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SESN1 (sestrin 1)

Identity

Alias_symbol (synonym)SEST1
PA26
Other alias
HGNC (Hugo) SESN1
LocusID (NCBI) 27244
Atlas_Id 42271
Location 6q21  [Link to chromosome band 6q21]
Location_base_pair Starts at 108986437 and ends at 109094505 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GPATCH8 (17q21.31) / SESN1 (6q21)SESN1 (6q21) / AIM1 (6q21)SESN1 (6q21) / ECHDC1 (6q22.33)
SESN1 (6q21) / EYS (6q12)SESN1 (6q21) / MGST2 (4q31.1)SESN1 (6q21) / SESN1 (6q21)
SESN1 6q21 / AIM1 6q21SESN1 6q21 / ECHDC1 6q22.33SESN1 6q21 / EYS 6q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(4;6)(q31;q21) SESN1/MGST2
t(6;6)(q21;q22) SESN1/ECHDC1


External links

Nomenclature
HGNC (Hugo)SESN1   21595
Cards
Entrez_Gene (NCBI)SESN1  27244  sestrin 1
AliasesPA26; SEST1
GeneCards (Weizmann)SESN1
Ensembl hg19 (Hinxton)ENSG00000080546 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000080546 [Gene_View]  ENSG00000080546 [Sequence]  chr6:108986437-109094505 [Contig_View]  SESN1 [Vega]
ICGC DataPortalENSG00000080546
TCGA cBioPortalSESN1
AceView (NCBI)SESN1
Genatlas (Paris)SESN1
WikiGenes27244
SOURCE (Princeton)SESN1
Genetics Home Reference (NIH)SESN1
Genomic and cartography
GoldenPath hg38 (UCSC)SESN1  -     chr6:108986437-109094505 -  6q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SESN1  -     6q21   [Description]    (hg19-Feb_2009)
EnsemblSESN1 - 6q21 [CytoView hg19]  SESN1 - 6q21 [CytoView hg38]
Mapping of homologs : NCBISESN1 [Mapview hg19]  SESN1 [Mapview hg38]
OMIM606103   
Gene and transcription
Genbank (Entrez)AF033120 AF033121 AF033122 AJ420599 AK001886
RefSeq transcript (Entrez)NM_001199933 NM_001199934 NM_014454
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SESN1
Cluster EST : UnigeneHs.591336 [ NCBI ]
CGAP (NCI)Hs.591336
Alternative Splicing GalleryENSG00000080546
Gene ExpressionSESN1 [ NCBI-GEO ]   SESN1 [ EBI - ARRAY_EXPRESS ]   SESN1 [ SEEK ]   SESN1 [ MEM ]
Gene Expression Viewer (FireBrowse)SESN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27244
GTEX Portal (Tissue expression)SESN1
Human Protein AtlasENSG00000080546-SESN1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6P5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6P5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6P5
Splice isoforms : SwissVarQ9Y6P5
PhosPhoSitePlusQ9Y6P5
Domains : Interpro (EBI)AhpD-like    Sestrin   
Domain families : Pfam (Sanger)PA26 (PF04636)   
Domain families : Pfam (NCBI)pfam04636   
Conserved Domain (NCBI)SESN1
DMDM Disease mutations27244
Blocks (Seattle)SESN1
SuperfamilyQ9Y6P5
Human Protein Atlas [tissue]ENSG00000080546-SESN1 [tissue]
Peptide AtlasQ9Y6P5
HPRD07310
IPIIPI00002536   IPI00216155   IPI00216156   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6P5
IntAct (EBI)Q9Y6P5
FunCoupENSG00000080546
BioGRIDSESN1
STRING (EMBL)SESN1
ZODIACSESN1
Ontologies - Pathways
QuickGOQ9Y6P5
Ontology : AmiGOfibrillar center  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  positive regulation of macroautophagy  oxidoreductase activity, acting on peroxide as acceptor  TORC2 complex  cellular response to amino acid starvation  cellular response to glucose starvation  peroxiredoxin activity  oxidation-reduction process  GATOR2 complex  GATOR2 complex  leucine binding  leucine binding  cellular response to amino acid stimulus  cellular response to leucine  reactive oxygen species metabolic process  cellular oxidant detoxification  regulation of response to reactive oxygen species  negative regulation of TORC1 signaling  negative regulation of TORC1 signaling  cellular response to leucine starvation  
Ontology : EGO-EBIfibrillar center  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  positive regulation of macroautophagy  oxidoreductase activity, acting on peroxide as acceptor  TORC2 complex  cellular response to amino acid starvation  cellular response to glucose starvation  peroxiredoxin activity  oxidation-reduction process  GATOR2 complex  GATOR2 complex  leucine binding  leucine binding  cellular response to amino acid stimulus  cellular response to leucine  reactive oxygen species metabolic process  cellular oxidant detoxification  regulation of response to reactive oxygen species  negative regulation of TORC1 signaling  negative regulation of TORC1 signaling  cellular response to leucine starvation  
Pathways : KEGGp53 signaling pathway   
NDEx NetworkSESN1
Atlas of Cancer Signalling NetworkSESN1
Wikipedia pathwaysSESN1
Orthology - Evolution
OrthoDB27244
GeneTree (enSembl)ENSG00000080546
Phylogenetic Trees/Animal Genes : TreeFamSESN1
HOVERGENQ9Y6P5
HOGENOMQ9Y6P5
Homologs : HomoloGeneSESN1
Homology/Alignments : Family Browser (UCSC)SESN1
Gene fusions - Rearrangements
Fusion : MitelmanSESN1/ECHDC1 [6q21/6q22.33]  
Fusion : MitelmanSESN1/MGST2 [6q21/4q31.1]  [t(4;6)(q31;q21)]  
Fusion PortalSESN1 6q21 AIM1 6q21 BRCA
Fusion PortalSESN1 6q21 ECHDC1 6q22.33 LUAD
Fusion PortalSESN1 6q21 EYS 6q12 LUSC
Fusion : QuiverSESN1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSESN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SESN1
dbVarSESN1
ClinVarSESN1
1000_GenomesSESN1 
Exome Variant ServerSESN1
ExAC (Exome Aggregation Consortium)ENSG00000080546
GNOMAD BrowserENSG00000080546
Varsome BrowserSESN1
Genetic variants : HAPMAP27244
Genomic Variants (DGV)SESN1 [DGVbeta]
DECIPHERSESN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSESN1 
Mutations
ICGC Data PortalSESN1 
TCGA Data PortalSESN1 
Broad Tumor PortalSESN1
OASIS PortalSESN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSESN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSESN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SESN1
DgiDB (Drug Gene Interaction Database)SESN1
DoCM (Curated mutations)SESN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SESN1 (select a term)
intoGenSESN1
Cancer3DSESN1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606103   
Orphanet
DisGeNETSESN1
MedgenSESN1
Genetic Testing Registry SESN1
NextProtQ9Y6P5 [Medical]
TSGene27244
GENETestsSESN1
Target ValidationSESN1
Huge Navigator SESN1 [HugePedia]
snp3D : Map Gene to Disease27244
BioCentury BCIQSESN1
ClinGenSESN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27244
Chemical/Pharm GKB GenePA134927596
Clinical trialSESN1
Miscellaneous
canSAR (ICR)SESN1 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSESN1
EVEXSESN1
GoPubMedSESN1
iHOPSESN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:38:27 CET 2018

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