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SERPINI2 (serpin family I member 2)

Identity

Alias (NCBI)MEPI
PANCPIN
PI14
TSA2004
HGNC (Hugo) SERPINI2
HGNC Alias symbTSA2004
MEPI
HGNC Alias namemyoepithelium-derived serine proteinase inhibitor
 pancpin
HGNC Previous namePI14
HGNC Previous nameserine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2
 serine (or cysteine) proteinase inhibitor, clade I (pancpin), member 2
 serpin peptidase inhibitor, clade I (pancpin), member 2
LocusID (NCBI) 5276
Atlas_Id 42269
Location 3q26.1  [Link to chromosome band 3q26]
Location_base_pair Starts at 167441789 and ends at 167474132 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MED13L (12q24.21) / SERPINI2 (3q26.1)SERPINI2 (3q26.1) / MED13L (12q24.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SERPINI2   8945
Cards
Entrez_Gene (NCBI)SERPINI2    serpin family I member 2
AliasesMEPI; PANCPIN; PI14; TSA2004
GeneCards (Weizmann)SERPINI2
Ensembl hg19 (Hinxton)ENSG00000114204 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114204 [Gene_View]  ENSG00000114204 [Sequence]  chr3:167441789-167474132 [Contig_View]  SERPINI2 [Vega]
ICGC DataPortalENSG00000114204
TCGA cBioPortalSERPINI2
AceView (NCBI)SERPINI2
Genatlas (Paris)SERPINI2
SOURCE (Princeton)SERPINI2
Genetics Home Reference (NIH)SERPINI2
Genomic and cartography
GoldenPath hg38 (UCSC)SERPINI2  -     chr3:167441789-167474132 -  3q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SERPINI2  -     3q26.1   [Description]    (hg19-Feb_2009)
GoldenPathSERPINI2 - 3q26.1 [CytoView hg19]  SERPINI2 - 3q26.1 [CytoView hg38]
ImmunoBaseENSG00000114204
Genome Data Viewer NCBISERPINI2 [Mapview hg19]  
OMIM605587   
Gene and transcription
Genbank (Entrez)AB006423 AF130470 AK226025 AK293391 BC027859
RefSeq transcript (Entrez)NM_001012303 NM_001394327 NM_006217
Consensus coding sequences : CCDS (NCBI)SERPINI2
Gene ExpressionSERPINI2 [ NCBI-GEO ]   SERPINI2 [ EBI - ARRAY_EXPRESS ]   SERPINI2 [ SEEK ]   SERPINI2 [ MEM ]
Gene Expression Viewer (FireBrowse)SERPINI2 [ Firebrowse - Broad ]
GenevisibleExpression of SERPINI2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5276
GTEX Portal (Tissue expression)SERPINI2
Human Protein AtlasENSG00000114204-SERPINI2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75830   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75830  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75830
PhosPhoSitePlusO75830
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Serpin_CS    Serpin_dom    Serpin_fam    Serpin_sf    Serpin_sf_1    Serpin_sf_2   
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
Conserved Domain (NCBI)SERPINI2
SuperfamilyO75830
AlphaFold pdb e-kbO75830   
Human Protein Atlas [tissue]ENSG00000114204-SERPINI2 [tissue]
HPRD05722
Protein Interaction databases
DIP (DOE-UCLA)O75830
IntAct (EBI)O75830
BioGRIDSERPINI2
STRING (EMBL)SERPINI2
ZODIACSERPINI2
Ontologies - Pathways
QuickGOO75830
Ontology : AmiGOserine-type endopeptidase inhibitor activity  protein binding  extracellular space  negative regulation of endopeptidase activity  regulation of cell adhesion  extracellular exosome  
Ontology : EGO-EBIserine-type endopeptidase inhibitor activity  protein binding  extracellular space  negative regulation of endopeptidase activity  regulation of cell adhesion  extracellular exosome  
NDEx NetworkSERPINI2
Atlas of Cancer Signalling NetworkSERPINI2
Wikipedia pathwaysSERPINI2
Orthology - Evolution
OrthoDB5276
GeneTree (enSembl)ENSG00000114204
Phylogenetic Trees/Animal Genes : TreeFamSERPINI2
Homologs : HomoloGeneSERPINI2
Homology/Alignments : Family Browser (UCSC)SERPINI2
Gene fusions - Rearrangements
Fusion : QuiverSERPINI2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERPINI2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERPINI2
dbVarSERPINI2
ClinVarSERPINI2
MonarchSERPINI2
1000_GenomesSERPINI2 
Exome Variant ServerSERPINI2
GNOMAD BrowserENSG00000114204
Varsome BrowserSERPINI2
ACMGSERPINI2 variants
VarityO75830
Genomic Variants (DGV)SERPINI2 [DGVbeta]
DECIPHERSERPINI2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSERPINI2 
Mutations
ICGC Data PortalSERPINI2 
TCGA Data PortalSERPINI2 
Broad Tumor PortalSERPINI2
OASIS PortalSERPINI2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERPINI2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSERPINI2
Mutations and Diseases : HGMDSERPINI2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSERPINI2
DgiDB (Drug Gene Interaction Database)SERPINI2
DoCM (Curated mutations)SERPINI2
CIViC (Clinical Interpretations of Variants in Cancer)SERPINI2
Cancer3DSERPINI2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605587   
Orphanet
DisGeNETSERPINI2
MedgenSERPINI2
Genetic Testing Registry SERPINI2
NextProtO75830 [Medical]
GENETestsSERPINI2
Target ValidationSERPINI2
Huge Navigator SERPINI2 [HugePedia]
ClinGenSERPINI2
Clinical trials, drugs, therapy
MyCancerGenomeSERPINI2
Protein Interactions : CTDSERPINI2
Pharm GKB GenePA35513
PharosO75830
Clinical trialSERPINI2
Miscellaneous
canSAR (ICR)SERPINI2
HarmonizomeSERPINI2
DataMed IndexSERPINI2
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSERPINI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:30:44 CEST 2021

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