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SESN3 (sestrin 3)

Identity

Alias (NCBI)SEST3
HGNC (Hugo) SESN3
HGNC Alias symbSEST3
MGC29667
LocusID (NCBI) 143686
Atlas_Id 56562
Location 11q21  [Link to chromosome band 11q21]
Location_base_pair Starts at 95165513 and ends at 95231202 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SESN3   23060
Cards
Entrez_Gene (NCBI)SESN3    sestrin 3
AliasesSEST3
GeneCards (Weizmann)SESN3
Ensembl hg19 (Hinxton)ENSG00000149212 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149212 [Gene_View]  ENSG00000149212 [Sequence]  chr11:95165513-95231202 [Contig_View]  SESN3 [Vega]
ICGC DataPortalENSG00000149212
TCGA cBioPortalSESN3
AceView (NCBI)SESN3
Genatlas (Paris)SESN3
SOURCE (Princeton)SESN3
Genetics Home Reference (NIH)SESN3
Genomic and cartography
GoldenPath hg38 (UCSC)SESN3  -     chr11:95165513-95231202 -  11q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SESN3  -     11q21   [Description]    (hg19-Feb_2009)
GoldenPathSESN3 - 11q21 [CytoView hg19]  SESN3 - 11q21 [CytoView hg38]
ImmunoBaseENSG00000149212
Genome Data Viewer NCBISESN3 [Mapview hg19]  
OMIM607768   
Gene and transcription
Genbank (Entrez)AB072894 AF086251 AF086504 AK091132 AK096300
RefSeq transcript (Entrez)NM_001271594 NM_144665
Consensus coding sequences : CCDS (NCBI)SESN3
Gene ExpressionSESN3 [ NCBI-GEO ]   SESN3 [ EBI - ARRAY_EXPRESS ]   SESN3 [ SEEK ]   SESN3 [ MEM ]
Gene Expression Viewer (FireBrowse)SESN3 [ Firebrowse - Broad ]
GenevisibleExpression of SESN3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)143686
GTEX Portal (Tissue expression)SESN3
Human Protein AtlasENSG00000149212-SESN3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP58005   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP58005  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP58005
PhosPhoSitePlusP58005
Domains : Interpro (EBI)AhpD-like    Sestrin   
Domain families : Pfam (Sanger)PA26 (PF04636)   
Domain families : Pfam (NCBI)pfam04636   
Conserved Domain (NCBI)SESN3
SuperfamilyP58005
AlphaFold pdb e-kbP58005   
Human Protein Atlas [tissue]ENSG00000149212-SESN3 [tissue]
HPRD09682
Protein Interaction databases
DIP (DOE-UCLA)P58005
IntAct (EBI)P58005
BioGRIDSESN3
STRING (EMBL)SESN3
ZODIACSESN3
Ontologies - Pathways
QuickGOP58005
Ontology : AmiGOprotein binding  nucleus  cytoplasm  positive regulation of macroautophagy  oxidoreductase activity, acting on peroxide as acceptor  TORC2 complex  response to insulin  cellular response to amino acid starvation  TORC2 signaling  cellular response to glucose starvation  glucose homeostasis  regulation of insulin receptor signaling pathway  regulation of protein kinase B signaling  leucine binding  cellular response to leucine  regulation of response to reactive oxygen species  negative regulation of TORC1 signaling  negative regulation of TORC1 signaling  cellular response to leucine starvation  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  positive regulation of macroautophagy  oxidoreductase activity, acting on peroxide as acceptor  TORC2 complex  response to insulin  cellular response to amino acid starvation  TORC2 signaling  cellular response to glucose starvation  glucose homeostasis  regulation of insulin receptor signaling pathway  regulation of protein kinase B signaling  leucine binding  cellular response to leucine  regulation of response to reactive oxygen species  negative regulation of TORC1 signaling  negative regulation of TORC1 signaling  cellular response to leucine starvation  
Pathways : KEGGp53 signaling pathway   
NDEx NetworkSESN3
Atlas of Cancer Signalling NetworkSESN3
Wikipedia pathwaysSESN3
Orthology - Evolution
OrthoDB143686
GeneTree (enSembl)ENSG00000149212
Phylogenetic Trees/Animal Genes : TreeFamSESN3
Homologs : HomoloGeneSESN3
Homology/Alignments : Family Browser (UCSC)SESN3
Gene fusions - Rearrangements
Fusion : QuiverSESN3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSESN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SESN3
dbVarSESN3
ClinVarSESN3
MonarchSESN3
1000_GenomesSESN3 
Exome Variant ServerSESN3
GNOMAD BrowserENSG00000149212
Varsome BrowserSESN3
ACMGSESN3 variants
VarityP58005
Genomic Variants (DGV)SESN3 [DGVbeta]
DECIPHERSESN3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSESN3 
Mutations
ICGC Data PortalSESN3 
TCGA Data PortalSESN3 
Broad Tumor PortalSESN3
OASIS PortalSESN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSESN3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSESN3
Mutations and Diseases : HGMDSESN3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSESN3
DgiDB (Drug Gene Interaction Database)SESN3
DoCM (Curated mutations)SESN3
CIViC (Clinical Interpretations of Variants in Cancer)SESN3
Cancer3DSESN3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607768   
Orphanet
DisGeNETSESN3
MedgenSESN3
Genetic Testing Registry SESN3
NextProtP58005 [Medical]
GENETestsSESN3
Target ValidationSESN3
Huge Navigator SESN3 [HugePedia]
ClinGenSESN3
Clinical trials, drugs, therapy
MyCancerGenomeSESN3
Protein Interactions : CTDSESN3
Pharm GKB GenePA134914983
PharosP58005
Clinical trialSESN3
Miscellaneous
canSAR (ICR)SESN3
HarmonizomeSESN3
DataMed IndexSESN3
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSESN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:30:45 CEST 2021

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