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SERGEF (secretion regulating guanine nucleotide exchange factor)

Identity

Alias_symbol (synonym)DelGEF
Gnefr
Other aliasDELGEF
HGNC (Hugo) SERGEF
LocusID (NCBI) 26297
Atlas_Id 54610
Location 11p15.1  [Link to chromosome band 11p15]
Location_base_pair Starts at 17809596 and ends at 18034709 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LDHC (11p15.1) / SERGEF (11p15.1)MAD1L1 (7p22.3) / SERGEF (11p15.1)MYO18A (17q11.2) / SERGEF (11p15.1)
PLEKHA7 (11p15.1) / SERGEF (11p15.1)SERGEF (11p15.1) / ANKRD29 (18q11.2)SERGEF (11p15.1) / SERGEF (11p15.1)
SERGEF (11p15.1) / TERF2IP (16q23.1)MAD1L1 7p22.3 / SERGEF 11p15.1MYO18A 17q11.2 / SERGEF 11p15.1
PLEKHA7 11p15.1 / SERGEF 11p15.1SERGEF 11p15.1 / ANKRD29 18q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SERGEF   17499
Cards
Entrez_Gene (NCBI)SERGEF  26297  secretion regulating guanine nucleotide exchange factor
AliasesDELGEF; Gnefr
GeneCards (Weizmann)SERGEF
Ensembl hg19 (Hinxton)ENSG00000129158 [Gene_View]  chr11:17809596-18034709 [Contig_View]  SERGEF [Vega]
Ensembl hg38 (Hinxton)ENSG00000129158 [Gene_View]  chr11:17809596-18034709 [Contig_View]  SERGEF [Vega]
ICGC DataPortalENSG00000129158
TCGA cBioPortalSERGEF
AceView (NCBI)SERGEF
Genatlas (Paris)SERGEF
WikiGenes26297
SOURCE (Princeton)SERGEF
Genetics Home Reference (NIH)SERGEF
Genomic and cartography
GoldenPath hg19 (UCSC)SERGEF  -     chr11:17809596-18034709 -  11p15.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SERGEF  -     11p15.1   [Description]    (hg38-Dec_2013)
EnsemblSERGEF - 11p15.1 [CytoView hg19]  SERGEF - 11p15.1 [CytoView hg38]
Mapping of homologs : NCBISERGEF [Mapview hg19]  SERGEF [Mapview hg38]
OMIM606051   
Gene and transcription
Genbank (Entrez)AF086056 AJ243950 AJ243951 AK292286 AK294022
RefSeq transcript (Entrez)NM_012139
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)SERGEF
Cluster EST : UnigeneHs.32470 [ NCBI ]
CGAP (NCI)Hs.32470
Alternative Splicing GalleryENSG00000129158
Gene ExpressionSERGEF [ NCBI-GEO ]   SERGEF [ EBI - ARRAY_EXPRESS ]   SERGEF [ SEEK ]   SERGEF [ MEM ]
Gene Expression Viewer (FireBrowse)SERGEF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26297
GTEX Portal (Tissue expression)SERGEF
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGK8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UGK8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UGK8
Splice isoforms : SwissVarQ9UGK8
PhosPhoSitePlusQ9UGK8
Domaine pattern : Prosite (Expaxy)RCC1_2 (PS00626)    RCC1_3 (PS50012)   
Domains : Interpro (EBI)DelGEF    RCC1/BLIP-II    Reg_chr_condens   
Domain families : Pfam (Sanger)RCC1 (PF00415)   
Domain families : Pfam (NCBI)pfam00415   
Conserved Domain (NCBI)SERGEF
DMDM Disease mutations26297
Blocks (Seattle)SERGEF
SuperfamilyQ9UGK8
Human Protein AtlasENSG00000129158
Peptide AtlasQ9UGK8
HPRD06926
IPIIPI00015919   IPI00383576   IPI00983717   IPI00977685   IPI00976302   IPI00979498   IPI00982490   IPI00980170   IPI00985024   IPI00978282   IPI00983112   IPI00981864   IPI00983666   IPI00985461   IPI00981352   
