SERPINB2 (serpin family B member 2)

2003-08-01  

Identity

HGNC
SERPINB2
LOCATION
18q21.33
LOCUSID
5055
ALIAS
HsT1201,PAI,PAI-2,PAI2,PLANH2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5055
MIM: 173390
HGNC: 8584
Ensembl: ENSG00000197632

Variants:

dbSNP: 5055
ClinVar: 5055
TCGA: ENSG00000197632
COSMIC: SERPINB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197632ENST00000299502P05120
ENSG00000197632ENST00000404622E9PDK7
ENSG00000197632ENST00000413956E7EPJ9
ENSG00000197632ENST00000443281E7ERB5
ENSG00000197632ENST00000457692P05120

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
HemostasisREACTOMER-HSA-109582
Dissolution of Fibrin ClotREACTOMER-HSA-75205

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
186326172008SerpinB2 protection of retinoblastoma protein from calpain enhances tumor cell survival.32
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
172678402007Genetic polymorphisms and spontaneous preterm birth.21
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19
189779902008Candidate genes and cerebral palsy: a population-based study.18
283464212017SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer.18
129444782003Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif.16
192384442009The genomic basis of cerebral palsy: a HuGE systematic literature review.16
119297702002Plasminogen activator inhibitor type 2: a regulator of monocyte proliferation and differentiation.14

Citation

Dessen P

SERPINB2 (serpin family B member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42264/serpinb2