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SERPINB9 (serpin family B member 9)

Identity

Alias_namesPI9
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9
serpin peptidase inhibitor, clade B (ovalbumin), member 9
Alias_symbol (synonym)CAP3
Other aliasCAP-3
PI-9
HGNC (Hugo) SERPINB9
LocusID (NCBI) 5272
Atlas_Id 46229
Location 6p25.2  [Link to chromosome band 6p25]
Location_base_pair Starts at 2887266 and ends at 2903312 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RIPK1 (6p25.2) / SERPINB9 (6p25.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  RIPK1/SERPINB9 (6p25)


External links

Nomenclature
HGNC (Hugo)SERPINB9   8955
Cards
Entrez_Gene (NCBI)SERPINB9  5272  serpin family B member 9
AliasesCAP-3; CAP3; PI-9; PI9
GeneCards (Weizmann)SERPINB9
Ensembl hg19 (Hinxton)ENSG00000170542 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170542 [Gene_View]  ENSG00000170542 [Sequence]  chr6:2887266-2903312 [Contig_View]  SERPINB9 [Vega]
ICGC DataPortalENSG00000170542
TCGA cBioPortalSERPINB9
AceView (NCBI)SERPINB9
Genatlas (Paris)SERPINB9
WikiGenes5272
SOURCE (Princeton)SERPINB9
Genetics Home Reference (NIH)SERPINB9
Genomic and cartography
GoldenPath hg38 (UCSC)SERPINB9  -     chr6:2887266-2903312 -  6p25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SERPINB9  -     6p25.2   [Description]    (hg19-Feb_2009)
EnsemblSERPINB9 - 6p25.2 [CytoView hg19]  SERPINB9 - 6p25.2 [CytoView hg38]
Mapping of homologs : NCBISERPINB9 [Mapview hg19]  SERPINB9 [Mapview hg38]
OMIM601799   
Gene and transcription
Genbank (Entrez)AB060690 AK314842 BC002538 BT006673 BX485378
RefSeq transcript (Entrez)NM_004155
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SERPINB9
Cluster EST : UnigeneHs.104879 [ NCBI ]
CGAP (NCI)Hs.104879
Alternative Splicing GalleryENSG00000170542
Gene ExpressionSERPINB9 [ NCBI-GEO ]   SERPINB9 [ EBI - ARRAY_EXPRESS ]   SERPINB9 [ SEEK ]   SERPINB9 [ MEM ]
Gene Expression Viewer (FireBrowse)SERPINB9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5272
GTEX Portal (Tissue expression)SERPINB9
Human Protein AtlasENSG00000170542-SERPINB9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50453   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50453  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50453
Splice isoforms : SwissVarP50453
PhosPhoSitePlusP50453
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Serpin_B9/Maspin    Serpin_CS    Serpin_dom    Serpin_fam    Serpin_sf   
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
Conserved Domain (NCBI)SERPINB9
DMDM Disease mutations5272
Blocks (Seattle)SERPINB9
SuperfamilyP50453
Human Protein Atlas [tissue]ENSG00000170542-SERPINB9 [tissue]
Peptide AtlasP50453
HPRD03480
IPIIPI00032139   
Protein Interaction databases
DIP (DOE-UCLA)P50453
IntAct (EBI)P50453
FunCoupENSG00000170542
BioGRIDSERPINB9
STRING (EMBL)SERPINB9
ZODIACSERPINB9
Ontologies - Pathways
QuickGOP50453
Ontology : AmiGOprotease binding  mast cell mediated immunity  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular space  extracellular space  intracellular  nucleus  nucleoplasm  cytoplasm  cytoplasm  Golgi apparatus  cytosol  apoptotic process  immune response  response to bacterium  positive regulation of gene expression  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  membrane  negative regulation by symbiont of host apoptotic process  protection from natural killer cell mediated cytotoxicity  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  collagen-containing extracellular matrix  extracellular exosome  cellular response to estrogen stimulus  
Ontology : EGO-EBIprotease binding  mast cell mediated immunity  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular space  extracellular space  intracellular  nucleus  nucleoplasm  cytoplasm  cytoplasm  Golgi apparatus  cytosol  apoptotic process  immune response  response to bacterium  positive regulation of gene expression  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  membrane  negative regulation by symbiont of host apoptotic process  protection from natural killer cell mediated cytotoxicity  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  collagen-containing extracellular matrix  extracellular exosome  cellular response to estrogen stimulus  
Pathways : KEGGAmoebiasis   
NDEx NetworkSERPINB9
Atlas of Cancer Signalling NetworkSERPINB9
Wikipedia pathwaysSERPINB9
Orthology - Evolution
OrthoDB5272
GeneTree (enSembl)ENSG00000170542
Phylogenetic Trees/Animal Genes : TreeFamSERPINB9
HOVERGENP50453
HOGENOMP50453
Homologs : HomoloGeneSERPINB9
Homology/Alignments : Family Browser (UCSC)SERPINB9
Gene fusions - Rearrangements
Fusion : MitelmanRIPK1/SERPINB9 [6p25.2/6p25.2]  [t(6;6)(p25;p25)]  
Fusion : QuiverSERPINB9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERPINB9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERPINB9
dbVarSERPINB9
ClinVarSERPINB9
1000_GenomesSERPINB9 
Exome Variant ServerSERPINB9
ExAC (Exome Aggregation Consortium)ENSG00000170542
GNOMAD BrowserENSG00000170542
Varsome BrowserSERPINB9
Genetic variants : HAPMAP5272
Genomic Variants (DGV)SERPINB9 [DGVbeta]
DECIPHERSERPINB9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSERPINB9 
Mutations
ICGC Data PortalSERPINB9 
TCGA Data PortalSERPINB9 
Broad Tumor PortalSERPINB9
OASIS PortalSERPINB9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERPINB9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSERPINB9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SERPINB9
DgiDB (Drug Gene Interaction Database)SERPINB9
DoCM (Curated mutations)SERPINB9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SERPINB9 (select a term)
intoGenSERPINB9
Cancer3DSERPINB9(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601799   
Orphanet
DisGeNETSERPINB9
MedgenSERPINB9
Genetic Testing Registry SERPINB9
NextProtP50453 [Medical]
TSGene5272
GENETestsSERPINB9
Target ValidationSERPINB9
Huge Navigator SERPINB9 [HugePedia]
snp3D : Map Gene to Disease5272
BioCentury BCIQSERPINB9
ClinGenSERPINB9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5272
Chemical/Pharm GKB GenePA35519
Clinical trialSERPINB9
Miscellaneous
canSAR (ICR)SERPINB9 (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSERPINB9
EVEXSERPINB9
GoPubMedSERPINB9
iHOPSERPINB9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:38:22 CET 2018

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