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SERPINB7 (serpin family B member 7)

Identity

Alias_namesserine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
Alias_symbol (synonym)MEGSIN
Other aliasPPKN
TP55
HGNC (Hugo) SERPINB7
LocusID (NCBI) 8710
Atlas_Id 53692
Location 18q21.33  [Link to chromosome band 18q21]
Location_base_pair Starts at 61420281 and ends at 61472610 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SERPINB7   13902
Cards
Entrez_Gene (NCBI)SERPINB7  8710  serpin family B member 7
AliasesMEGSIN; PPKN; TP55
GeneCards (Weizmann)SERPINB7
Ensembl hg19 (Hinxton)ENSG00000166396 [Gene_View]  chr18:61420281-61472610 [Contig_View]  SERPINB7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000166396 [Gene_View]  chr18:61420281-61472610 [Contig_View]  SERPINB7 [Vega]
ICGC DataPortalENSG00000166396
TCGA cBioPortalSERPINB7
AceView (NCBI)SERPINB7
Genatlas (Paris)SERPINB7
WikiGenes8710
SOURCE (Princeton)SERPINB7
Genetics Home Reference (NIH)SERPINB7
Genomic and cartography
GoldenPath hg19 (UCSC)SERPINB7  -     chr18:61420281-61472610 +  18q21.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SERPINB7  -     18q21.33   [Description]    (hg38-Dec_2013)
EnsemblSERPINB7 - 18q21.33 [CytoView hg19]  SERPINB7 - 18q21.33 [CytoView hg38]
Mapping of homologs : NCBISERPINB7 [Mapview hg19]  SERPINB7 [Mapview hg38]
OMIM603357   615598   
Gene and transcription
Genbank (Entrez)AF027866 AK290673 AK290876 AK300828 BC069417
RefSeq transcript (Entrez)NM_001040147 NM_001261830 NM_001261831 NM_003784
RefSeq genomic (Entrez)NC_000018 NC_018929 NG_034150 NT_010966 NW_004929411
Consensus coding sequences : CCDS (NCBI)SERPINB7
Cluster EST : UnigeneHs.742388 [ NCBI ]
CGAP (NCI)Hs.742388
Alternative Splicing GalleryENSG00000166396
Gene ExpressionSERPINB7 [ NCBI-GEO ]   SERPINB7 [ EBI - ARRAY_EXPRESS ]   SERPINB7 [ SEEK ]   SERPINB7 [ MEM ]
Gene Expression Viewer (FireBrowse)SERPINB7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8710
GTEX Portal (Tissue expression)SERPINB7
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75635   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75635  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75635
Splice isoforms : SwissVarO75635
PhosPhoSitePlusO75635
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Serpin_CS    Serpin_dom    Serpin_fam   
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
Conserved Domain (NCBI)SERPINB7
DMDM Disease mutations8710
Blocks (Seattle)SERPINB7
SuperfamilyO75635
Human Protein AtlasENSG00000166396
Peptide AtlasO75635
HPRD04524
IPIIPI00021555   IPI01010407   IPI00657987   IPI00796179   
Protein Interaction databases
DIP (DOE-UCLA)O75635
IntAct (EBI)O75635
FunCoupENSG00000166396
BioGRIDSERPINB7
STRING (EMBL)SERPINB7
ZODIACSERPINB7
Ontologies - Pathways
QuickGOO75635
Ontology : AmiGOserine-type endopeptidase inhibitor activity  extracellular space  cytoplasm  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  positive regulation of transforming growth factor beta1 production  positive regulation of collagen biosynthetic process  positive regulation of glomerular mesangial cell proliferation  positive regulation of platelet-derived growth factor production  
Ontology : EGO-EBIserine-type endopeptidase inhibitor activity  extracellular space  cytoplasm  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  positive regulation of transforming growth factor beta1 production  positive regulation of collagen biosynthetic process  positive regulation of glomerular mesangial cell proliferation  positive regulation of platelet-derived growth factor production  
NDEx NetworkSERPINB7
Atlas of Cancer Signalling NetworkSERPINB7
Wikipedia pathwaysSERPINB7
Orthology - Evolution
OrthoDB8710
GeneTree (enSembl)ENSG00000166396
Phylogenetic Trees/Animal Genes : TreeFamSERPINB7
HOVERGENO75635
HOGENOMO75635
Homologs : HomoloGeneSERPINB7
Homology/Alignments : Family Browser (UCSC)SERPINB7
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERPINB7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERPINB7
dbVarSERPINB7
ClinVarSERPINB7
1000_GenomesSERPINB7 
Exome Variant ServerSERPINB7
ExAC (Exome Aggregation Consortium)SERPINB7 (select the gene name)
Genetic variants : HAPMAP8710
Genomic Variants (DGV)SERPINB7 [DGVbeta]
DECIPHER (Syndromes)18:61420281-61472610  ENSG00000166396
CONAN: Copy Number AnalysisSERPINB7 
Mutations
ICGC Data PortalSERPINB7 
TCGA Data PortalSERPINB7 
Broad Tumor PortalSERPINB7
OASIS PortalSERPINB7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERPINB7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSERPINB7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SERPINB7
DgiDB (Drug Gene Interaction Database)SERPINB7
DoCM (Curated mutations)SERPINB7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SERPINB7 (select a term)
intoGenSERPINB7
Cancer3DSERPINB7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603357    615598   
Orphanet17011   
MedgenSERPINB7
Genetic Testing Registry SERPINB7
NextProtO75635 [Medical]
TSGene8710
GENETestsSERPINB7
Huge Navigator SERPINB7 [HugePedia]
snp3D : Map Gene to Disease8710
BioCentury BCIQSERPINB7
ClinGenSERPINB7 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8710
Chemical/Pharm GKB GenePA37825
Clinical trialSERPINB7
Miscellaneous
canSAR (ICR)SERPINB7 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSERPINB7
EVEXSERPINB7
GoPubMedSERPINB7
iHOPSERPINB7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:26:49 CET 2017

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