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SERPINF1 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1)

Identity

Other namesEPC-1
OI12
OI6
PEDF
HGNC (Hugo) SERPINF1
LocusID (NCBI) 5176
Location 17p13.3
Location_base_pair Starts at 1665259 and ends at 1680859 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SERPINF1   8824
Cards
Entrez_Gene (NCBI)SERPINF1  5176  serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
GeneCards (Weizmann)SERPINF1
Ensembl hg19 (Hinxton)ENSG00000132386 [Gene_View]  chr17:1665259-1680859 [Contig_View]  SERPINF1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000132386 [Gene_View]  chr17:1665259-1680859 [Contig_View]  SERPINF1 [Vega]
ICGC DataPortalENSG00000132386
cBioPortalSERPINF1
AceView (NCBI)SERPINF1
Genatlas (Paris)SERPINF1
WikiGenes5176
SOURCE (Princeton)SERPINF1
Genomic and cartography
GoldenPath hg19 (UCSC)SERPINF1  -     chr17:1665259-1680859 +  17p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SERPINF1  -     17p13.3   [Description]    (hg38-Dec_2013)
EnsemblSERPINF1 - 17p13.3 [CytoView hg19]  SERPINF1 - 17p13.3 [CytoView hg38]
Mapping of homologs : NCBISERPINF1 [Mapview hg19]  SERPINF1 [Mapview hg38]
OMIM172860   613982   
Gene and transcription
Genbank (Entrez)AA351026 AA658568 AB593011 AB593012 AB593013
RefSeq transcript (Entrez)NM_002615
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_028180 NT_010718 NW_001838403 NW_004929405
Consensus coding sequences : CCDS (NCBI)SERPINF1
Cluster EST : UnigeneHs.532768 [ NCBI ]
CGAP (NCI)Hs.532768
Alternative Splicing : Fast-db (Paris)GSHG0012114
Alternative Splicing GalleryENSG00000132386
Gene ExpressionSERPINF1 [ NCBI-GEO ]     SERPINF1 [ SEEK ]   SERPINF1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36955 (Uniprot)
NextProtP36955  [Medical]
With graphics : InterProP36955
Splice isoforms : SwissVarP36955 (Swissvar)
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Serpin_CS    Serpin_dom    Serpin_fam   
Related proteins : CluSTrP36955
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
DMDM Disease mutations5176
Blocks (Seattle)P36955
PDB (SRS)1IMV   
PDB (PDBSum)1IMV   
PDB (IMB)1IMV   
PDB (RSDB)1IMV   
Human Protein AtlasENSG00000132386
Peptide AtlasP36955
HPRD01408
IPIIPI00006114   
Protein Interaction databases
DIP (DOE-UCLA)P36955
IntAct (EBI)P36955
FunCoupENSG00000132386
BioGRIDSERPINF1
IntegromeDBSERPINF1
STRING (EMBL)SERPINF1
Ontologies - Pathways
QuickGOP36955
Ontology : AmiGOkidney development  serine-type endopeptidase inhibitor activity  extracellular region  extracellular space  multicellular organismal development  aging  short-term memory  cell proliferation  negative regulation of endopeptidase activity  negative regulation of angiogenesis  regulation of proteolysis  extracellular matrix  response to retinoic acid  melanosome  negative regulation of inflammatory response  positive regulation of neurogenesis  response to glucocorticoid  negative regulation of epithelial cell proliferation involved in prostate gland development  extracellular vesicular exosome  
Ontology : EGO-EBIkidney development  serine-type endopeptidase inhibitor activity  extracellular region  extracellular space  multicellular organismal development  aging  short-term memory  cell proliferation  negative regulation of endopeptidase activity  negative regulation of angiogenesis  regulation of proteolysis  extracellular matrix  response to retinoic acid  melanosome  negative regulation of inflammatory response  positive regulation of neurogenesis  response to glucocorticoid  negative regulation of epithelial cell proliferation involved in prostate gland development  extracellular vesicular exosome  
Protein Interaction DatabaseSERPINF1
DoCM (Curated mutations)SERPINF1
Wikipedia pathwaysSERPINF1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerSERPINF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERPINF1
dbVarSERPINF1
ClinVarSERPINF1
1000_GenomesSERPINF1 
Exome Variant ServerSERPINF1
SNP (GeneSNP Utah)SERPINF1
SNP : HGBaseSERPINF1
Genetic variants : HAPMAPSERPINF1
Genomic VariantsSERPINF1  SERPINF1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000132386 
Somatic Mutations in Cancer : COSMICSERPINF1 
CONAN: Copy Number AnalysisSERPINF1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Osteogenesis Imperfecta Variant Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:1665259-1680859
Mutations and Diseases : HGMDSERPINF1
OMIM172860    613982   
MedgenSERPINF1
NextProtP36955 [Medical]
GENETestsSERPINF1
Disease Genetic AssociationSERPINF1
Huge Navigator SERPINF1 [HugePedia]  SERPINF1 [HugeCancerGEM]
snp3D : Map Gene to Disease5176
DGIdb (Drug Gene Interaction db)SERPINF1
General knowledge
Homologs : HomoloGeneSERPINF1
Homology/Alignments : Family Browser (UCSC)SERPINF1
Phylogenetic Trees/Animal Genes : TreeFamSERPINF1
Chemical/Protein Interactions : CTD5176
Chemical/Pharm GKB GenePA35508
Clinical trialSERPINF1
Cancer Resource (Charite)ENSG00000132386
Other databases
Probes
Litterature
PubMed196 Pubmed reference(s) in Entrez
CoreMineSERPINF1
GoPubMedSERPINF1
iHOPSERPINF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 01:22:33 CET 2014
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