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SESN1 (sestrin 1)

Identity

Alias (NCBI)PA26
SEST1
HGNC (Hugo) SESN1
HGNC Alias symbSEST1
PA26
LocusID (NCBI) 27244
Atlas_Id 42271
Location 6q21  [Link to chromosome band 6q21]
Location_base_pair Starts at 108984309 and ends at 109094846 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GPATCH8 (17q21.31)::SESN1 (6q21)SESN1 (6q21)::AIM1 (6q21)SESN1 (6q21)::ECHDC1 (6q22.33)
SESN1 (6q21)::EYS (6q12)SESN1 (6q21)::MGST2 (4q31.1)SESN1 (6q21)::SESN1 (6q21)
SESN1 6q21::AIM1 6q21SESN1 6q21::ECHDC1 6q22.33SESN1 6q21::EYS 6q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;9)(p22;q34) DEK::NUP214 in Childhood


External links

 

Nomenclature
HGNC (Hugo)SESN1   21595
Cards
Entrez_Gene (NCBI)SESN1    sestrin 1
AliasesPA26; SEST1
GeneCards (Weizmann)SESN1
Ensembl hg19 (Hinxton)ENSG00000080546 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000080546 [Gene_View]  ENSG00000080546 [Sequence]  chr6:108984309-109094846 [Contig_View]  SESN1 [Vega]
ICGC DataPortalENSG00000080546
TCGA cBioPortalSESN1
AceView (NCBI)SESN1
Genatlas (Paris)SESN1
SOURCE (Princeton)SESN1
Genetics Home Reference (NIH)SESN1
Genomic and cartography
GoldenPath hg38 (UCSC)SESN1  -     chr6:108984309-109094846 -  6q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SESN1  -     6q21   [Description]    (hg19-Feb_2009)
GoldenPathSESN1 - 6q21 [CytoView hg19]  SESN1 - 6q21 [CytoView hg38]
ImmunoBaseENSG00000080546
Genome Data Viewer NCBISESN1 [Mapview hg19]  
OMIM606103   
Gene and transcription
Genbank (Entrez)AF033120 AF033121 AF033122 AJ420599 AK001886
RefSeq transcript (Entrez)NM_001199933 NM_001199934 NM_014454
Consensus coding sequences : CCDS (NCBI)SESN1
Gene ExpressionSESN1 [ NCBI-GEO ]   SESN1 [ EBI - ARRAY_EXPRESS ]   SESN1 [ SEEK ]   SESN1 [ MEM ]
Gene Expression Viewer (FireBrowse)SESN1 [ Firebrowse - Broad ]
GenevisibleExpression of SESN1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27244
GTEX Portal (Tissue expression)SESN1
Human Protein AtlasENSG00000080546-SESN1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6P5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6P5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6P5
PhosPhoSitePlusQ9Y6P5
Domains : Interpro (EBI)AhpD-like    Sestrin   
Domain families : Pfam (Sanger)PA26 (PF04636)   
Domain families : Pfam (NCBI)pfam04636   
Conserved Domain (NCBI)SESN1
SuperfamilyQ9Y6P5
AlphaFold pdb e-kbQ9Y6P5   
Human Protein Atlas [tissue]ENSG00000080546-SESN1 [tissue]
HPRD07310
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6P5
IntAct (EBI)Q9Y6P5
BioGRIDSESN1
STRING (EMBL)SESN1
ZODIACSESN1
Ontologies - Pathways
QuickGOQ9Y6P5
Ontology : AmiGOfibrillar center  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  positive regulation of macroautophagy  oxidoreductase activity, acting on peroxide as acceptor  cellular response to amino acid starvation  cellular response to glucose starvation  leucine binding  leucine binding  cellular response to leucine  reactive oxygen species metabolic process  cellular oxidant detoxification  regulation of response to reactive oxygen species  negative regulation of TORC1 signaling  negative regulation of TORC1 signaling  cellular response to leucine starvation  
Ontology : EGO-EBIfibrillar center  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  positive regulation of macroautophagy  oxidoreductase activity, acting on peroxide as acceptor  cellular response to amino acid starvation  cellular response to glucose starvation  leucine binding  leucine binding  cellular response to leucine  reactive oxygen species metabolic process  cellular oxidant detoxification  regulation of response to reactive oxygen species  negative regulation of TORC1 signaling  negative regulation of TORC1 signaling  cellular response to leucine starvation  
Pathways : KEGGKEGG_P53_SIGNALING   
NDEx NetworkSESN1
Atlas of Cancer Signalling NetworkSESN1
Wikipedia pathwaysSESN1
Orthology - Evolution
OrthoDB27244
GeneTree (enSembl)ENSG00000080546
Phylogenetic Trees/Animal Genes : TreeFamSESN1
Homologs : HomoloGeneSESN1
Homology/Alignments : Family Browser (UCSC)SESN1
Gene fusions - Rearrangements
Fusion : MitelmanSESN1::ECHDC1 [6q21/6q22.33]  
Fusion : MitelmanSESN1::MGST2 [6q21/4q31.1]  
Fusion : QuiverSESN1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSESN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SESN1
dbVarSESN1
ClinVarSESN1
MonarchSESN1
1000_GenomesSESN1 
Exome Variant ServerSESN1
GNOMAD BrowserENSG00000080546
Varsome BrowserSESN1
ACMGSESN1 variants
VarityQ9Y6P5
Genomic Variants (DGV)SESN1 [DGVbeta]
DECIPHERSESN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSESN1 
Mutations
ICGC Data PortalSESN1 
TCGA Data PortalSESN1 
Broad Tumor PortalSESN1
OASIS PortalSESN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSESN1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSESN1
Mutations and Diseases : HGMDSESN1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSESN1
DgiDB (Drug Gene Interaction Database)SESN1
DoCM (Curated mutations)SESN1
CIViC (Clinical Interpretations of Variants in Cancer)SESN1
Cancer3DSESN1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606103   
Orphanet
DisGeNETSESN1
MedgenSESN1
Genetic Testing Registry SESN1
NextProtQ9Y6P5 [Medical]
GENETestsSESN1
Target ValidationSESN1
Huge Navigator SESN1 [HugePedia]
ClinGenSESN1
Clinical trials, drugs, therapy
MyCancerGenomeSESN1
Protein Interactions : CTDSESN1
Pharm GKB GenePA134927596
PharosQ9Y6P5
Clinical trialSESN1
Miscellaneous
canSAR (ICR)SESN1
HarmonizomeSESN1
ARCHS4SESN1
DataMed IndexSESN1
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSESN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:58:08 CET 2022

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