SETD6 (SET domain containing 6, protein lysine methyltransferase)

2016-10-01  

Identity

HGNC
SETD6
LOCATION
16q21
LOCUSID
79918
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79918
MIM: 616424
HGNC: 26116
Ensembl: ENSG00000103037

Variants:

dbSNP: 79918
ClinVar: 79918
TCGA: ENSG00000103037
COSMIC: SETD6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103037ENST00000219315Q8TBK2
ENSG00000103037ENST00000310682Q8TBK2
ENSG00000103037ENST00000394266J3QT10
ENSG00000103037ENST00000422445H7C3N0
ENSG00000103037ENST00000427443E9PC53
ENSG00000103037ENST00000447443C9JCR1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
211319672011Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling.112
211319672011Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling.112
233246262013SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal.19
247517162014SETD6 controls the expression of estrogen-responsive genes and proliferation of breast carcinoma cells.12
268418652016PAK4 Methylation by SETD6 Promotes the Activation of the Wnt/β-Catenin Pathway.12
267803262016SETD6 is a negative regulator of oxidative stress response.9
281223462017SETD6 regulates NF-κB signaling in urothelial cell survival: Implications for bladder cancer.9
306221822019The methyltransferase SETD6 regulates Mitotic progression through PLK1 methylation.7
289733562017SETD6 dominant negative mutation in familial colorectal cancer type X.6
302265782018Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration.1

Citation

Dessen P

SETD6 (SET domain containing 6, protein lysine methyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56371/setd6