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SERPINI1 (serpin family I member 1)

Identity

Alias_namesPI12
serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
Alias_symbol (synonym)neuroserpin
Other alias
HGNC (Hugo) SERPINI1
LocusID (NCBI) 5274
Atlas_Id 55287
Location 3q26.1  [Link to chromosome band 3q26]
Location_base_pair Starts at 167735644 and ends at 167825569 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SERPINI1 (3q26.1) / NAALADL2 (3q26.31)SERPINI1 3q26.1 / NAALADL2 3q26.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SERPINI1   8943
Cards
Entrez_Gene (NCBI)SERPINI1  5274  serpin family I member 1
AliasesPI12; neuroserpin
GeneCards (Weizmann)SERPINI1
Ensembl hg19 (Hinxton)ENSG00000163536 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163536 [Gene_View]  chr3:167735644-167825569 [Contig_View]  SERPINI1 [Vega]
ICGC DataPortalENSG00000163536
TCGA cBioPortalSERPINI1
AceView (NCBI)SERPINI1
Genatlas (Paris)SERPINI1
WikiGenes5274
SOURCE (Princeton)SERPINI1
Genetics Home Reference (NIH)SERPINI1
Genomic and cartography
GoldenPath hg38 (UCSC)SERPINI1  -     chr3:167735644-167825569 +  3q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SERPINI1  -     3q26.1   [Description]    (hg19-Feb_2009)
EnsemblSERPINI1 - 3q26.1 [CytoView hg19]  SERPINI1 - 3q26.1 [CytoView hg38]
Mapping of homologs : NCBISERPINI1 [Mapview hg19]  SERPINI1 [Mapview hg38]
OMIM602445   604218   
Gene and transcription
Genbank (Entrez)AK290082 BC018043 BQ086144 CR627434 DA270615
RefSeq transcript (Entrez)NM_001122752 NM_005025
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SERPINI1
Cluster EST : UnigeneHs.478153 [ NCBI ]
CGAP (NCI)Hs.478153
Alternative Splicing GalleryENSG00000163536
Gene ExpressionSERPINI1 [ NCBI-GEO ]   SERPINI1 [ EBI - ARRAY_EXPRESS ]   SERPINI1 [ SEEK ]   SERPINI1 [ MEM ]
Gene Expression Viewer (FireBrowse)SERPINI1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5274
GTEX Portal (Tissue expression)SERPINI1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99574   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99574  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99574
Splice isoforms : SwissVarQ99574
PhosPhoSitePlusQ99574
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Serpin_CS    Serpin_dom    Serpin_fam   
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
Conserved Domain (NCBI)SERPINI1
DMDM Disease mutations5274
Blocks (Seattle)SERPINI1
PDB (SRS)3F02    3F5N    3FGQ   
PDB (PDBSum)3F02    3F5N    3FGQ   
PDB (IMB)3F02    3F5N    3FGQ   
PDB (RSDB)3F02    3F5N    3FGQ   
Structural Biology KnowledgeBase3F02    3F5N    3FGQ   
SCOP (Structural Classification of Proteins)3F02    3F5N    3FGQ   
CATH (Classification of proteins structures)3F02    3F5N    3FGQ   
SuperfamilyQ99574
Human Protein AtlasENSG00000163536
Peptide AtlasQ99574
HPRD03901
IPIIPI00016150   IPI00945428   IPI00947261   IPI00947198   IPI00796813   
Protein Interaction databases
DIP (DOE-UCLA)Q99574
IntAct (EBI)Q99574
FunCoupENSG00000163536
BioGRIDSERPINI1
STRING (EMBL)SERPINI1
ZODIACSERPINI1
Ontologies - Pathways
QuickGOQ99574
Ontology : AmiGOserine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  extracellular space  extracellular space  central nervous system development  peripheral nervous system development  negative regulation of endopeptidase activity  positive regulation of neuron projection development  regulation of cell adhesion  secretory granule lumen  neuronal cell body  cytoplasmic vesicle lumen  extracellular exosome  
Ontology : EGO-EBIserine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  extracellular space  extracellular space  central nervous system development  peripheral nervous system development  negative regulation of endopeptidase activity  positive regulation of neuron projection development  regulation of cell adhesion  secretory granule lumen  neuronal cell body  cytoplasmic vesicle lumen  extracellular exosome  
NDEx NetworkSERPINI1
Atlas of Cancer Signalling NetworkSERPINI1
Wikipedia pathwaysSERPINI1
Orthology - Evolution
OrthoDB5274
GeneTree (enSembl)ENSG00000163536
Phylogenetic Trees/Animal Genes : TreeFamSERPINI1
HOVERGENQ99574
HOGENOMQ99574
Homologs : HomoloGeneSERPINI1
Homology/Alignments : Family Browser (UCSC)SERPINI1
Gene fusions - Rearrangements
Fusion : MitelmanSERPINI1/NAALADL2 [3q26.1/3q26.31]  
Fusion: TCGASERPINI1 3q26.1 NAALADL2 3q26.31 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERPINI1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERPINI1
dbVarSERPINI1
ClinVarSERPINI1
1000_GenomesSERPINI1 
Exome Variant ServerSERPINI1
ExAC (Exome Aggregation Consortium)SERPINI1 (select the gene name)
Genetic variants : HAPMAP5274
Genomic Variants (DGV)SERPINI1 [DGVbeta]
DECIPHERSERPINI1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSERPINI1 
Mutations
ICGC Data PortalSERPINI1 
TCGA Data PortalSERPINI1 
Broad Tumor PortalSERPINI1
OASIS PortalSERPINI1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERPINI1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSERPINI1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SERPINI1
DgiDB (Drug Gene Interaction Database)SERPINI1
DoCM (Curated mutations)SERPINI1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SERPINI1 (select a term)
intoGenSERPINI1
Cancer3DSERPINI1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602445    604218   
Orphanet11622   
MedgenSERPINI1
Genetic Testing Registry SERPINI1
NextProtQ99574 [Medical]
TSGene5274
GENETestsSERPINI1
Huge Navigator SERPINI1 [HugePedia]
snp3D : Map Gene to Disease5274
BioCentury BCIQSERPINI1
ClinGenSERPINI1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5274
Chemical/Pharm GKB GenePA35511
Clinical trialSERPINI1
Miscellaneous
canSAR (ICR)SERPINI1 (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSERPINI1
EVEXSERPINI1
GoPubMedSERPINI1
iHOPSERPINI1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:36:45 CEST 2017

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