hg19-Feb_2009)
GoldenPathSERGEF - 11p15.1 [CytoView hg19]  SERGEF - 11p15.1 [CytoView hg38]
ImmunoBaseENSG00000129158
Genome Data Viewer NCBISERGEF [Mapview hg19]  
OMIM606051   
Gene and transcription
Genbank (Entrez)AF086056 AJ243950 AJ243951 AK292286 AK294022
RefSeq transcript (Entrez)NM_012139
Consensus coding sequences : CCDS (NCBI)SERGEF
Gene ExpressionSERGEF [ NCBI-GEO ]   SERGEF [ EBI - ARRAY_EXPRESS ]   SERGEF [ SEEK ]   SERGEF [ MEM ]
Gene Expression Viewer (FireBrowse)SERGEF [ Firebrowse - Broad ]
GenevisibleExpression of SERGEF in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26297
GTEX Portal (Tissue expression)SERGEF
Human Protein AtlasENSG00000129158-SERGEF [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGK8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UGK8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UGK8
PhosPhoSitePlusQ9UGK8
Domaine pattern : Prosite (Expaxy)RCC1_2 (PS00626)    RCC1_3 (PS50012)   
Domains : Interpro (EBI)RCC1/BLIP-II    Reg_chr_condens   
Domain families : Pfam (Sanger)RCC1 (PF00415)   
Domain families : Pfam (NCBI)pfam00415   
Conserved Domain (NCBI)SERGEF
SuperfamilyQ9UGK8
AlphaFold pdb e-kbQ9UGK8   
Human Protein Atlas [tissue]ENSG00000129158-SERGEF [tissue]
HPRD06926
Protein Interaction databases
DIP (DOE-UCLA)Q9UGK8
IntAct (EBI)Q9UGK8
BioGRIDSERGEF
STRING (EMBL)SERGEF
ZODIACSERGEF
Ontologies - Pathways
QuickGOQ9UGK8
Ontology : AmiGOguanyl-nucleotide exchange factor activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  signal transduction  negative regulation of protein secretion  regulation of catalytic activity  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  signal transduction  negative regulation of protein secretion  regulation of catalytic activity  
NDEx NetworkSERGEF
Atlas of Cancer Signalling NetworkSERGEF
Wikipedia pathwaysSERGEF
Orthology - Evolution
OrthoDB26297
GeneTree (enSembl)ENSG00000129158
Phylogenetic Trees/Animal Genes : TreeFamSERGEF
Homologs : HomoloGeneSERGEF
Homology/Alignments : Family Browser (UCSC)SERGEF
Gene fusions - Rearrangements
Fusion : MitelmanLDHC/SERGEF [11p15.1/11p15.1]  
Fusion : MitelmanMAD1L1/SERGEF [7p22.3/11p15.1]  
Fusion : MitelmanMYO18A/SERGEF [17q11.2/11p15.1]  
Fusion : MitelmanPLEKHA7/SERGEF [11p15.1/11p15.1]  
Fusion : MitelmanSERGEF/ANKRD29 [11p15.1/18q11.2]  
Fusion : QuiverSERGEF
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERGEF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERGEF
dbVarSERGEF
ClinVarSERGEF
MonarchSERGEF
1000_GenomesSERGEF 
Exome Variant ServerSERGEF
GNOMAD BrowserENSG00000129158
Varsome BrowserSERGEF
ACMGSERGEF variants
VarityQ9UGK8
Genomic Variants (DGV)SERGEF [DGVbeta]
DECIPHERSERGEF [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSERGEF 
Mutations
ICGC Data PortalSERGEF 
TCGA Data PortalSERGEF 
Broad Tumor PortalSERGEF
OASIS PortalSERGEF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERGEF  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSERGEF
Mutations and Diseases : HGMDSERGEF
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSERGEF
DgiDB (Drug Gene Interaction Database)SERGEF
DoCM (Curated mutations)SERGEF
CIViC (Clinical Interpretations of Variants in Cancer)SERGEF
Cancer3DSERGEF
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606051   
Orphanet
DisGeNETSERGEF
MedgenSERGEF
Genetic Testing Registry SERGEF
NextProtQ9UGK8 [Medical]
GENETestsSERGEF
Target ValidationSERGEF
Huge Navigator SERGEF [HugePedia]
ClinGenSERGEF
Clinical trials, drugs, therapy
MyCancerGenomeSERGEF
Protein Interactions : CTDSERGEF
Pharm GKB GenePA143485610
PharosQ9UGK8
Clinical trialSERGEF
Miscellaneous
canSAR (ICR)SERGEF
HarmonizomeSERGEF
DataMed IndexSERGEF
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSERGEF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:30:37 CEST 2021

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