Protein Interaction databases
DIP (DOE-UCLA)Q9UGK8
IntAct (EBI)Q9UGK8
FunCoupENSG00000129158
BioGRIDSERGEF
STRING (EMBL)SERGEF
ZODIACSERGEF
Ontologies - Pathways
QuickGOQ9UGK8
Ontology : AmiGORan guanyl-nucleotide exchange factor activity  protein binding  nucleus  cytoplasm  signal transduction  positive regulation of GTPase activity  positive regulation of GTPase activity  negative regulation of protein secretion  
Ontology : EGO-EBIRan guanyl-nucleotide exchange factor activity  protein binding  nucleus  cytoplasm  signal transduction  positive regulation of GTPase activity  positive regulation of GTPase activity  negative regulation of protein secretion  
NDEx NetworkSERGEF
Atlas of Cancer Signalling NetworkSERGEF
Wikipedia pathwaysSERGEF
Orthology - Evolution
OrthoDB26297
GeneTree (enSembl)ENSG00000129158
Phylogenetic Trees/Animal Genes : TreeFamSERGEF
HOVERGENQ9UGK8
HOGENOMQ9UGK8
Homologs : HomoloGeneSERGEF
Homology/Alignments : Family Browser (UCSC)SERGEF
Gene fusions - Rearrangements
Fusion : MitelmanLDHC/SERGEF [11p15.1/11p15.1]  [del(11)(p15p15)]  
Fusion : MitelmanMAD1L1/SERGEF [7p22.3/11p15.1]  [t(7;11)(p22;p15)]  
Fusion : MitelmanMYO18A/SERGEF [17q11.2/11p15.1]  [t(11;17)(p15;q11)]  
Fusion : MitelmanPLEKHA7/SERGEF [11p15.1/11p15.1]  [t(11;11)(p15;p15)]  
Fusion : MitelmanSERGEF/ANKRD29 [11p15.1/18q11.2]  [t(11;18)(p15;q11)]  
Fusion: TCGAMAD1L1 7p22.3 SERGEF 11p15.1 HNSC
Fusion: TCGAMYO18A 17q11.2 SERGEF 11p15.1 BRCA
Fusion: TCGAPLEKHA7 11p15.1 SERGEF 11p15.1 BLCA
Fusion: TCGASERGEF 11p15.1 ANKRD29 18q11.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERGEF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERGEF
dbVarSERGEF
ClinVarSERGEF
1000_GenomesSERGEF 
Exome Variant ServerSERGEF
ExAC (Exome Aggregation Consortium)SERGEF (select the gene name)
Genetic variants : HAPMAP26297
Genomic Variants (DGV)SERGEF [DGVbeta]
DECIPHER (Syndromes)11:17809596-18034709  ENSG00000129158
CONAN: Copy Number AnalysisSERGEF 
Mutations
ICGC Data PortalSERGEF 
TCGA Data PortalSERGEF 
Broad Tumor PortalSERGEF
OASIS PortalSERGEF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERGEF  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSERGEF
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SERGEF
DgiDB (Drug Gene Interaction Database)SERGEF
DoCM (Curated mutations)SERGEF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SERGEF (select a term)
intoGenSERGEF
Cancer3DSERGEF(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606051   
Orphanet
MedgenSERGEF
Genetic Testing Registry SERGEF
NextProtQ9UGK8 [Medical]
TSGene26297
GENETestsSERGEF
Huge Navigator SERGEF [HugePedia]
snp3D : Map Gene to Disease26297
BioCentury BCIQSERGEF
ClinGenSERGEF
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26297
Chemical/Pharm GKB GenePA143485610
Clinical trialSERGEF
Miscellaneous
canSAR (ICR)SERGEF (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSERGEF
EVEXSERGEF
GoPubMedSERGEF
iHOPSERGEF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:18:49 CEST 2017

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