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SERPINF2 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2)

Identity

Other namesA2AP
AAP
ALPHA-2-PI
API
PLI
HGNC (Hugo) SERPINF2
LocusID (NCBI) 5345
Location 17p13.3
Location_base_pair Starts at 1646130 and ends at 1658559 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SERPINF2   9075
Cards
Entrez_Gene (NCBI)SERPINF2  5345  serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
GeneCards (Weizmann)SERPINF2
Ensembl (Hinxton)ENSG00000167711 [Gene_View]  chr17:1646130-1658559 [Contig_View]  SERPINF2 [Vega]
ICGC DataPortalENSG00000167711
AceView (NCBI)SERPINF2
Genatlas (Paris)SERPINF2
WikiGenes5345
SOURCE (Princeton)NM_000934 NM_001165920 NM_001165921
Genomic and cartography
GoldenPath (UCSC)SERPINF2  -  17p13.3   chr17:1646130-1658559 +  17p13.3   [Description]    (hg19-Feb_2009)
EnsemblSERPINF2 - 17p13.3 [CytoView]
Mapping of homologs : NCBISERPINF2 [Mapview]
OMIM262850   613168   
Gene and transcription
Genbank (Entrez)AK303763 AL564784 BC031592 BX107460 CK300825
RefSeq transcript (Entrez)NM_000934 NM_001165920 NM_001165921
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_013215 NT_010718 NT_187611 NW_001838403 NW_004929405
Consensus coding sequences : CCDS (NCBI)SERPINF2
Cluster EST : UnigeneHs.159509 [ NCBI ]
CGAP (NCI)Hs.159509
Alternative Splicing : Fast-db (Paris)GSHG0012113
Alternative Splicing GalleryENSG00000167711
Gene ExpressionSERPINF2 [ NCBI-GEO ]     SERPINF2 [ SEEK ]   SERPINF2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08697 (Uniprot)
NextProtP08697  [Medical]
With graphics : InterProP08697
Splice isoforms : SwissVarP08697 (Swissvar)
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Serpin_CS    Serpin_dom    Serpin_fam   
Related proteins : CluSTrP08697
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
DMDM Disease mutations5345
Blocks (Seattle)P08697
Human Protein AtlasENSG00000167711
Peptide AtlasP08697
HPRD02029
IPIIPI00879231   IPI00879608   IPI00879937   IPI00877925   
Protein Interaction databases
DIP (DOE-UCLA)P08697
IntAct (EBI)P08697
FunCoupENSG00000167711
BioGRIDSERPINF2
IntegromeDBSERPINF2
STRING (EMBL)SERPINF2
Ontologies - Pathways
QuickGOP08697
Ontology : AmiGOprotease binding  regulation of blood vessel size by renin-angiotensin  platelet degranulation  endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  extracellular region  fibrinogen complex  extracellular space  extracellular space  acute-phase response  blood coagulation  cell surface  response to organic substance  negative regulation of plasminogen activation  negative regulation of endopeptidase activity  regulation of proteolysis  platelet activation  collagen fibril organization  platelet alpha granule lumen  positive regulation of collagen biosynthetic process  fibrinolysis  protein homodimerization activity  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  blood vessel morphogenesis  positive regulation of smooth muscle cell proliferation  positive regulation of stress fiber assembly  negative regulation of fibrinolysis  extracellular vesicular exosome  positive regulation of ERK1 and ERK2 cascade  positive regulation of transforming growth factor beta production  blood microparticle  positive regulation of cell-cell adhesion mediated by cadherin  
Ontology : EGO-EBIprotease binding  regulation of blood vessel size by renin-angiotensin  platelet degranulation  endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  extracellular region  fibrinogen complex  extracellular space  extracellular space  acute-phase response  blood coagulation  cell surface  response to organic substance  negative regulation of plasminogen activation  negative regulation of endopeptidase activity  regulation of proteolysis  platelet activation  collagen fibril organization  platelet alpha granule lumen  positive regulation of collagen biosynthetic process  fibrinolysis  protein homodimerization activity  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  blood vessel morphogenesis  positive regulation of smooth muscle cell proliferation  positive regulation of stress fiber assembly  negative regulation of fibrinolysis  extracellular vesicular exosome  positive regulation of ERK1 and ERK2 cascade  positive regulation of transforming growth factor beta production  blood microparticle  positive regulation of cell-cell adhesion mediated by cadherin  
Pathways : KEGGComplement and coagulation cascades   
Protein Interaction DatabaseSERPINF2
Wikipedia pathwaysSERPINF2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SERPINF2
SNP (GeneSNP Utah)SERPINF2
SNP : HGBaseSERPINF2
Genetic variants : HAPMAPSERPINF2
1000_GenomesSERPINF2 
ICGC programENSG00000167711 
CONAN: Copy Number AnalysisSERPINF2 
Somatic Mutations in Cancer : COSMICSERPINF2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
DECIPHER (Syndromes)17:1646130-1658559
Mutations and Diseases : HGMDSERPINF2
OMIM262850    613168   
MedgenSERPINF2
GENETestsSERPINF2
Disease Genetic AssociationSERPINF2
Huge Navigator SERPINF2 [HugePedia]  SERPINF2 [HugeCancerGEM]
Genomic VariantsSERPINF2  SERPINF2 [DGVbeta]
Exome VariantSERPINF2
dbVarSERPINF2
ClinVarSERPINF2
snp3D : Map Gene to Disease5345
General knowledge
Homologs : HomoloGeneSERPINF2
Homology/Alignments : Family Browser (UCSC)SERPINF2
Phylogenetic Trees/Animal Genes : TreeFamSERPINF2
Chemical/Protein Interactions : CTD5345
Chemical/Pharm GKB GenePA35522
Clinical trialSERPINF2
Cancer Resource (Charite)ENSG00000167711
Other databases
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
CoreMineSERPINF2
GoPubMedSERPINF2
iHOPSERPINF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 17:56:02 CET 2014

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