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SERPINA5 (serpin family A member 5)

Identity

Alias_namesPLANH3
PCI
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Alias_symbol (synonym)PAI3
PROCI
Other aliasPAI-3
PCI-B
HGNC (Hugo) SERPINA5
LocusID (NCBI) 5104
Atlas_Id 43985
Location 14q32.13  [Link to chromosome band 14q32]
Location_base_pair Starts at 94581369 and ends at 94593120 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MACF1 (1p34.3) / SERPINA5 (14q32.13)PLCH1 (3q25.31) / SERPINA5 (14q32.13)SERPINA5 (14q32.13) / SERPINA5 (14q32.13)
ZNF678 (1q42.13) / SERPINA5 (14q32.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SERPINA5   8723
Cards
Entrez_Gene (NCBI)SERPINA5  5104  serpin family A member 5
AliasesPAI-3; PAI3; PCI; PCI-B; 
PLANH3; PROCI
GeneCards (Weizmann)SERPINA5
Ensembl hg19 (Hinxton)ENSG00000188488 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188488 [Gene_View]  ENSG00000188488 [Sequence]  chr14:94581369-94593120 [Contig_View]  SERPINA5 [Vega]
ICGC DataPortalENSG00000188488
TCGA cBioPortalSERPINA5
AceView (NCBI)SERPINA5
Genatlas (Paris)SERPINA5
WikiGenes5104
SOURCE (Princeton)SERPINA5
Genetics Home Reference (NIH)SERPINA5
Genomic and cartography
GoldenPath hg38 (UCSC)SERPINA5  -     chr14:94581369-94593120 +  14q32.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SERPINA5  -     14q32.13   [Description]    (hg19-Feb_2009)
EnsemblSERPINA5 - 14q32.13 [CytoView hg19]  SERPINA5 - 14q32.13 [CytoView hg38]
Mapping of homologs : NCBISERPINA5 [Mapview hg19]  SERPINA5 [Mapview hg38]
OMIM601841   
Gene and transcription
Genbank (Entrez)AI114432 AK096131 AK293192 AK298279 AK310869
RefSeq transcript (Entrez)NM_000624
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SERPINA5
Cluster EST : UnigeneHs.741309 [ NCBI ]
CGAP (NCI)Hs.741309
Alternative Splicing GalleryENSG00000188488
Gene ExpressionSERPINA5 [ NCBI-GEO ]   SERPINA5 [ EBI - ARRAY_EXPRESS ]   SERPINA5 [ SEEK ]   SERPINA5 [ MEM ]
Gene Expression Viewer (FireBrowse)SERPINA5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5104
GTEX Portal (Tissue expression)SERPINA5
Human Protein AtlasENSG00000188488-SERPINA5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05154   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05154  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05154
Splice isoforms : SwissVarP05154
PhosPhoSitePlusP05154
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Serpin_CS    Serpin_dom    Serpin_fam    Serpin_sf   
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
Conserved Domain (NCBI)SERPINA5
DMDM Disease mutations5104
Blocks (Seattle)SERPINA5
PDB (RSDB)1LQ8    1PAI    2HI9    2OL2    2PAI    3DY0   
PDB Europe1LQ8    1PAI    2HI9    2OL2    2PAI    3DY0   
PDB (PDBSum)1LQ8    1PAI    2HI9    2OL2    2PAI    3DY0   
PDB (IMB)1LQ8    1PAI    2HI9    2OL2    2PAI    3DY0   
Structural Biology KnowledgeBase1LQ8    1PAI    2HI9    2OL2    2PAI    3DY0   
SCOP (Structural Classification of Proteins)1LQ8    1PAI    2HI9    2OL2    2PAI    3DY0   
CATH (Classification of proteins structures)1LQ8    1PAI    2HI9    2OL2    2PAI    3DY0   
SuperfamilyP05154
Human Protein Atlas [tissue]ENSG00000188488-SERPINA5 [tissue]
Peptide AtlasP05154
HPRD03503
IPIIPI00007221   IPI01025109   IPI00917825   IPI01012831   IPI01025967   IPI01026339   IPI01026230   IPI01026440   IPI01024758   IPI01025405   IPI01025222   IPI01025579   
Protein Interaction databases
DIP (DOE-UCLA)P05154
IntAct (EBI)P05154
FunCoupENSG00000188488
BioGRIDSERPINA5
STRING (EMBL)SERPINA5
ZODIACSERPINA5
Ontologies - Pathways
QuickGOP05154
