Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SERPINE2 (serpin family E member 2)

Identity

Alias_namesPI7
serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Alias_symbol (synonym)PN1
GDN
PNI
nexin
Other aliasGDNPF
PI-7
PN-1
HGNC (Hugo) SERPINE2
LocusID (NCBI) 5270
Atlas_Id 49888
Location 2q36.1  [Link to chromosome band 2q36]
Location_base_pair Starts at 224839765 and ends at 224904036 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FAM3C (7q31.31) / SERPINE2 (2q36.1)IL13RA1 (Xq24) / SERPINE2 (2q36.1)MAML3 (4q31.1) / SERPINE2 (2q36.1)
SERPINE2 (2q36.1) / RABEP1 (17p13.2)SERPINE2 (2q36.1) / XRCC5 (2q35)SERPINE2 2q36.1 / RABEP1 17p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SERPINE2   8951
Cards
Entrez_Gene (NCBI)SERPINE2  5270  serpin family E member 2
AliasesGDN; GDNPF; PI-7; PI7; 
PN-1; PN1; PNI
GeneCards (Weizmann)SERPINE2
Ensembl hg19 (Hinxton)ENSG00000135919 [Gene_View]  chr2:224839765-224904036 [Contig_View]  SERPINE2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000135919 [Gene_View]  chr2:224839765-224904036 [Contig_View]  SERPINE2 [Vega]
ICGC DataPortalENSG00000135919
TCGA cBioPortalSERPINE2
AceView (NCBI)SERPINE2
Genatlas (Paris)SERPINE2
WikiGenes5270
SOURCE (Princeton)SERPINE2
Genetics Home Reference (NIH)SERPINE2
Genomic and cartography
GoldenPath hg19 (UCSC)SERPINE2  -     chr2:224839765-224904036 -  2q36.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SERPINE2  -     2q36.1   [Description]    (hg38-Dec_2013)
EnsemblSERPINE2 - 2q36.1 [CytoView hg19]  SERPINE2 - 2q36.1 [CytoView hg38]
Mapping of homologs : NCBISERPINE2 [Mapview hg19]  SERPINE2 [Mapview hg38]
OMIM177010   
Gene and transcription
Genbank (Entrez)A03911 AI754402 AJ293400 AK225823 AK295564
RefSeq transcript (Entrez)NM_001136528 NM_001136530 NM_006216
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_032907 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)SERPINE2
Cluster EST : UnigeneHs.708453 [ NCBI ]
CGAP (NCI)Hs.708453
Alternative Splicing GalleryENSG00000135919
Gene ExpressionSERPINE2 [ NCBI-GEO ]   SERPINE2 [ EBI - ARRAY_EXPRESS ]   SERPINE2 [ SEEK ]   SERPINE2 [ MEM ]
Gene Expression Viewer (FireBrowse)SERPINE2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5270
GTEX Portal (Tissue expression)SERPINE2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07093   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07093  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07093
Splice isoforms : SwissVarP07093
PhosPhoSitePlusP07093
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Serpin_CS    Serpin_dom    Serpin_fam   
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
Conserved Domain (NCBI)SERPINE2
DMDM Disease mutations5270
Blocks (Seattle)SERPINE2
PDB (SRS)4DY0    4DY7   
PDB (PDBSum)4DY0    4DY7   
PDB (IMB)4DY0    4DY7   
PDB (RSDB)4DY0    4DY7   
Structural Biology KnowledgeBase4DY0    4DY7   
SCOP (Structural Classification of Proteins)4DY0    4DY7   
CATH (Classification of proteins structures)4DY0    4DY7   
SuperfamilyP07093
Human Protein AtlasENSG00000135919
Peptide AtlasP07093
HPRD01510
IPIIPI00009890   IPI00914848   IPI00917938   IPI00917499   IPI00916528   IPI00916104   
Protein Interaction databases
DIP (DOE-UCLA)P07093
IntAct (EBI)P07093
FunCoupENSG00000135919
BioGRIDSERPINE2
STRING (EMBL)SERPINE2
ZODIACSERPINE2
Ontologies - Pathways
QuickGOP07093
Ontology : AmiGOserine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  receptor binding  protein binding  glycosaminoglycan binding  extracellular region  extracellular region  extracellular space  cytosol  embryo implantation  blood coagulation  heparin binding  negative regulation of cell proliferation  response to radiation  negative regulation of plasminogen activation  negative regulation of sodium ion transport  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  negative regulation of protein processing  positive regulation of neuron projection development  negative regulation of phosphatidylinositol 3-kinase signaling  cerebellar granular layer morphogenesis  negative regulation of blood coagulation  negative regulation of blood coagulation  negative regulation of cell growth  regulation of cell migration  extracellular matrix  platelet alpha granule  platelet alpha granule  extrinsic component of external side of plasma