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SETD6 (SET domain containing 6)

Identity

Alias_symbol (synonym)FLJ21148
Other alias-
HGNC (Hugo) SETD6
LocusID (NCBI) 79918
Atlas_Id 56371
Location 16q21  [Link to chromosome band 16q21]
Location_base_pair Starts at 58515479 and ends at 58520532 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CTIF (18q21.1) / SETD6 (16q21)RAB1B (11q13.2) / SETD6 (16q21)SETD6 (16q21) / CTIF (18q21.1)
SETD6 (16q21) / SETD6 (16q21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SETD6   26116
Cards
Entrez_Gene (NCBI)SETD6  79918  SET domain containing 6
Aliases
GeneCards (Weizmann)SETD6
Ensembl hg19 (Hinxton)ENSG00000103037 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103037 [Gene_View]  chr16:58515479-58520532 [Contig_View]  SETD6 [Vega]
ICGC DataPortalENSG00000103037
TCGA cBioPortalSETD6
AceView (NCBI)SETD6
Genatlas (Paris)SETD6
WikiGenes79918
SOURCE (Princeton)SETD6
Genetics Home Reference (NIH)SETD6
Genomic and cartography
GoldenPath hg38 (UCSC)SETD6  -     chr16:58515479-58520532 +  16q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SETD6  -     16q21   [Description]    (hg19-Feb_2009)
EnsemblSETD6 - 16q21 [CytoView hg19]  SETD6 - 16q21 [CytoView hg38]
Mapping of homologs : NCBISETD6 [Mapview hg19]  SETD6 [Mapview hg38]
OMIM616424   
Gene and transcription
Genbank (Entrez)AK024801 AK127136 AK290495 AK297288 AK304822
RefSeq transcript (Entrez)NM_001160305 NM_024860
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SETD6
Cluster EST : UnigeneHs.731691 [ NCBI ]
CGAP (NCI)Hs.731691
Alternative Splicing GalleryENSG00000103037
Gene ExpressionSETD6 [ NCBI-GEO ]   SETD6 [ EBI - ARRAY_EXPRESS ]   SETD6 [ SEEK ]   SETD6 [ MEM ]
Gene Expression Viewer (FireBrowse)SETD6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79918
GTEX Portal (Tissue expression)SETD6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TBK2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TBK2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TBK2
Splice isoforms : SwissVarQ8TBK2
Catalytic activity : Enzyme2.1.1.- [ Enzyme-Expasy ]   2.1.1.-2.1.1.- [ IntEnz-EBI ]   2.1.1.- [ BRENDA ]   2.1.1.- [ KEGG ]   
PhosPhoSitePlusQ8TBK2
Domaine pattern : Prosite (Expaxy)SET (PS50280)   
Domains : Interpro (EBI)N-lys_methylase_SETD6    Rubisco_LSMT_subst-bd    SET_dom   
Domain families : Pfam (Sanger)Rubis-subs-bind (PF09273)    SET (PF00856)   
Domain families : Pfam (NCBI)pfam09273    pfam00856   
Conserved Domain (NCBI)SETD6
DMDM Disease mutations79918
Blocks (Seattle)SETD6
PDB (SRS)3QXY    3RC0   
PDB (PDBSum)3QXY    3RC0   
PDB (IMB)3QXY    3RC0   
PDB (RSDB)3QXY    3RC0   
Structural Biology KnowledgeBase3QXY    3RC0   
SCOP (Structural Classification of Proteins)3QXY    3RC0   
CATH (Classification of proteins structures)3QXY    3RC0   
SuperfamilyQ8TBK2
Human Protein AtlasENSG00000103037
Peptide AtlasQ8TBK2
HPRD07956
IPIIPI00290785   IPI00016345   IPI00909955   IPI00444752   IPI00877849   IPI00878242   IPI00878050   IPI00878603   IPI00878378   
Protein Interaction databases
DIP (DOE-UCLA)Q8TBK2
IntAct (EBI)Q8TBK2
FunCoupENSG00000103037
BioGRIDSETD6
STRING (EMBL)SETD6
ZODIACSETD6
Ontologies - Pathways
QuickGOQ8TBK2
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytosol  protein-lysine N-methyltransferase activity  protein-lysine N-methyltransferase activity  peptidyl-lysine monomethylation  stem cell population maintenance  negative regulation of NF-kappaB transcription factor activity  histone lysine methylation  stem cell differentiation  regulation of inflammatory response  NF-kappaB binding  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytosol  protein-lysine N-methyltransferase activity  protein-lysine N-methyltransferase activity  peptidyl-lysine monomethylation  stem cell population maintenance  negative regulation of NF-kappaB transcription factor activity  histone lysine methylation  stem cell differentiation  regulation of inflammatory response  NF-kappaB binding  
NDEx NetworkSETD6
Atlas of Cancer Signalling NetworkSETD6
Wikipedia pathwaysSETD6
Orthology - Evolution
OrthoDB79918
GeneTree (enSembl)ENSG00000103037
Phylogenetic Trees/Animal Genes : TreeFamSETD6
HOVERGENQ8TBK2
HOGENOMQ8TBK2
Homologs : HomoloGeneSETD6
Homology/Alignments : Family Browser (UCSC)SETD6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSETD6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SETD6
dbVarSETD6
ClinVarSETD6
1000_GenomesSETD6 
Exome Variant ServerSETD6
ExAC (Exome Aggregation Consortium)SETD6 (select the gene name)
Genetic variants : HAPMAP79918
Genomic Variants (DGV)SETD6 [DGVbeta]
DECIPHERSETD6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSETD6 
Mutations
ICGC Data PortalSETD6 
TCGA Data PortalSETD6 
Broad Tumor PortalSETD6
OASIS PortalSETD6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSETD6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSETD6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SETD6
DgiDB (Drug Gene Interaction Database)SETD6
DoCM (Curated mutations)SETD6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SETD6 (select a term)
intoGenSETD6
Cancer3DSETD6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616424   
Orphanet
MedgenSETD6
Genetic Testing Registry SETD6
NextProtQ8TBK2 [Medical]
TSGene79918
GENETestsSETD6
Target ValidationSETD6
Huge Navigator SETD6 [HugePedia]
snp3D : Map Gene to Disease79918
BioCentury BCIQSETD6
ClinGenSETD6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79918
Chemical/Pharm GKB GenePA143485614
Clinical trialSETD6
Miscellaneous
canSAR (ICR)SETD6 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSETD6
EVEXSETD6
GoPubMedSETD6
iHOPSETD6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:55:06 CEST 2017

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