Ontology : AmiGOretinoic acid binding  protease binding  acrosomal membrane  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  glycosaminoglycan binding  extracellular region  extracellular region  extracellular space  extracellular space  lipid transport  spermatogenesis  fusion of sperm to egg plasma membrane involved in single fertilization  blood coagulation  heparin binding  external side of plasma membrane  negative regulation of endopeptidase activity  membrane  platelet alpha granule  platelet dense tubular network  phosphatidylcholine binding  acrosin binding  protein-containing complex  protein C inhibitor-TMPRSS7 complex  protein C inhibitor-TMPRSS11E complex  protein C inhibitor-PLAT complex  protein C inhibitor-PLAU complex  protein C inhibitor-thrombin complex  protein C inhibitor-KLK3 complex  protein C inhibitor-plasma kallikrein complex  negative regulation of hydrolase activity  seminal vesicle development  collagen-containing extracellular matrix  extracellular exosome  extracellular exosome  protein C inhibitor-coagulation factor V complex  protein C inhibitor-coagulation factor Xa complex  protein C inhibitor-coagulation factor XI complex  
Ontology : EGO-EBIretinoic acid binding  protease binding  acrosomal membrane  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  glycosaminoglycan binding  extracellular region  extracellular region  extracellular space  extracellular space  lipid transport  spermatogenesis  fusion of sperm to egg plasma membrane involved in single fertilization  blood coagulation  heparin binding  external side of plasma membrane  negative regulation of endopeptidase activity  membrane  platelet alpha granule  platelet dense tubular network  phosphatidylcholine binding  acrosin binding  protein-containing complex  protein C inhibitor-TMPRSS7 complex  protein C inhibitor-TMPRSS11E complex  protein C inhibitor-PLAT complex  protein C inhibitor-PLAU complex  protein C inhibitor-thrombin complex  protein C inhibitor-KLK3 complex  protein C inhibitor-plasma kallikrein complex  negative regulation of hydrolase activity  seminal vesicle development  collagen-containing extracellular matrix  extracellular exosome  extracellular exosome  protein C inhibitor-coagulation factor V complex  protein C inhibitor-coagulation factor Xa complex  protein C inhibitor-coagulation factor XI complex  
Pathways : KEGGComplement and coagulation cascades   
NDEx NetworkSERPINA5
Atlas of Cancer Signalling NetworkSERPINA5
Wikipedia pathwaysSERPINA5
Orthology - Evolution
OrthoDB5104
GeneTree (enSembl)ENSG00000188488
Phylogenetic Trees/Animal Genes : TreeFamSERPINA5
HOGENOMP05154
Homologs : HomoloGeneSERPINA5
Homology/Alignments : Family Browser (UCSC)SERPINA5
Gene fusions - Rearrangements
Fusion : QuiverSERPINA5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERPINA5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERPINA5
dbVarSERPINA5
ClinVarSERPINA5
1000_GenomesSERPINA5 
Exome Variant ServerSERPINA5
ExAC (Exome Aggregation Consortium)ENSG00000188488
GNOMAD BrowserENSG00000188488
Varsome BrowserSERPINA5
Genetic variants : HAPMAP5104
Genomic Variants (DGV)SERPINA5 [DGVbeta]
DECIPHERSERPINA5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSERPINA5 
Mutations
ICGC Data PortalSERPINA5 
TCGA Data PortalSERPINA5 
Broad Tumor PortalSERPINA5
OASIS PortalSERPINA5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERPINA5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSERPINA5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SERPINA5
DgiDB (Drug Gene Interaction Database)SERPINA5
DoCM (Curated mutations)SERPINA5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SERPINA5 (select a term)
intoGenSERPINA5
Cancer3DSERPINA5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601841   
Orphanet
DisGeNETSERPINA5
MedgenSERPINA5
Genetic Testing Registry SERPINA5
NextProtP05154 [Medical]
TSGene5104
GENETestsSERPINA5
Target ValidationSERPINA5
Huge Navigator SERPINA5 [HugePedia]
snp3D : Map Gene to Disease5104
BioCentury BCIQSERPINA5
ClinGenSERPINA5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5104
Chemical/Pharm GKB GenePA35505
Clinical trialSERPINA5
Miscellaneous
canSAR (ICR)SERPINA5 (select the gene name)
DataMed IndexSERPINA5
Probes
Litterature
PubMed101 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSERPINA5
EVEXSERPINA5
GoPubMedSERPINA5
iHOPSERPINA5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:37:24 CET 2019

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