Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SERPINE3 (serpin family E member 3)

Identity

Alias (NCBI)-
HGNC (Hugo) SERPINE3
HGNC Previous nameserpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
LocusID (NCBI) 647174
Atlas_Id 73148
Location 13q14.3  [Link to chromosome band 13q14]
Location_base_pair Starts at 51341032 and ends at 51362103 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DCLK1 (13q13.3) / SERPINE3 (13q14.3)WDFY2 (13q14.3) / SERPINE3 (13q14.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(13;13)(q13;q14) DCLK1/SERPINE3

External links

Nomenclature
HGNC (Hugo)SERPINE3   24774
Cards
Entrez_Gene (NCBI)SERPINE3  647174  serpin family E member 3
Aliases
GeneCards (Weizmann)SERPINE3
Ensembl hg19 (Hinxton)ENSG00000253309 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000253309 [Gene_View]  ENSG00000253309 [Sequence]  chr13:51341032-51362103 [Contig_View]  SERPINE3 [Vega]
ICGC DataPortalENSG00000253309
TCGA cBioPortalSERPINE3
AceView (NCBI)SERPINE3
Genatlas (Paris)SERPINE3
WikiGenes647174
SOURCE (Princeton)SERPINE3
Genetics Home Reference (NIH)SERPINE3
Genomic and cartography
GoldenPath hg38 (UCSC)SERPINE3  -     chr13:51341032-51362103 +  13q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SERPINE3  -     13q14.3   [Description]    (hg19-Feb_2009)
GoldenPathSERPINE3 - 13q14.3 [CytoView hg19]  SERPINE3 - 13q14.3 [CytoView hg38]
ImmunoBaseENSG00000253309
genome Data Viewer NCBISERPINE3 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AM402969 AX772926
RefSeq transcript (Entrez)NM_001101320
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SERPINE3
Alternative Splicing GalleryENSG00000253309
Gene ExpressionSERPINE3 [ NCBI-GEO ]   SERPINE3 [ EBI - ARRAY_EXPRESS ]   SERPINE3 [ SEEK ]   SERPINE3 [ MEM ]
Gene Expression Viewer (FireBrowse)SERPINE3 [ Firebrowse - Broad ]
GenevisibleExpression of SERPINE3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)647174
GTEX Portal (Tissue expression)SERPINE3
Human Protein AtlasENSG00000253309-SERPINE3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA8MV23   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA8MV23  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA8MV23
Splice isoforms : SwissVarA8MV23
PhosPhoSitePlusA8MV23
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Serpin_CS    Serpin_dom    Serpin_E3    Serpin_fam    Serpin_sf    Serpin_sf_1    Serpin_sf_2   
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
Conserved Domain (NCBI)SERPINE3
DMDM Disease mutations647174
Blocks (Seattle)SERPINE3
SuperfamilyA8MV23
Human Protein Atlas [tissue]ENSG00000253309-SERPINE3 [tissue]
Peptide AtlasA8MV23
IPIIPI00867685   IPI00937326   IPI00981754   
Protein Interaction databases
DIP (DOE-UCLA)A8MV23
IntAct (EBI)A8MV23
FunCoupENSG00000253309
BioGRIDSERPINE3
STRING (EMBL)SERPINE3
ZODIACSERPINE3
Ontologies - Pathways
QuickGOA8MV23
Ontology : AmiGOserine-type endopeptidase inhibitor activity  extracellular space  negative regulation of endopeptidase activity  
Ontology : EGO-EBIserine-type endopeptidase inhibitor activity  extracellular space  negative regulation of endopeptidase activity  
NDEx NetworkSERPINE3
Atlas of Cancer Signalling NetworkSERPINE3
Wikipedia pathwaysSERPINE3
Orthology - Evolution
OrthoDB647174
GeneTree (enSembl)ENSG00000253309
Phylogenetic Trees/Animal Genes : TreeFamSERPINE3
HOGENOMA8MV23
Homologs : HomoloGeneSERPINE3
Homology/Alignments : Family Browser (UCSC)SERPINE3
Gene fusions - Rearrangements
Fusion : QuiverSERPINE3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERPINE3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERPINE3
dbVarSERPINE3
ClinVarSERPINE3
1000_GenomesSERPINE3 
Exome Variant ServerSERPINE3
GNOMAD BrowserENSG00000253309
Varsome BrowserSERPINE3
Genetic variants : HAPMAP647174
Genomic Variants (DGV)SERPINE3 [DGVbeta]
DECIPHERSERPINE3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSERPINE3 
Mutations
ICGC Data PortalSERPINE3 
TCGA Data PortalSERPINE3 
Broad Tumor PortalSERPINE3
OASIS PortalSERPINE3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERPINE3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSERPINE3
Mutations and Diseases : HGMDSERPINE3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SERPINE3
DgiDB (Drug Gene Interaction Database)SERPINE3
DoCM (Curated mutations)SERPINE3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SERPINE3 (select a term)
intoGenSERPINE3
Cancer3DSERPINE3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETSERPINE3
MedgenSERPINE3
Genetic Testing Registry SERPINE3
NextProtA8MV23 [Medical]
TSGene647174
GENETestsSERPINE3
Target ValidationSERPINE3
Huge Navigator SERPINE3 [HugePedia]
snp3D : Map Gene to Disease647174
BioCentury BCIQSERPINE3
ClinGenSERPINE3
Clinical trials, drugs, therapy
Protein Interactions : CTD647174
Pharm GKB GenePA164725650
Clinical trialSERPINE3
Miscellaneous
canSAR (ICR)SERPINE3 (select the gene name)
HarmonizomeSERPINE3
DataMed IndexSERPINE3
Probes
Litterature
PubMed4 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSERPINE3
EVEXSERPINE3
GoPubMedSERPINE3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Aug 22 19:34:08 CEST 2020
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