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SETD4 (SET domain containing 4)

Identity

Alias (NCBI)C21orf18
C21orf27
HGNC (Hugo) SETD4
HGNC Previous nameC21orf27
 C21orf18
HGNC Previous namechromosome 21 open reading frame 27
 chromosome 21 open reading frame 18
LocusID (NCBI) 54093
Atlas_Id 73155
Location 21q22.12  [Link to chromosome band 21q22]
Location_base_pair Starts at 36034541 and ends at 36060526 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALB (4q13.3) / SETD4 (21q22.12)HDGFRP2 (19p13.3) / SETD4 (21q22.12)SETD4 (21q22.12) / ANKRD17 (4q13.3)
SETD4 (21q22.12) / B4GALT6 (18q12.1)SETD4 (21q22.12) / FTCD (21q22.3)SETD4 FTCD
SETD4 B4GALT6

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SETD4   1258
Cards
Entrez_Gene (NCBI)SETD4    SET domain containing 4
AliasesC21orf18; C21orf27
GeneCards (Weizmann)SETD4
Ensembl hg19 (Hinxton)ENSG00000185917 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185917 [Gene_View]  ENSG00000185917 [Sequence]  chr21:36034541-36060526 [Contig_View]  SETD4 [Vega]
ICGC DataPortalENSG00000185917
TCGA cBioPortalSETD4
AceView (NCBI)SETD4
Genatlas (Paris)SETD4
SOURCE (Princeton)SETD4
Genetics Home Reference (NIH)SETD4
Genomic and cartography
GoldenPath hg38 (UCSC)SETD4  -     chr21:36034541-36060526 -  21q22.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SETD4  -     21q22.12   [Description]    (hg19-Feb_2009)
GoldenPathSETD4 - 21q22.12 [CytoView hg19]  SETD4 - 21q22.12 [CytoView hg38]
ImmunoBaseENSG00000185917
Genome Data Viewer NCBISETD4 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AB004848 AB004849 AB004852 AB004853 AF391112
RefSeq transcript (Entrez)NM_001007258 NM_001007259 NM_001007260 NM_001007261 NM_001007262 NM_001286752 NM_017438
Consensus coding sequences : CCDS (NCBI)SETD4
Gene ExpressionSETD4 [ NCBI-GEO ]   SETD4 [ EBI - ARRAY_EXPRESS ]   SETD4 [ SEEK ]   SETD4 [ MEM ]
Gene Expression Viewer (FireBrowse)SETD4 [ Firebrowse - Broad ]
GenevisibleExpression of SETD4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54093
GTEX Portal (Tissue expression)SETD4
Human Protein AtlasENSG00000185917-SETD4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NVD3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NVD3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NVD3
PhosPhoSitePlusQ9NVD3
Domaine pattern : Prosite (Expaxy)SET (PS50280)   
Domains : Interpro (EBI)Rubisco_LSMT_subst-bd    Rubisco_LSMT_subst-bd_sf    SET_dom    SET_MeTrfase   
Domain families : Pfam (Sanger)Rubis-subs-bind (PF09273)    SET (PF00856)   
Domain families : Pfam (NCBI)pfam09273    pfam00856   
Conserved Domain (NCBI)SETD4
SuperfamilyQ9NVD3
AlphaFold pdb e-kbQ9NVD3   
Human Protein Atlas [tissue]ENSG00000185917-SETD4 [tissue]
HPRD10743
Protein Interaction databases
DIP (DOE-UCLA)Q9NVD3
IntAct (EBI)Q9NVD3
BioGRIDSETD4
STRING (EMBL)SETD4
ZODIACSETD4
Ontologies - Pathways
QuickGOQ9NVD3
Ontology : AmiGOnucleus  cytosol  protein-lysine N-methyltransferase activity  peptidyl-lysine trimethylation  peptidyl-lysine monomethylation  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  histone H4-K20 trimethylation  histone methyltransferase activity (H4-K20 specific)  histone methyltransferase activity (H3-K4 specific)  histone H3-K4 dimethylation  positive regulation of inflammatory response  regulation of cell proliferation in bone marrow  histone H3-K4 monomethylation  
Ontology : EGO-EBInucleus  cytosol  protein-lysine N-methyltransferase activity  peptidyl-lysine trimethylation  peptidyl-lysine monomethylation  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  histone H4-K20 trimethylation  histone methyltransferase activity (H4-K20 specific)  histone methyltransferase activity (H3-K4 specific)  histone H3-K4 dimethylation  positive regulation of inflammatory response  regulation of cell proliferation in bone marrow  histone H3-K4 monomethylation  
NDEx NetworkSETD4
Atlas of Cancer Signalling NetworkSETD4
Wikipedia pathwaysSETD4
Orthology - Evolution
OrthoDB54093
GeneTree (enSembl)ENSG00000185917
Phylogenetic Trees/Animal Genes : TreeFamSETD4
Homologs : HomoloGeneSETD4
Homology/Alignments : Family Browser (UCSC)SETD4
Gene fusions - Rearrangements
Fusion : QuiverSETD4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSETD4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SETD4
dbVarSETD4
ClinVarSETD4
MonarchSETD4
1000_GenomesSETD4 
Exome Variant ServerSETD4
GNOMAD BrowserENSG00000185917
Varsome BrowserSETD4
ACMGSETD4 variants
VarityQ9NVD3
Genomic Variants (DGV)SETD4 [DGVbeta]
DECIPHERSETD4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSETD4 
Mutations
ICGC Data PortalSETD4 
TCGA Data PortalSETD4 
Broad Tumor PortalSETD4
OASIS PortalSETD4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSETD4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSETD4
Mutations and Diseases : HGMDSETD4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSETD4
DgiDB (Drug Gene Interaction Database)SETD4
DoCM (Curated mutations)SETD4
CIViC (Clinical Interpretations of Variants in Cancer)SETD4
Cancer3DSETD4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETSETD4
MedgenSETD4
Genetic Testing Registry SETD4
NextProtQ9NVD3 [Medical]
GENETestsSETD4
Target ValidationSETD4
Huge Navigator SETD4 [HugePedia]
ClinGenSETD4
Clinical trials, drugs, therapy
MyCancerGenomeSETD4
Protein Interactions : CTDSETD4
Pharm GKB GenePA25814
PharosQ9NVD3
Clinical trialSETD4
Miscellaneous
canSAR (ICR)SETD4
HarmonizomeSETD4
DataMed IndexSETD4
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSETD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:20:19 CEST 2021

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