Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SESN2 (sestrin 2)

Identity

Alias_symbol (synonym)SES2
DKFZp761M0212
HI95
SEST2
Other alias
HGNC (Hugo) SESN2
LocusID (NCBI) 83667
Atlas_Id 47453
Location 1p35.3  [Link to chromosome band 1p35]
Location_base_pair Starts at 28259452 and ends at 28282491 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		RRAGA (9p22.1) / SESN2 (1p35.3)SESN2 (1p35.3) / SESN2 (1p35.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SESN2   20746
Cards
Entrez_Gene (NCBI)SESN2  83667  sestrin 2
AliasesHI95; SES2; SEST2
GeneCards (Weizmann)SESN2
Ensembl hg19 (Hinxton)ENSG00000130766 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130766 [Gene_View]  chr1:28259452-28282491 [Contig_View]  SESN2 [Vega]
ICGC DataPortalENSG00000130766
TCGA cBioPortalSESN2
AceView (NCBI)SESN2
Genatlas (Paris)SESN2
WikiGenes83667
SOURCE (Princeton)SESN2
Genetics Home Reference (NIH)SESN2
Genomic and cartography
GoldenPath hg38 (UCSC)SESN2  -     chr1:28259452-28282491 +  1p35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SESN2  -     1p35.3   [Description]    (hg19-Feb_2009)
EnsemblSESN2 - 1p35.3 [CytoView hg19]  SESN2 - 1p35.3 [CytoView hg38]
Mapping of homologs : NCBISESN2 [Mapview hg19]  SESN2 [Mapview hg38]
OMIM607767   
Gene and transcription
Genbank (Entrez)AK025640 AK027896 AK315710 AL136551 AY123223
RefSeq transcript (Entrez)NM_031459
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SESN2
Cluster EST : UnigeneHs.469543 [ NCBI ]
CGAP (NCI)Hs.469543
Alternative Splicing GalleryENSG00000130766
Gene ExpressionSESN2 [ NCBI-GEO ]   SESN2 [ EBI - ARRAY_EXPRESS ]   SESN2 [ SEEK ]   SESN2 [ MEM ]
Gene Expression Viewer (FireBrowse)SESN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83667
GTEX Portal (Tissue expression)SESN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP58004   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP58004  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP58004
Splice isoforms : SwissVarP58004
PhosPhoSitePlusP58004
Domains : Interpro (EBI)AhpD-like    Sestrin   
Domain families : Pfam (Sanger)PA26 (PF04636)   
Domain families : Pfam (NCBI)pfam04636   
Conserved Domain (NCBI)SESN2
DMDM Disease mutations83667
Blocks (Seattle)SESN2
PDB (SRS)5CUF    5DJ4    5T0N   
PDB (PDBSum)5CUF    5DJ4    5T0N   
PDB (IMB)5CUF    5DJ4    5T0N   
PDB (RSDB)5CUF    5DJ4    5T0N   
Structural Biology KnowledgeBase5CUF    5DJ4    5T0N   
SCOP (Structural Classification of Proteins)5CUF    5DJ4    5T0N   
CATH (Classification of proteins structures)5CUF    5DJ4    5T0N   
SuperfamilyP58004
Human Protein AtlasENSG00000130766
Peptide AtlasP58004
HPRD06378
IPIIPI00010539   
Protein Interaction databases
DIP (DOE-UCLA)P58004
IntAct (EBI)P58004
FunCoupENSG00000130766
BioGRIDSESN2
STRING (EMBL)SESN2
ZODIACSESN2
Ontologies - Pathways
QuickGOP58004
Ontology : AmiGOregulation of protein phosphorylation  GDP-dissociation inhibitor activity  protein binding  nucleus  cytoplasm  mitochondrion  cytosol  fatty acid beta-oxidation  response to glucose  positive regulation of macroautophagy  oxidoreductase activity, acting on peroxide as acceptor  negative regulation of cell growth  DNA damage response, signal transduction by p53 class mediator  nucleotide-activated protein kinase complex  TORC2 complex  mitochondrial DNA metabolic process  sulfiredoxin activity  sulfiredoxin activity  response to insulin  cellular response to amino acid starvation  cellular response to oxidative stress  positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress  cellular response to glucose starvation  protein kinase B signaling  glucose import  GATOR2 complex  triglyceride homeostasis  leucine binding  cellular response to amino acid stimulus  cellular response to leucine  reactive oxygen species metabolic process  regulation of gluconeogenesis involved in cellular glucose homeostasis  cellular oxidant detoxification  cellular oxidant detoxification  cellular oxidant detoxification  positive regulation of protein localization to nucleus  regulation of response to reactive oxygen species  negative regulation of translation in response to endoplasmic reticulum stress  negative regulation of TORC1 signaling  positive regulation of lipophagy  cellular response to leucine starvation  ATG1/ULK1 kinase complex  regulation of cAMP-dependent protein kinase activity  
