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SERPINB4 (serpin family B member 4)

Identity

Alias_namesSCCA2
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
Alias_symbol (synonym)PI11
LEUPIN
SCCA-2
SCCA1
Other alias
HGNC (Hugo) SERPINB4
LocusID (NCBI) 6318
Atlas_Id 42266
Location 18q21.33  [Link to chromosome band 18q21]
Location_base_pair Starts at 63637259 and ends at 63644319 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SERPINB4 (18q21.33) / WIPI1 (17q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Penile tumors: an overview


External links

Nomenclature
HGNC (Hugo)SERPINB4   10570
Cards
Entrez_Gene (NCBI)SERPINB4  6318  serpin family B member 4
AliasesLEUPIN; PI11; SCCA-2; SCCA1; 
SCCA2
GeneCards (Weizmann)SERPINB4
Ensembl hg19 (Hinxton)ENSG00000206073 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000206073 [Gene_View]  chr18:63637259-63644319 [Contig_View]  SERPINB4 [Vega]
ICGC DataPortalENSG00000206073
TCGA cBioPortalSERPINB4
AceView (NCBI)SERPINB4
Genatlas (Paris)SERPINB4
WikiGenes6318
SOURCE (Princeton)SERPINB4
Genetics Home Reference (NIH)SERPINB4
Genomic and cartography
GoldenPath hg38 (UCSC)SERPINB4  -     chr18:63637259-63644319 -  18q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SERPINB4  -     18q21.33   [Description]    (hg19-Feb_2009)
EnsemblSERPINB4 - 18q21.33 [CytoView hg19]  SERPINB4 - 18q21.33 [CytoView hg38]
Mapping of homologs : NCBISERPINB4 [Mapview hg19]  SERPINB4 [Mapview hg38]
OMIM600518   
Gene and transcription
Genbank (Entrez)AB046400 AF461147 AK292212 AY245780 AY245782
RefSeq transcript (Entrez)NM_002974 NM_175041
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SERPINB4
Cluster EST : UnigeneHs.123035 [ NCBI ]
CGAP (NCI)Hs.123035
Alternative Splicing GalleryENSG00000206073
Gene ExpressionSERPINB4 [ NCBI-GEO ]   SERPINB4 [ EBI - ARRAY_EXPRESS ]   SERPINB4 [ SEEK ]   SERPINB4 [ MEM ]
Gene Expression Viewer (FireBrowse)SERPINB4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6318
GTEX Portal (Tissue expression)SERPINB4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48594   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48594  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48594
Splice isoforms : SwissVarP48594
PhosPhoSitePlusP48594
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Serpin_CS    Serpin_dom    Serpin_fam   
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
Conserved Domain (NCBI)SERPINB4
DMDM Disease mutations6318
Blocks (Seattle)SERPINB4
SuperfamilyP48594
Human Protein AtlasENSG00000206073
Peptide AtlasP48594
HPRD02746
IPIIPI00010303   IPI00796607   IPI00412407   IPI00657650   
Protein Interaction databases
DIP (DOE-UCLA)P48594
IntAct (EBI)P48594
FunCoupENSG00000206073
BioGRIDSERPINB4
STRING (EMBL)SERPINB4
ZODIACSERPINB4
Ontologies - Pathways
QuickGOP48594
Ontology : AmiGOprotease binding  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  extracellular space  intracellular  cytoplasm  negative regulation of peptidase activity  negative regulation of endopeptidase activity  enzyme binding  regulation of proteolysis  protection from natural killer cell mediated cytotoxicity  extracellular exosome  
Ontology : EGO-EBIprotease binding  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  extracellular space  intracellular  cytoplasm  negative regulation of peptidase activity  negative regulation of endopeptidase activity  enzyme binding  regulation of proteolysis  protection from natural killer cell mediated cytotoxicity  extracellular exosome  
Pathways : KEGGAmoebiasis   
NDEx NetworkSERPINB4
Atlas of Cancer Signalling NetworkSERPINB4
Wikipedia pathwaysSERPINB4
Orthology - Evolution
OrthoDB6318
GeneTree (enSembl)ENSG00000206073
Phylogenetic Trees/Animal Genes : TreeFamSERPINB4
HOVERGENP48594
HOGENOMP48594
Homologs : HomoloGeneSERPINB4
Homology/Alignments : Family Browser (UCSC)SERPINB4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERPINB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERPINB4
dbVarSERPINB4
ClinVarSERPINB4
1000_GenomesSERPINB4 
Exome Variant ServerSERPINB4
ExAC (Exome Aggregation Consortium)SERPINB4 (select the gene name)
Genetic variants : HAPMAP6318
Genomic Variants (DGV)SERPINB4 [DGVbeta]
DECIPHERSERPINB4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSERPINB4 
Mutations
ICGC Data PortalSERPINB4 
TCGA Data PortalSERPINB4 
Broad Tumor PortalSERPINB4
OASIS PortalSERPINB4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERPINB4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSERPINB4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SERPINB4
DgiDB (Drug Gene Interaction Database)SERPINB4
DoCM (Curated mutations)SERPINB4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SERPINB4 (select a term)
intoGenSERPINB4
Cancer3DSERPINB4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600518   
Orphanet
MedgenSERPINB4
Genetic Testing Registry SERPINB4
NextProtP48594 [Medical]
TSGene6318
GENETestsSERPINB4
Target ValidationSERPINB4
Huge Navigator SERPINB4 [HugePedia]
snp3D : Map Gene to Disease6318
BioCentury BCIQSERPINB4
ClinGenSERPINB4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6318
Chemical/Pharm GKB GenePA35539
Clinical trialSERPINB4
Miscellaneous
canSAR (ICR)SERPINB4 (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSERPINB4
EVEXSERPINB4
GoPubMedSERPINB4
iHOPSERPINB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:30:35 CEST 2017

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