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SERPINB12 (serpin family B member 12)

Identity

Alias_namesserine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12
serpin peptidase inhibitor, clade B (ovalbumin), member 12
Alias_symbol (synonym)YUKOPIN
Other alias
HGNC (Hugo) SERPINB12
LocusID (NCBI) 89777
Atlas_Id 73145
Location 18q21.33  [Link to chromosome band 18q21]
Location_base_pair Starts at 63556160 and ends at 63569327 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SERPINB12   14220
Cards
Entrez_Gene (NCBI)SERPINB12  89777  serpin family B member 12
AliasesYUKOPIN
GeneCards (Weizmann)SERPINB12
Ensembl hg19 (Hinxton)ENSG00000166634 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166634 [Gene_View]  chr18:63556160-63569327 [Contig_View]  SERPINB12 [Vega]
ICGC DataPortalENSG00000166634
TCGA cBioPortalSERPINB12
AceView (NCBI)SERPINB12
Genatlas (Paris)SERPINB12
WikiGenes89777
SOURCE (Princeton)SERPINB12
Genetics Home Reference (NIH)SERPINB12
Genomic and cartography
GoldenPath hg38 (UCSC)SERPINB12  -     chr18:63556160-63569327 +  18q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SERPINB12  -     18q21.33   [Description]    (hg19-Feb_2009)
EnsemblSERPINB12 - 18q21.33 [CytoView hg19]  SERPINB12 - 18q21.33 [CytoView hg38]
Mapping of homologs : NCBISERPINB12 [Mapview hg19]  SERPINB12 [Mapview hg38]
OMIM615662   
Gene and transcription
Genbank (Entrez)AF411191 AK309754 BC103884 BC103885
RefSeq transcript (Entrez)NM_001307928 NM_080474
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SERPINB12
Cluster EST : UnigeneHs.348541 [ NCBI ]
CGAP (NCI)Hs.348541
Alternative Splicing GalleryENSG00000166634
Gene ExpressionSERPINB12 [ NCBI-GEO ]   SERPINB12 [ EBI - ARRAY_EXPRESS ]   SERPINB12 [ SEEK ]   SERPINB12 [ MEM ]
Gene Expression Viewer (FireBrowse)SERPINB12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)89777
GTEX Portal (Tissue expression)SERPINB12
Human Protein AtlasENSG00000166634-SERPINB12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96P63   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96P63  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96P63
Splice isoforms : SwissVarQ96P63
PhosPhoSitePlusQ96P63
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Serpin_CS    Serpin_dom    Serpin_fam   
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
Conserved Domain (NCBI)SERPINB12
DMDM Disease mutations89777
Blocks (Seattle)SERPINB12
SuperfamilyQ96P63
Human Protein Atlas [tissue]ENSG00000166634-SERPINB12 [tissue]
Peptide AtlasQ96P63
HPRD11548
IPIIPI00033583   IPI00643202   
Protein Interaction databases
DIP (DOE-UCLA)Q96P63
IntAct (EBI)Q96P63
FunCoupENSG00000166634
BioGRIDSERPINB12
STRING (EMBL)SERPINB12
ZODIACSERPINB12
Ontologies - Pathways
QuickGOQ96P63
Ontology : AmiGOhematopoietic progenitor cell differentiation  serine-type endopeptidase inhibitor activity  extracellular space  cytoplasm  plasma membrane  negative regulation of endopeptidase activity  enzyme binding  negative regulation of protein catabolic process  neutrophil degranulation  extracellular exosome  ficolin-1-rich granule membrane  
Ontology : EGO-EBIhematopoietic progenitor cell differentiation  serine-type endopeptidase inhibitor activity  extracellular space  cytoplasm  plasma membrane  negative regulation of endopeptidase activity  enzyme binding  negative regulation of protein catabolic process  neutrophil degranulation  extracellular exosome  ficolin-1-rich granule membrane  
NDEx NetworkSERPINB12
Atlas of Cancer Signalling NetworkSERPINB12
Wikipedia pathwaysSERPINB12
Orthology - Evolution
OrthoDB89777
GeneTree (enSembl)ENSG00000166634
Phylogenetic Trees/Animal Genes : TreeFamSERPINB12
HOVERGENQ96P63
HOGENOMQ96P63
Homologs : HomoloGeneSERPINB12
Homology/Alignments : Family Browser (UCSC)SERPINB12
Gene fusions - Rearrangements
Fusion: Tumor Portal SERPINB12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERPINB12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERPINB12
dbVarSERPINB12
ClinVarSERPINB12
1000_GenomesSERPINB12 
Exome Variant ServerSERPINB12
ExAC (Exome Aggregation Consortium)ENSG00000166634
GNOMAD BrowserENSG00000166634
Genetic variants : HAPMAP89777
Genomic Variants (DGV)SERPINB12 [DGVbeta]
DECIPHERSERPINB12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSERPINB12 
Mutations
ICGC Data PortalSERPINB12 
TCGA Data PortalSERPINB12 
Broad Tumor PortalSERPINB12
OASIS PortalSERPINB12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERPINB12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSERPINB12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SERPINB12
DgiDB (Drug Gene Interaction Database)SERPINB12
DoCM (Curated mutations)SERPINB12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SERPINB12 (select a term)
intoGenSERPINB12
Cancer3DSERPINB12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615662   
Orphanet
MedgenSERPINB12
Genetic Testing Registry SERPINB12
NextProtQ96P63 [Medical]
TSGene89777
GENETestsSERPINB12
Target ValidationSERPINB12
Huge Navigator SERPINB12 [HugePedia]
snp3D : Map Gene to Disease89777
BioCentury BCIQSERPINB12
ClinGenSERPINB12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD89777
Chemical/Pharm GKB GenePA37859
Clinical trialSERPINB12
Miscellaneous
canSAR (ICR)SERPINB12 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSERPINB12
EVEXSERPINB12
GoPubMedSERPINB12
iHOPSERPINB12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:26:51 CET 2017

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