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SERINC3 (serine incorporator 3)

Identity

Alias (NCBI)AIGP1
DIFF33
SBBI99
TDE
TDE1
TMS-1
HGNC (Hugo) SERINC3
HGNC Alias symbDIFF33
TDE
SBBI99
TMS-1
AIGP1
HGNC Previous nameTDE1
HGNC Previous nametumor differentially expressed 1
LocusID (NCBI) 10955
Atlas_Id 42502
Location 20q13.12  [Link to chromosome band 20q13]
Location_base_pair Starts at 44496221 and ends at 44522116 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
F2R (5q13.3) / SERINC3 (20q13.12)PRG2 (11q12.1) / SERINC3 (20q13.12)SERINC3 (20q13.12) / LOC100507412 (-)
SERINC3 (20q13.12) / RND2 (17q21.31)SERINC3 (20q13.12) / SERINC3 (20q13.12)SERINC3 (20q13.12) / TWSG1 (18p11.22)
SERINC3 (20q13.12) / ZCCHC7 (9p13.2)SHISA5 (3p21.31) / SERINC3 (20q13.12)ZCCHC7 (9p13.2) / SERINC3 (20q13.12)
SERINC3 20q13.12 / TWSG1 18p11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(9;20)(p13;q13) SERINC3/ZCCHC7
t(9;20)(p13;q13) ZCCHC7/SERINC3


External links

 

Nomenclature
HGNC (Hugo)SERINC3   11699
Cards
Entrez_Gene (NCBI)SERINC3    serine incorporator 3
AliasesAIGP1; DIFF33; SBBI99; TDE; 
TDE1; TMS-1
GeneCards (Weizmann)SERINC3
Ensembl hg19 (Hinxton)ENSG00000132824 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132824 [Gene_View]  ENSG00000132824 [Sequence]  chr20:44496221-44522116 [Contig_View]  SERINC3 [Vega]
ICGC DataPortalENSG00000132824
TCGA cBioPortalSERINC3
AceView (NCBI)SERINC3
Genatlas (Paris)SERINC3
SOURCE (Princeton)SERINC3
Genetics Home Reference (NIH)SERINC3
Genomic and cartography
GoldenPath hg38 (UCSC)SERINC3  -     chr20:44496221-44522116 -  20q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SERINC3  -     20q13.12   [Description]    (hg19-Feb_2009)
GoldenPathSERINC3 - 20q13.12 [CytoView hg19]  SERINC3 - 20q13.12 [CytoView hg38]
ImmunoBaseENSG00000132824
Genome Data Viewer NCBISERINC3 [Mapview hg19]  
OMIM607165   
Gene and transcription
Genbank (Entrez)AA294859 AA772607 AF112227 AF153979 AK222923
RefSeq transcript (Entrez)NM_006811 NM_198941
Consensus coding sequences : CCDS (NCBI)SERINC3
Gene ExpressionSERINC3 [ NCBI-GEO ]   SERINC3 [ EBI - ARRAY_EXPRESS ]   SERINC3 [ SEEK ]   SERINC3 [ MEM ]
Gene Expression Viewer (FireBrowse)SERINC3 [ Firebrowse - Broad ]
GenevisibleExpression of SERINC3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10955
GTEX Portal (Tissue expression)SERINC3
Human Protein AtlasENSG00000132824-SERINC3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13530   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13530  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13530
PhosPhoSitePlusQ13530
Domains : Interpro (EBI)Serinc1/3    TDE1/TMS   
Domain families : Pfam (Sanger)Serinc (PF03348)   
Domain families : Pfam (NCBI)pfam03348   
Conserved Domain (NCBI)SERINC3
SuperfamilyQ13530
AlphaFold pdb e-kbQ13530   
Human Protein Atlas [tissue]ENSG00000132824-SERINC3 [tissue]
HPRD06201
Protein Interaction databases
DIP (DOE-UCLA)Q13530
IntAct (EBI)Q13530
BioGRIDSERINC3
STRING (EMBL)SERINC3
ZODIACSERINC3
Ontologies - Pathways
QuickGOQ13530
Ontology : AmiGOGolgi membrane  protein binding  plasma membrane  L-serine biosynthetic process  phosphatidylserine metabolic process  sphingolipid metabolic process  detection of virus  membrane  integral component of membrane  innate immune response  perinuclear region of cytoplasm  defense response to virus  positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIGolgi membrane  protein binding  plasma membrane  L-serine biosynthetic process  phosphatidylserine metabolic process  sphingolipid metabolic process  detection of virus  membrane  integral component of membrane  innate immune response  perinuclear region of cytoplasm  defense response to virus  positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
NDEx NetworkSERINC3
Atlas of Cancer Signalling NetworkSERINC3
Wikipedia pathwaysSERINC3
Orthology - Evolution
OrthoDB10955
GeneTree (enSembl)ENSG00000132824
Phylogenetic Trees/Animal Genes : TreeFamSERINC3
Homologs : HomoloGeneSERINC3
Homology/Alignments : Family Browser (UCSC)SERINC3
Gene fusions - Rearrangements
Fusion : MitelmanSERINC3/TWSG1 [20q13.12/18p11.22]  
Fusion : QuiverSERINC3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERINC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERINC3
dbVarSERINC3
ClinVarSERINC3
MonarchSERINC3
1000_GenomesSERINC3 
Exome Variant ServerSERINC3
GNOMAD BrowserENSG00000132824
Varsome BrowserSERINC3
ACMGSERINC3 variants
VarityQ13530
Genomic Variants (DGV)SERINC3 [DGVbeta]
DECIPHERSERINC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSERINC3 
Mutations
ICGC Data PortalSERINC3 
TCGA Data PortalSERINC3 
Broad Tumor PortalSERINC3
OASIS PortalSERINC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERINC3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSERINC3
Mutations and Diseases : HGMDSERINC3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSERINC3
DgiDB (Drug Gene Interaction Database)SERINC3
DoCM (Curated mutations)SERINC3
CIViC (Clinical Interpretations of Variants in Cancer)SERINC3
Cancer3DSERINC3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607165   
Orphanet
DisGeNETSERINC3
MedgenSERINC3
Genetic Testing Registry SERINC3
NextProtQ13530 [Medical]
GENETestsSERINC3
Target ValidationSERINC3
Huge Navigator SERINC3 [HugePedia]
ClinGenSERINC3
Clinical trials, drugs, therapy
MyCancerGenomeSERINC3
Protein Interactions : CTDSERINC3
Pharm GKB GenePA36418
PharosQ13530
Clinical trialSERINC3
Miscellaneous
canSAR (ICR)SERINC3
HarmonizomeSERINC3
DataMed IndexSERINC3
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSERINC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:30:38 CEST 2021

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