| Nomenclature |
|---|
| HGNC (Hugo) | SESN2 20746 |
| Cards |
|---|
| Entrez_Gene (NCBI) | SESN2 83667 sestrin 2 |
| Aliases | HI95; SES2; SEST2 |
| GeneCards (Weizmann) | SESN2 |
| Ensembl hg19 (Hinxton) | ENSG00000130766 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000130766 [Gene_View] ENSG00000130766 [Sequence] chr1:28259452-28282491 [Contig_View] SESN2 [Vega] |
| ICGC DataPortal | ENSG00000130766 |
| TCGA cBioPortal | SESN2 |
| AceView (NCBI) | SESN2 |
| Genatlas (Paris) | SESN2 |
| WikiGenes | 83667 |
| SOURCE (Princeton) | SESN2 |
| Genetics Home Reference (NIH) | SESN2 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | SESN2 - chr1:28259452-28282491 + 1p35.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | SESN2 - 1p35.3 [Description] (hg19-Feb_2009) |
| Ensembl | SESN2 - 1p35.3 [CytoView hg19] SESN2 - 1p35.3 [CytoView hg38] |
| Mapping of homologs : NCBI | SESN2 [Mapview hg19] SESN2 [Mapview hg38] |
| OMIM | 607767 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK025640 AK027896 AK315710 AL136551 AY123223 |
| RefSeq transcript (Entrez) | NM_031459 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | SESN2 |
| Cluster EST : Unigene | Hs.469543 [ NCBI ] |
| CGAP (NCI) | Hs.469543 |
| Alternative Splicing Gallery | ENSG00000130766 |
| Gene Expression | SESN2 [ NCBI-GEO ] SESN2 [ EBI - ARRAY_EXPRESS ]
SESN2 [ SEEK ] SESN2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | SESN2 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 83667 |
| GTEX Portal (Tissue expression) | SESN2 |
| Human Protein Atlas | ENSG00000130766-SESN2 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P58004 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P58004 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P58004 |
| Splice isoforms : SwissVar | P58004 |
| PhosPhoSitePlus | P58004 |
| Domains : Interpro (EBI) | AhpD-like Sestrin |
| Domain families : Pfam (Sanger) | PA26 (PF04636) |
| Domain families : Pfam (NCBI) | pfam04636 |
| Conserved Domain (NCBI) | SESN2 |
| DMDM Disease mutations | 83667 |
| Blocks (Seattle) | SESN2 |
| PDB (SRS) | 5CUF 5DJ4 5T0N |
| PDB (PDBSum) | 5CUF 5DJ4 5T0N |
| PDB (IMB) | 5CUF 5DJ4 5T0N |
| PDB (RSDB) | 5CUF 5DJ4 5T0N |
| Structural Biology KnowledgeBase | 5CUF 5DJ4 5T0N |
| SCOP (Structural Classification of Proteins) | 5CUF 5DJ4 5T0N |
| CATH (Classification of proteins structures) | 5CUF 5DJ4 5T0N |
| Superfamily | P58004 |
| Human Protein Atlas [tissue] | ENSG00000130766-SESN2 [tissue] |
| Peptide Atlas | P58004 |
| HPRD | 06378 |
| IPI | IPI00010539 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P58004 |
| IntAct (EBI) | P58004 |
| FunCoup | ENSG00000130766 |
| BioGRID | SESN2 |
| STRING (EMBL) | SESN2 |
| ZODIAC | SESN2 |
| Ontologies - Pathways |
|---|
| QuickGO | P58004 |
| Ontology : AmiGO | regulation of protein phosphorylation GDP-dissociation inhibitor activity protein binding nucleus cytoplasm cytoplasm mitochondrion cytosol regulation of gluconeogenesis fatty acid beta-oxidation response to glucose positive regulation of macroautophagy positive regulation of macroautophagy oxidoreductase activity, acting on peroxide as acceptor oxidoreductase activity, acting on peroxide as acceptor negative regulation of cell growth DNA damage response, signal transduction by p53 class mediator nucleotide-activated protein kinase complex TORC2 complex TORC2 complex mitochondrial DNA metabolic process sulfiredoxin activity sulfiredoxin activity response to insulin cellular response to amino acid starvation cellular response to oxidative stress positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress cellular response to glucose starvation glucose homeostasis protein kinase B signaling glucose import GATOR2 complex GATOR2 complex triglyceride homeostasis leucine binding leucine binding cellular response to amino acid stimulus cellular response to amino acid stimulus cellular response to leucine cellular response to leucine reactive oxygen species metabolic process cellular oxidant detoxification cellular oxidant detoxification cellular oxidant detoxification positive regulation of protein localization to nucleus regulation of response to reactive oxygen species negative regulation of translation in response to endoplasmic reticulum stress negative regulation of TORC1 signaling negative regulation of TORC1 signaling positive regulation of lipophagy cellular response to leucine starvation cellular response to leucine starvation Atg1/ULK1 kinase complex regulation of cAMP-dependent protein kinase activity |
