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SERPINF2 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2)

Identity

Other namesA2AP
AAP
ALPHA-2-PI
API
PLI
HGNC (Hugo) SERPINF2
LocusID (NCBI) 5345
Location 17p13.3
Location_base_pair Starts at 1646130 and ends at 1658559 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SERPINF2   9075
Entrez_Gene (NCBI)SERPINF2  5345  serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Cards
GeneCards (Weizmann)SERPINF2
Ensembl (Hinxton)ENSG00000167711 [Gene_View]  chr17:1646130-1658559 [Contig_View]  SERPINF2 [Vega]
AceView (NCBI)SERPINF2
Genatlas (Paris)SERPINF2
SOURCE (Stanford)NM_000934 NM_001165920 NM_001165921
Genomic and cartography
GoldenPath (UCSC)SERPINF2  -  17p13.3   chr17:1646130-1658559 +  17p13.3   [Description]    (hg19-Feb_2009)
EnsemblSERPINF2 - 17p13.3 [CytoView]
Mapping of homologs : NCBISERPINF2 [Mapview]
OMIM262850   613168   
Gene and transcription
Genbank (Entrez)AK303763 AL564784 BC031592 BX107460 CK300825
RefSeq transcript (SRS)NM_000934 NM_001165920 NM_001165921
RefSeq transcript (Entrez)NM_000934 NM_001165920 NM_001165921
RefSeq genomic (SRS)AC_000149 NC_000017 NC_018928 NG_013215 NT_010718 NW_001838403 NW_004078090
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_013215 NT_010718 NW_001838403 NW_004078090
Consensus coding sequences : CCDS (NCBI)SERPINF2
Cluster EST : UnigeneHs.159509 [ SRS ] Hs.159509 [ NCBI ]
CGAP (NCI)Hs.159509
Alternative Splicing : Fast-db (Paris)GSHG0012113
Alternative Splicing GalleryENSG00000167711
Gene ExpressionSERPINF2 [ NCBI-GEO ]   SERPINF2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08697 (SRS) P08697 (Uniprot)
NextProtP08697
With graphics : InterProP08697
Splice isoforms : SwissVarP08697(Swissvar)
Domaine pattern : Prosite (SRS)SERPIN (PS00284)   
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (SRS)Protease_inhib_I4_serpin_CS    Serpin_dom    Serpin_fam   
Domains : Interpro (EBI)Protease_inhib_I4_serpin_CS    Serpin_dom    Serpin_fam   
Related proteins : CluSTrP08697
Domain families : Pfam (SRS)Serpin (PF00079)   
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
DMDM5345
Blocks (Seattle)P08697
Human Protein AtlasENSG00000167711
HPRD02029
IPIIPI00879231   IPI00879608   IPI00879937   IPI00877925   
Protein Interaction databases
DIP (DOE-UCLA)P08697
IntAct (EBI)P08697
FunCoupENSG00000167711
REACTOMESERPINF2
Protein Interaction Database5345
BioGRIDSERPINF2
InParanoidP08697
Interologous Interaction database P08697
IntegromeDBSERPINF2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SERPINF2
SNP (GeneSNP Utah)SERPINF2
SNP : HGBaseSERPINF2
Genetic variants : HAPMAPSERPINF2
Somatic Mutations in Cancer : COSMICSERPINF2 
CONAN: Copy Number AnalysisSERPINF2 
Mutations and Diseases : HGMDSERPINF2
OMIM262850    613168   
GENETests262850    613168   
Disease Genetic AssociationSERPINF2
Huge Navigator SERPINF2 [HugePedia]  SERPINF2 [HugeCancerGEM]
Genomic VariantsSERPINF2  SERPINF2 [DGVbeta]
snp3D : Map Gene to Disease5345
General knowledge
Homologs : HomoloGeneSERPINF2
Homology/Alignments : Family Browser (UCSC)SERPINF2
Phylogenetic Trees/Animal Genes : TreeFamSERPINF2
Chemical/Protein Interactions : CTD5345
Chemical/Pharm GKB GenePA35522
Clinical trialSERPINF2
Cancer Resource (Charite)ENSG00000167711
Ontology : AmiGOprotease binding  regulation of blood vessel size by renin-angiotensin  platelet degranulation  endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  extracellular region  fibrinogen complex  extracellular space  extracellular space  acute-phase response  blood coagulation  response to organic substance  negative regulation of plasminogen activation  negative regulation of endopeptidase activity  regulation of proteolysis  platelet activation  collagen fibril organization  platelet alpha granule lumen  positive regulation of collagen biosynthetic process  fibrinolysis  protein homodimerization activity  eukaryotic cell surface binding  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  blood vessel morphogenesis  positive regulation of smooth muscle cell proliferation  positive regulation of stress fiber assembly  negative regulation of fibrinolysis  positive regulation of ERK1 and ERK2 cascade  positive regulation of transforming growth factor beta production  positive regulation of cell-cell adhesion mediated by cadherin  
Ontology : EGO-EBIprotease binding  regulation of blood vessel size by renin-angiotensin  platelet degranulation  endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  extracellular region  fibrinogen complex  extracellular space  extracellular space  acute-phase response  blood coagulation  response to organic substance  negative regulation of plasminogen activation  negative regulation of endopeptidase activity  regulation of proteolysis  platelet activation  collagen fibril organization  platelet alpha granule lumen  positive regulation of collagen biosynthetic process  fibrinolysis  protein homodimerization activity  eukaryotic cell surface binding  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  blood vessel morphogenesis  positive regulation of smooth muscle cell proliferation  positive regulation of stress fiber assembly  negative regulation of fibrinolysis  positive regulation of ERK1 and ERK2 cascade  positive regulation of transforming growth factor beta production  positive regulation of cell-cell adhesion mediated by cadherin  
Pathways : KEGGComplement and coagulation cascades
Other databases
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
PubGeneSERPINF2
iHOPSERPINF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:33:23 CEST 2013
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