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SERPINB2 (serpin family B member 2)

Identity

Alias_namesPLANH2
PAI2
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
serpin peptidase inhibitor, clade B (ovalbumin), member 2
Alias_symbol (synonym)HsT1201
Other aliasPAI
PAI-2
HGNC (Hugo) SERPINB2
LocusID (NCBI) 5055
Atlas_Id 42264
Location 18q21.33  [Link to chromosome band 18q21]
Location_base_pair Starts at 61554939 and ends at 61571124 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TBCB (19q13.12) / SERPINB2 (18q21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SERPINB2   8584
Cards
Entrez_Gene (NCBI)SERPINB2  5055  serpin family B member 2
AliasesHsT1201; PAI; PAI-2; PAI2; 
PLANH2
GeneCards (Weizmann)SERPINB2
Ensembl hg19 (Hinxton)ENSG00000197632 [Gene_View]  chr18:61554939-61571124 [Contig_View]  SERPINB2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000197632 [Gene_View]  chr18:61554939-61571124 [Contig_View]  SERPINB2 [Vega]
ICGC DataPortalENSG00000197632
TCGA cBioPortalSERPINB2
AceView (NCBI)SERPINB2
Genatlas (Paris)SERPINB2
WikiGenes5055
SOURCE (Princeton)SERPINB2
Genetics Home Reference (NIH)SERPINB2
Genomic and cartography
GoldenPath hg19 (UCSC)SERPINB2  -     chr18:61554939-61571124 +  18q21.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SERPINB2  -     18q21.33   [Description]    (hg38-Dec_2013)
EnsemblSERPINB2 - 18q21.33 [CytoView hg19]  SERPINB2 - 18q21.33 [CytoView hg38]
Mapping of homologs : NCBISERPINB2 [Mapview hg19]  SERPINB2 [Mapview hg38]
OMIM173390   
Gene and transcription
Genbank (Entrez)A21238 A21254 A32415 AK313159 BC012609
RefSeq transcript (Entrez)NM_001143818 NM_002575
RefSeq genomic (Entrez)NC_000018 NC_018929 NT_010966 NW_004929411
Consensus coding sequences : CCDS (NCBI)SERPINB2
Cluster EST : UnigeneHs.594481 [ NCBI ]
CGAP (NCI)Hs.594481
Alternative Splicing GalleryENSG00000197632
Gene ExpressionSERPINB2 [ NCBI-GEO ]   SERPINB2 [ EBI - ARRAY_EXPRESS ]   SERPINB2 [ SEEK ]   SERPINB2 [ MEM ]
Gene Expression Viewer (FireBrowse)SERPINB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5055
GTEX Portal (Tissue expression)SERPINB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05120   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05120  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05120
Splice isoforms : SwissVarP05120
PhosPhoSitePlusP05120
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)PAI-2    Serpin_CS    Serpin_dom    Serpin_fam   
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
Conserved Domain (NCBI)SERPINB2
DMDM Disease mutations5055
Blocks (Seattle)SERPINB2
PDB (SRS)1BY7    1JRR    2ARQ    2ARR   
PDB (PDBSum)1BY7    1JRR    2ARQ    2ARR   
PDB (IMB)1BY7    1JRR    2ARQ    2ARR   
PDB (RSDB)1BY7    1JRR    2ARQ    2ARR   
Structural Biology KnowledgeBase1BY7    1JRR    2ARQ    2ARR   
SCOP (Structural Classification of Proteins)1BY7    1JRR    2ARQ    2ARR   
CATH (Classification of proteins structures)1BY7    1JRR    2ARQ    2ARR   
SuperfamilyP05120
Human Protein AtlasENSG00000197632
Peptide AtlasP05120
HPRD01420
IPIIPI00007117   IPI00797177   IPI00797920   IPI00789721   
Protein Interaction databases
DIP (DOE-UCLA)P05120
IntAct (EBI)P05120
FunCoupENSG00000197632
BioGRIDSERPINB2
STRING (EMBL)SERPINB2
ZODIACSERPINB2
Ontologies - Pathways
QuickGOP05120
Ontology : AmiGOserine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  extracellular region  extracellular space  cytoplasm  plasma membrane  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  wound healing  fibrinolysis  negative regulation of apoptotic process  
Ontology : EGO-EBIserine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  extracellular region  extracellular space  cytoplasm  plasma membrane  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  wound healing  fibrinolysis  negative regulation of apoptotic process  
Pathways : BIOCARTAFibrinolysis Pathway [Genes]   
Pathways : KEGGAmoebiasis   
NDEx NetworkSERPINB2
Atlas of Cancer Signalling NetworkSERPINB2
Wikipedia pathwaysSERPINB2
Orthology - Evolution
OrthoDB5055
GeneTree (enSembl)ENSG00000197632
Phylogenetic Trees/Animal Genes : TreeFamSERPINB2
HOVERGENP05120
HOGENOMP05120
Homologs : HomoloGeneSERPINB2
Homology/Alignments : Family Browser (UCSC)SERPINB2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERPINB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERPINB2
dbVarSERPINB2
ClinVarSERPINB2
1000_GenomesSERPINB2 
Exome Variant ServerSERPINB2
ExAC (Exome Aggregation Consortium)SERPINB2 (select the gene name)
Genetic variants : HAPMAP5055
Genomic Variants (DGV)SERPINB2 [DGVbeta]
DECIPHER (Syndromes)18:61554939-61571124  ENSG00000197632
CONAN: Copy Number AnalysisSERPINB2 
Mutations
ICGC Data PortalSERPINB2 
TCGA Data PortalSERPINB2 
Broad Tumor PortalSERPINB2
OASIS PortalSERPINB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERPINB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSERPINB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SERPINB2
DgiDB (Drug Gene Interaction Database)SERPINB2
DoCM (Curated mutations)SERPINB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SERPINB2 (select a term)
intoGenSERPINB2
Cancer3DSERPINB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM173390   
Orphanet
MedgenSERPINB2
Genetic Testing Registry SERPINB2
NextProtP05120 [Medical]
TSGene5055
GENETestsSERPINB2
Huge Navigator SERPINB2 [HugePedia]
snp3D : Map Gene to Disease5055
BioCentury BCIQSERPINB2
ClinGenSERPINB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5055
Chemical/Pharm GKB GenePA35500
Clinical trialSERPINB2
Miscellaneous
canSAR (ICR)SERPINB2 (select the gene name)
Probes
Litterature
PubMed100 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSERPINB2
EVEXSERPINB2
GoPubMedSERPINB2
iHOPSERPINB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:18:53 CEST 2017

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