membrane  neuromuscular junction  secretion by cell  secretory granule organization  negative regulation of protein catabolic process  mating plug formation  neuronal cell body  negative regulation of proteolysis  negative regulation of smoothened signaling pathway  regulation of timing of cell differentiation  positive regulation of astrocyte differentiation  detection of mechanical stimulus involved in sensory perception  regulation of synaptic transmission, glutamatergic  long-term synaptic potentiation  innervation  seminal vesicle epithelium development  dense core granule biogenesis  negative regulation of platelet aggregation  extracellular vesicle  
Ontology : EGO-EBIserine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  receptor binding  protein binding  glycosaminoglycan binding  extracellular region  extracellular region  extracellular space  cytosol  embryo implantation  blood coagulation  heparin binding  negative regulation of cell proliferation  response to radiation  negative regulation of plasminogen activation  negative regulation of sodium ion transport  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  negative regulation of protein processing  positive regulation of neuron projection development  negative regulation of phosphatidylinositol 3-kinase signaling  cerebellar granular layer morphogenesis  negative regulation of blood coagulation  negative regulation of blood coagulation  negative regulation of cell growth  regulation of cell migration  extracellular matrix  platelet alpha granule  platelet alpha granule  extrinsic component of external side of plasma membrane  neuromuscular junction  secretion by cell  secretory granule organization  negative regulation of protein catabolic process  mating plug formation  neuronal cell body  negative regulation of proteolysis  negative regulation of smoothened signaling pathway  regulation of timing of cell differentiation  positive regulation of astrocyte differentiation  detection of mechanical stimulus involved in sensory perception  regulation of synaptic transmission, glutamatergic  long-term synaptic potentiation  innervation  seminal vesicle epithelium development  dense core granule biogenesis  negative regulation of platelet aggregation  extracellular vesicle  
NDEx NetworkSERPINE2
Atlas of Cancer Signalling NetworkSERPINE2
Wikipedia pathwaysSERPINE2
Orthology - Evolution
OrthoDB5270
GeneTree (enSembl)ENSG00000135919
Phylogenetic Trees/Animal Genes : TreeFamSERPINE2
HOVERGENP07093
HOGENOMP07093
Homologs : HomoloGeneSERPINE2
Homology/Alignments : Family Browser (UCSC)SERPINE2
Gene fusions - Rearrangements
Fusion : MitelmanSERPINE2/RABEP1 [2q36.1/17p13.2]  
Fusion: TCGASERPINE2 2q36.1 RABEP1 17p13.2 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERPINE2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERPINE2
dbVarSERPINE2
ClinVarSERPINE2
1000_GenomesSERPINE2 
Exome Variant ServerSERPINE2
ExAC (Exome Aggregation Consortium)SERPINE2 (select the gene name)
Genetic variants : HAPMAP5270
Genomic Variants (DGV)SERPINE2 [DGVbeta]
DECIPHER (Syndromes)2:224839765-224904036  ENSG00000135919
CONAN: Copy Number AnalysisSERPINE2 
Mutations
ICGC Data PortalSERPINE2 
TCGA Data PortalSERPINE2 
Broad Tumor PortalSERPINE2
OASIS PortalSERPINE2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERPINE2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSERPINE2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SERPINE2
DgiDB (Drug Gene Interaction Database)SERPINE2
DoCM (Curated mutations)SERPINE2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SERPINE2 (select a term)
intoGenSERPINE2
Cancer3DSERPINE2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM177010   
Orphanet
MedgenSERPINE2
Genetic Testing Registry SERPINE2
NextProtP07093 [Medical]
TSGene5270
GENETestsSERPINE2
Huge Navigator SERPINE2 [HugePedia]
snp3D : Map Gene to Disease5270
BioCentury BCIQSERPINE2
ClinGenSERPINE2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5270
Chemical/Pharm GKB GenePA269
Clinical trialSERPINE2
Miscellaneous
canSAR (ICR)SERPINE2 (select the gene name)
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSERPINE2
EVEXSERPINE2
GoPubMedSERPINE2
iHOPSERPINE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:26:50 CET 2017

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