| Ontology : EGO-EBI | regulation of protein phosphorylation GDP-dissociation inhibitor activity protein binding nucleus cytoplasm cytoplasm mitochondrion cytosol regulation of gluconeogenesis fatty acid beta-oxidation response to glucose positive regulation of macroautophagy positive regulation of macroautophagy oxidoreductase activity, acting on peroxide as acceptor oxidoreductase activity, acting on peroxide as acceptor negative regulation of cell growth DNA damage response, signal transduction by p53 class mediator nucleotide-activated protein kinase complex TORC2 complex TORC2 complex mitochondrial DNA metabolic process sulfiredoxin activity sulfiredoxin activity response to insulin cellular response to amino acid starvation cellular response to oxidative stress positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress cellular response to glucose starvation glucose homeostasis protein kinase B signaling glucose import GATOR2 complex GATOR2 complex triglyceride homeostasis leucine binding leucine binding cellular response to amino acid stimulus cellular response to amino acid stimulus cellular response to leucine cellular response to leucine reactive oxygen species metabolic process cellular oxidant detoxification cellular oxidant detoxification cellular oxidant detoxification positive regulation of protein localization to nucleus regulation of response to reactive oxygen species negative regulation of translation in response to endoplasmic reticulum stress negative regulation of TORC1 signaling negative regulation of TORC1 signaling positive regulation of lipophagy cellular response to leucine starvation cellular response to leucine starvation Atg1/ULK1 kinase complex regulation of cAMP-dependent protein kinase activity |
| Pathways : KEGG | p53 signaling pathway |
| NDEx Network | SESN2 |
| Atlas of Cancer Signalling Network | SESN2 |
| Wikipedia pathways | SESN2 |
| Orthology - Evolution |
|---|
| OrthoDB | 83667 |
| GeneTree (enSembl) | ENSG00000130766 |
| Phylogenetic Trees/Animal Genes : TreeFam | SESN2 |
| HOVERGEN | P58004 |
| HOGENOM | P58004 |
| Homologs : HomoloGene | SESN2 |
| Homology/Alignments : Family Browser (UCSC) | SESN2 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | SESN2 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | SESN2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | SESN2 |
| dbVar | SESN2 |
| ClinVar | SESN2 |
| 1000_Genomes | SESN2 |
| Exome Variant Server | SESN2 |
| ExAC (Exome Aggregation Consortium) | ENSG00000130766 |
| GNOMAD Browser | ENSG00000130766 |
| Varsome Browser | SESN2 |
| Genetic variants : HAPMAP | 83667 |
| Genomic Variants (DGV) | SESN2 [DGVbeta] |
| DECIPHER | SESN2 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | SESN2 |
| Mutations |
|---|
| ICGC Data Portal | SESN2 |
| TCGA Data Portal | SESN2 |
| Broad Tumor Portal | SESN2 |
| OASIS Portal | SESN2 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | SESN2 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | SESN2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search SESN2 |
| DgiDB (Drug Gene Interaction Database) | SESN2 |
| DoCM (Curated mutations) | SESN2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | SESN2 (select a term) |
| intoGen | SESN2 |
| Cancer3D | SESN2(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 607767 |
| Orphanet | |
| DisGeNET | SESN2 |
| Medgen | SESN2 |
| Genetic Testing Registry | SESN2
|
| NextProt | P58004 [Medical] |
| TSGene | 83667 |
| GENETests | SESN2 |
| Target Validation | SESN2 |
| Huge Navigator |
SESN2 [HugePedia] |
| snp3D : Map Gene to Disease | 83667 |
| BioCentury BCIQ | SESN2 |
| ClinGen | SESN2 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 83667 |
| Chemical/Pharm GKB Gene | PA134882791 |
| Clinical trial | SESN2 |
| Miscellaneous |
|---|
| canSAR (ICR) | SESN2 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 67 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | SESN2 |
| EVEX | SESN2 |
| GoPubMed | SESN2 |
| iHOP | SESN2 |
