Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SERPINF2 (serpin family F member 2)

Identity

Alias_namesPLI
serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Alias_symbol (synonym)API
ALPHA-2-PI
A2AP
AAP
HGNC (Hugo) SERPINF2
LocusID (NCBI) 5345
Atlas_Id 47650
Location 17p13.3  [Link to chromosome band 17p13]
Location_base_pair Starts at 1646130 and ends at 1658559 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SERPINF2 (17p13.3) / HPS3 (3q24)SERPINF2 (17p13.3) / MALT1 (18q21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SERPINF2   9075
LRG (Locus Reference Genomic)LRG_885
Cards
Entrez_Gene (NCBI)SERPINF2  5345  serpin family F member 2
AliasesA2AP; AAP; ALPHA-2-PI; API; 
PLI
GeneCards (Weizmann)SERPINF2
Ensembl hg19 (Hinxton)ENSG00000167711 [Gene_View]  chr17:1646130-1658559 [Contig_View]  SERPINF2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000167711 [Gene_View]  chr17:1646130-1658559 [Contig_View]  SERPINF2 [Vega]
ICGC DataPortalENSG00000167711
TCGA cBioPortalSERPINF2
AceView (NCBI)SERPINF2
Genatlas (Paris)SERPINF2
WikiGenes5345
SOURCE (Princeton)SERPINF2
Genetics Home Reference (NIH)SERPINF2
Genomic and cartography
GoldenPath hg19 (UCSC)SERPINF2  -     chr17:1646130-1658559 +  17p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SERPINF2  -     17p13.3   [Description]    (hg38-Dec_2013)
EnsemblSERPINF2 - 17p13.3 [CytoView hg19]  SERPINF2 - 17p13.3 [CytoView hg38]
Mapping of homologs : NCBISERPINF2 [Mapview hg19]  SERPINF2 [Mapview hg38]
OMIM262850   613168   
Gene and transcription
Genbank (Entrez)AK303763 AL564784 BC031592 BX107460 CK300825
RefSeq transcript (Entrez)NM_000934 NM_001165920 NM_001165921
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_013215 NT_010718 NT_187611 NW_004929405
Consensus coding sequences : CCDS (NCBI)SERPINF2
Cluster EST : UnigeneHs.159509 [ NCBI ]
CGAP (NCI)Hs.159509
Alternative Splicing GalleryENSG00000167711
Gene ExpressionSERPINF2 [ NCBI-GEO ]   SERPINF2 [ EBI - ARRAY_EXPRESS ]   SERPINF2 [ SEEK ]   SERPINF2 [ MEM ]
Gene Expression Viewer (FireBrowse)SERPINF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5345
GTEX Portal (Tissue expression)SERPINF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08697   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08697  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08697
Splice isoforms : SwissVarP08697
PhosPhoSitePlusP08697
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Serpin_CS    Serpin_dom    Serpin_fam   
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
Conserved Domain (NCBI)SERPINF2
DMDM Disease mutations5345
Blocks (Seattle)SERPINF2
SuperfamilyP08697
Human Protein AtlasENSG00000167711
Peptide AtlasP08697
HPRD02029
IPIIPI00879231   IPI00879608   IPI00879937   IPI00877925   
Protein Interaction databases
DIP (DOE-UCLA)P08697
IntAct (EBI)P08697
FunCoupENSG00000167711
BioGRIDSERPINF2
STRING (EMBL)SERPINF2
ZODIACSERPINF2
Ontologies - Pathways
QuickGOP08697
Ontology : AmiGOprotease binding  regulation of blood vessel size by renin-angiotensin  platelet degranulation  endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  extracellular region  fibrinogen complex  extracellular space  acute-phase response  cell surface  response to organic substance  negative regulation of plasminogen activation  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  collagen fibril organization  platelet alpha granule lumen  positive regulation of collagen biosynthetic process  fibrinolysis  protein homodimerization activity  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  blood vessel morphogenesis  positive regulation of smooth muscle cell proliferation  positive regulation of stress fiber assembly  negative regulation of fibrinolysis  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  positive regulation of transforming growth factor beta production  blood microparticle  positive regulation of cell-cell adhesion mediated by cadherin  
Ontology : EGO-EBIprotease binding  regulation of blood vessel size by renin-angiotensin  platelet degranulation  endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  extracellular region  fibrinogen complex  extracellular space  acute-phase response  cell surface  response to organic substance  negative regulation of plasminogen activation  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  collagen fibril organization  platelet alpha granule lumen  positive regulation of collagen biosynthetic process  fibrinolysis  protein homodimerization activity  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  blood vessel morphogenesis  positive regulation of smooth muscle cell proliferation  positive regulation of stress fiber assembly  negative regulation of fibrinolysis  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  positive regulation of transforming growth factor beta production  blood microparticle  positive regulation of cell-cell adhesion mediated by cadherin  
Pathways : KEGGComplement and coagulation cascades   
NDEx NetworkSERPINF2
Atlas of Cancer Signalling NetworkSERPINF2
Wikipedia pathwaysSERPINF2
Orthology - Evolution
OrthoDB5345
GeneTree (enSembl)ENSG00000167711
Phylogenetic Trees/Animal Genes : TreeFamSERPINF2
HOVERGENP08697
HOGENOMP08697
Homologs : HomoloGeneSERPINF2
Homology/Alignments : Family Browser (UCSC)SERPINF2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERPINF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERPINF2
dbVarSERPINF2
ClinVarSERPINF2
1000_GenomesSERPINF2 
Exome Variant ServerSERPINF2
ExAC (Exome Aggregation Consortium)SERPINF2 (select the gene name)
Genetic variants : HAPMAP5345
Genomic Variants (DGV)SERPINF2 [DGVbeta]
DECIPHER (Syndromes)17:1646130-1658559  ENSG00000167711
CONAN: Copy Number AnalysisSERPINF2 
Mutations
ICGC Data PortalSERPINF2 
TCGA Data PortalSERPINF2 
Broad Tumor PortalSERPINF2
OASIS PortalSERPINF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERPINF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSERPINF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SERPINF2
DgiDB (Drug Gene Interaction Database)SERPINF2
DoCM (Curated mutations)SERPINF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SERPINF2 (select a term)
intoGenSERPINF2
Cancer3DSERPINF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM262850    613168   
Orphanet3335   
MedgenSERPINF2
Genetic Testing Registry SERPINF2
NextProtP08697 [Medical]
TSGene5345
GENETestsSERPINF2
Huge Navigator SERPINF2 [HugePedia]
snp3D : Map Gene to Disease5345
BioCentury BCIQSERPINF2
ClinGenSERPINF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5345
Chemical/Pharm GKB GenePA35522
Clinical trialSERPINF2
Miscellaneous
canSAR (ICR)SERPINF2 (select the gene name)
Probes
Litterature
PubMed92 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSERPINF2
EVEXSERPINF2
GoPubMedSERPINF2
iHOPSERPINF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:51:03 CET 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.