SERPINE2 (serpin family E member 2)

2007-12-01 Affiliation

Identity

HGNC

SERPINE2

LOCATION

2q36.1

LOCUSID

5270

ALIAS

GDN,GDNPF,PI-7,PI7,PN-1,PN1,PNI

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5270
MIM: 177010
HGNC: 8951
Ensembl: ENSG00000135919

Variants:

dbSNP: 5270
ClinVar: 5270
TCGA: ENSG00000135919
COSMIC: SERPINE2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135919	ENST00000258405	P07093
ENSG00000135919	ENST00000258405	A0A024R451
ENSG00000135919	ENST00000409304	P07093
ENSG00000135919	ENST00000409304	A0A024R498
ENSG00000135919	ENST00000409840	P07093
ENSG00000135919	ENST00000409840	A0A024R498
ENSG00000135919	ENST00000423446	C9JRK5
ENSG00000135919	ENST00000432738	C9JN98
ENSG00000135919	ENST00000447280	P07093
ENSG00000135919	ENST00000454956	C9K031

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Hemostasis	REACTOME	R-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)	REACTOME	R-HSA-140877
Intrinsic Pathway of Fibrin Clot Formation	REACTOME	R-HSA-140837
Common Pathway of Fibrin Clot Formation	REACTOME	R-HSA-140875
Dissolution of Fibrin Clot	REACTOME	R-HSA-75205

References

Pubmed ID	Year	Title	Citations
20805453	2010	Molecular anatomy of breast cancer stroma and its prognostic value in estrogen receptor-positive and -negative cancers.	81
16358219	2006	The SERPINE2 gene is associated with chronic obstructive pulmonary disease.	64
16358219	2006	The SERPINE2 gene is associated with chronic obstructive pulmonary disease.	64
17446335	2007	The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations.	60
17446335	2007	The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations.	60
19584287	2009	The serine protease inhibitor protease nexin-1 controls mammary cancer metastasis through LRP-1-mediated MMP-9 expression.	37
16015279	2006	Brain endothelial hemostasis regulation by pericytes.	34
16085935	2005	Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2.	26
20233420	2010	Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation.	25
17690329	2008	IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency.	23

Citation

Dessen P

SERPINE2 (serpin family E member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49888/serpine2