SERINC5 (serine incorporator 5)

2017-08-01  

Identity

HGNC
SERINC5
LOCATION
5q14.1
LOCUSID
256987
ALIAS
C5orf12,TPO1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 256987
MIM: 614551
HGNC: 18825
Ensembl: ENSG00000164300

Variants:

dbSNP: 256987
ClinVar: 256987
TCGA: ENSG00000164300
COSMIC: SERINC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164300ENST00000507668Q86VE9
ENSG00000164300ENST00000509193Q86VE9
ENSG00000164300ENST00000512972Q86VE9
ENSG00000164300ENST00000632581A0A0J9YYI4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614
Serine biosynthesisREACTOMER-HSA-977347

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
264167332015SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef.140
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
176729182007Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.17
311863272019Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5.6
239796072014Genome-wide analyses of borderline personality features.0
264167342015HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation.0
276811402016The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor.0
281794292017SERINC5 protein inhibits HIV-1 fusion pore formation by promoting functional inactivation of envelope glycoproteins.0
282751902017Identification of SERINC5-001 as the Predominant Spliced Isoform for HIV-1 Restriction.0
286593432017The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles.0

Citation

Dessen P

SERINC5 (serine incorporator 5)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57005/serinc5