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SERINC1 (serine incorporator 1)

Identity

Alias_namesTDE2
tumor differentially expressed 2
Alias_symbol (synonym)TMS-2
TDE1L
KIAA1253
Other aliasTMS2
HGNC (Hugo) SERINC1
LocusID (NCBI) 57515
Atlas_Id 42503
Location 6q22.31  [Link to chromosome band 6q22]
Location_base_pair Starts at 122443348 and ends at 122471881 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASCC3 (6q16.3) / SERINC1 (6q22.31)DEGS1 (1q42.11) / SERINC1 (6q22.31)GINS1 (20p11.21) / SERINC1 (6q22.31)
HSF2 (6q22.31) / SERINC1 (6q22.31)IFI6 (1p36.11) / SERINC1 (6q22.31)RPS12 (6q23.2) / SERINC1 (6q22.31)
SERINC1 (6q22.31) / MGEA5 (10q24.32)SERINC1 (6q22.31) / PALLD (4q32.3)SERINC1 (6q22.31) / SERINC1 (6q22.31)
SERINC1 (6q22.31) / SLC39A10 (2q32.3)ZC3H15 (2q32.1) / SERINC1 (6q22.31)ASCC3 6q16.3 / SERINC1 6q22.31
ZC3H15 2q32.1 / SERINC1 6q22.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(2;6)(q32;q22) ZC3H15/SERINC1
t(6;6)(q16;q22) ASCC3/SERINC1


External links

Nomenclature
HGNC (Hugo)SERINC1   13464
Cards
Entrez_Gene (NCBI)SERINC1  57515  serine incorporator 1
AliasesTDE1L; TDE2; TMS-2; TMS2
GeneCards (Weizmann)SERINC1
Ensembl hg19 (Hinxton)ENSG00000111897 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111897 [Gene_View]  ENSG00000111897 [Sequence]  chr6:122443348-122471881 [Contig_View]  SERINC1 [Vega]
ICGC DataPortalENSG00000111897
TCGA cBioPortalSERINC1
AceView (NCBI)SERINC1
Genatlas (Paris)SERINC1
WikiGenes57515
SOURCE (Princeton)SERINC1
Genetics Home Reference (NIH)SERINC1
Genomic and cartography
GoldenPath hg38 (UCSC)SERINC1  -     chr6:122443348-122471881 -  6q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SERINC1  -     6q22.31   [Description]    (hg19-Feb_2009)
EnsemblSERINC1 - 6q22.31 [CytoView hg19]  SERINC1 - 6q22.31 [CytoView hg38]
Mapping of homologs : NCBISERINC1 [Mapview hg19]  SERINC1 [Mapview hg38]
OMIM614548   
Gene and transcription
Genbank (Entrez)AB033079 AF087902 AF164794 AK075339 AL137261
RefSeq transcript (Entrez)NM_020755
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SERINC1
Cluster EST : UnigeneHs.146668 [ NCBI ]
CGAP (NCI)Hs.146668
Alternative Splicing GalleryENSG00000111897
Gene ExpressionSERINC1 [ NCBI-GEO ]   SERINC1 [ EBI - ARRAY_EXPRESS ]   SERINC1 [ SEEK ]   SERINC1 [ MEM ]
Gene Expression Viewer (FireBrowse)SERINC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57515
GTEX Portal (Tissue expression)SERINC1
Human Protein AtlasENSG00000111897-SERINC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRX5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRX5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRX5
Splice isoforms : SwissVarQ9NRX5
PhosPhoSitePlusQ9NRX5
Domains : Interpro (EBI)SERINC1    TDE1/TMS   
Domain families : Pfam (Sanger)Serinc (PF03348)   
Domain families : Pfam (NCBI)pfam03348   
Conserved Domain (NCBI)SERINC1
DMDM Disease mutations57515
Blocks (Seattle)SERINC1
SuperfamilyQ9NRX5
Human Protein Atlas [tissue]ENSG00000111897-SERINC1 [tissue]
Peptide AtlasQ9NRX5
HPRD15480
IPIIPI00413817   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRX5
IntAct (EBI)Q9NRX5
FunCoupENSG00000111897
BioGRIDSERINC1
STRING (EMBL)SERINC1
ZODIACSERINC1
Ontologies - Pathways
QuickGOQ9NRX5
Ontology : AmiGOprotein binding  endoplasmic reticulum membrane  plasma membrane  phosphatidylserine metabolic process  sphingolipid metabolic process  phospholipid biosynthetic process  integral component of membrane  enzyme binding  protein binding, bridging  membrane biogenesis  positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity  positive regulation of serine C-palmitoyltransferase activity  
Ontology : EGO-EBIprotein binding  endoplasmic reticulum membrane  plasma membrane  phosphatidylserine metabolic process  sphingolipid metabolic process  phospholipid biosynthetic process  integral component of membrane  enzyme binding  protein binding, bridging  membrane biogenesis  positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity  positive regulation of serine C-palmitoyltransferase activity  
NDEx NetworkSERINC1
Atlas of Cancer Signalling NetworkSERINC1
Wikipedia pathwaysSERINC1
Orthology - Evolution
OrthoDB57515
GeneTree (enSembl)ENSG00000111897
Phylogenetic Trees/Animal Genes : TreeFamSERINC1
HOVERGENQ9NRX5
HOGENOMQ9NRX5
Homologs : HomoloGeneSERINC1
Homology/Alignments : Family Browser (UCSC)SERINC1
Gene fusions - Rearrangements
Fusion : MitelmanASCC3/SERINC1 [6q16.3/6q22.31]  [t(6;6)(q16;q22)]  
Fusion : MitelmanZC3H15/SERINC1 [2q32.1/6q22.31]  [t(2;6)(q32;q22)]  
Fusion PortalASCC3 6q16.3 SERINC1 6q22.31 LGG
Fusion PortalZC3H15 2q32.1 SERINC1 6q22.31 PRAD
Fusion : QuiverSERINC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERINC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERINC1
dbVarSERINC1
ClinVarSERINC1
1000_GenomesSERINC1 
Exome Variant ServerSERINC1
ExAC (Exome Aggregation Consortium)ENSG00000111897
GNOMAD BrowserENSG00000111897
Varsome BrowserSERINC1
Genetic variants : HAPMAP57515
Genomic Variants (DGV)SERINC1 [DGVbeta]
DECIPHERSERINC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSERINC1 
Mutations
ICGC Data PortalSERINC1 
TCGA Data PortalSERINC1 
Broad Tumor PortalSERINC1
OASIS PortalSERINC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERINC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSERINC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SERINC1
DgiDB (Drug Gene Interaction Database)SERINC1
DoCM (Curated mutations)SERINC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SERINC1 (select a term)
intoGenSERINC1
Cancer3DSERINC1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614548   
Orphanet
DisGeNETSERINC1
MedgenSERINC1
Genetic Testing Registry SERINC1
NextProtQ9NRX5 [Medical]
TSGene57515
GENETestsSERINC1
Target ValidationSERINC1
Huge Navigator SERINC1 [HugePedia]
snp3D : Map Gene to Disease57515
BioCentury BCIQSERINC1
ClinGenSERINC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57515
Chemical/Pharm GKB GenePA134973249
Clinical trialSERINC1
Miscellaneous
canSAR (ICR)SERINC1 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSERINC1
EVEXSERINC1
GoPubMedSERINC1
iHOPSERINC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:38:16 CET 2018

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