SERINC2 (serine incorporator 2)

2003-11-01  

Identity

HGNC
LOCATION
1p35.2
LOCUSID
ALIAS
FKSG84,PRO0899,TDE2,TDE2L
FUSION GENES

Other Information

Locus ID:

NCBI: 347735
MIM: 614549
HGNC: 23231
Ensembl: ENSG00000168528

Variants:

dbSNP: 347735
ClinVar: 347735
TCGA: ENSG00000168528
COSMIC: SERINC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168528ENST00000373709Q96SA4
ENSG00000168528ENST00000373710Q96SA4
ENSG00000168528ENST00000536384Q96SA4
ENSG00000168528ENST00000536859Q96SA4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614
Serine biosynthesisREACTOMER-HSA-977347

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
217528292011Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.263
234554912013NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.17
244245052014siRNA-mediated knockdown of hTDE2 retards cell cycle progression through transcriptional activation of p21.1
237783222013Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent.0
289359722017Chromosomal microarray analysis in a cohort of underrepresented population identifies SERINC2 as a novel candidate gene for autism spectrum disorder.0
292680822018Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5.0

Citation

Dessen P

SERINC2 (serine incorporator 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42504/serinc2