Ontology : EGO-EBIregulation of protein phosphorylation  GDP-dissociation inhibitor activity  protein binding  nucleus  cytoplasm  mitochondrion  cytosol  fatty acid beta-oxidation  response to glucose  positive regulation of macroautophagy  oxidoreductase activity, acting on peroxide as acceptor  negative regulation of cell growth  DNA damage response, signal transduction by p53 class mediator  nucleotide-activated protein kinase complex  TORC2 complex  mitochondrial DNA metabolic process  sulfiredoxin activity  sulfiredoxin activity  response to insulin  cellular response to amino acid starvation  cellular response to oxidative stress  positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress  cellular response to glucose starvation  protein kinase B signaling  glucose import  GATOR2 complex  triglyceride homeostasis  leucine binding  cellular response to amino acid stimulus  cellular response to leucine  reactive oxygen species metabolic process  regulation of gluconeogenesis involved in cellular glucose homeostasis  cellular oxidant detoxification  cellular oxidant detoxification  cellular oxidant detoxification  positive regulation of protein localization to nucleus  regulation of response to reactive oxygen species  negative regulation of translation in response to endoplasmic reticulum stress  negative regulation of TORC1 signaling  positive regulation of lipophagy  cellular response to leucine starvation  ATG1/ULK1 kinase complex  regulation of cAMP-dependent protein kinase activity  
Pathways : KEGGp53 signaling pathway   
NDEx NetworkSESN2
Atlas of Cancer Signalling NetworkSESN2
Wikipedia pathwaysSESN2
Orthology - Evolution
OrthoDB83667
GeneTree (enSembl)ENSG00000130766
Phylogenetic Trees/Animal Genes : TreeFamSESN2
HOVERGENP58004
HOGENOMP58004
Homologs : HomoloGeneSESN2
Homology/Alignments : Family Browser (UCSC)SESN2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSESN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SESN2
dbVarSESN2
ClinVarSESN2
1000_GenomesSESN2 
Exome Variant ServerSESN2
ExAC (Exome Aggregation Consortium)SESN2 (select the gene name)
Genetic variants : HAPMAP83667
Genomic Variants (DGV)SESN2 [DGVbeta]
DECIPHERSESN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSESN2 
Mutations
ICGC Data PortalSESN2 
TCGA Data PortalSESN2 
Broad Tumor PortalSESN2
OASIS PortalSESN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSESN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSESN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SESN2
DgiDB (Drug Gene Interaction Database)SESN2
DoCM (Curated mutations)SESN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SESN2 (select a term)
intoGenSESN2
Cancer3DSESN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607767   
Orphanet
MedgenSESN2
Genetic Testing Registry SESN2
NextProtP58004 [Medical]
TSGene83667
GENETestsSESN2
Target ValidationSESN2
Huge Navigator SESN2 [HugePedia]
snp3D : Map Gene to Disease83667
BioCentury BCIQSESN2
ClinGenSESN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83667
Chemical/Pharm GKB GenePA134882791
Clinical trialSESN2
Miscellaneous
canSAR (ICR)SESN2 (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSESN2
EVEXSESN2
GoPubMedSESN2
iHOPSESN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:55:04 CEST 2017
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