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SF1 (splicing factor 1)

Identity

Alias_namesZNF162
zinc finger protein 162
Alias_symbol (synonym)ZFM1
ZCCHC25
Other aliasBBP
D11S636
MBBP
HGNC (Hugo) SF1
LocusID (NCBI) 7536
Atlas_Id 42274
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 64764604 and ends at 64778466 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CAPNS1 (19q13.12) / SF1 (11q13.1)MYOT (5q31.2) / SF1 (11q13.1)NEAT1 (11q13.1) / SF1 (11q13.1)
RNF121 (11q13.4) / SF1 (11q13.1)SF1 (11q13.1) / CGA (6q14.3)SF1 (11q13.1) / ITPR1 (3p26.1)
SF1 (11q13.1) / NAB1 (2q32.2)SF1 (11q13.1) / SF1 (11q13.1)SF1 (11q13.1) / SYT7 (11q12.2)
SF1 (11q13.1) / ZFP28 (19q13.43)SF3B3 (16q22.1) / SF1 (11q13.1)RNF121 11q13.4 / SF1 11q13.1
SF1 11q13.1 / ITPR1 3p26.1SF1 11q13.1 / SYT7 11q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SF1   12950
LRG (Locus Reference Genomic)LRG_617
Cards
Entrez_Gene (NCBI)SF1  7536  splicing factor 1
AliasesBBP; D11S636; MBBP; ZCCHC25; 
ZFM1; ZNF162
GeneCards (Weizmann)SF1
Ensembl hg19 (Hinxton)ENSG00000168066 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168066 [Gene_View]  chr11:64764604-64778466 [Contig_View]  SF1 [Vega]
ICGC DataPortalENSG00000168066
TCGA cBioPortalSF1
AceView (NCBI)SF1
Genatlas (Paris)SF1
WikiGenes7536
SOURCE (Princeton)SF1
Genetics Home Reference (NIH)SF1
Genomic and cartography
GoldenPath hg38 (UCSC)SF1  -     chr11:64764604-64778466 -  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SF1  -     11q13.1   [Description]    (hg19-Feb_2009)
EnsemblSF1 - 11q13.1 [CytoView hg19]  SF1 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBISF1 [Mapview hg19]  SF1 [Mapview hg38]
OMIM601516   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001178030 NM_001178031 NM_001346363 NM_001346364 NM_001346409 NM_001346410 NM_004630 NM_201995 NM_201997 NM_201998
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SF1
Cluster EST : UnigeneHs.502829 [ NCBI ]
CGAP (NCI)Hs.502829
Alternative Splicing GalleryENSG00000168066
Gene ExpressionSF1 [ NCBI-GEO ]   SF1 [ EBI - ARRAY_EXPRESS ]   SF1 [ SEEK ]   SF1 [ MEM ]
Gene Expression Viewer (FireBrowse)SF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7536
GTEX Portal (Tissue expression)SF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15637   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15637  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15637
Splice isoforms : SwissVarQ15637
PhosPhoSitePlusQ15637
Domaine pattern : Prosite (Expaxy)KH_TYPE_1 (PS50084)    ZF_CCHC (PS50158)   
Domains : Interpro (EBI)BBP/SF1    KH_dom    KH_dom_type_1    SF1-HH    Znf_CCHC   
Domain families : Pfam (Sanger)KH_1 (PF00013)    SF1-HH (PF16275)    zf-CCHC (PF00098)   
Domain families : Pfam (NCBI)pfam00013    pfam16275    pfam00098   
Domain families : Smart (EMBL)KH (SM00322)  ZnF_C2HC (SM00343)  
Conserved Domain (NCBI)SF1
DMDM Disease mutations7536
Blocks (Seattle)SF1
PDB (SRS)1K1G    1O0P    1OPI    2M09    2M0G    4FXW    4FXX   
PDB (PDBSum)1K1G    1O0P    1OPI    2M09    2M0G    4FXW    4FXX   
PDB (IMB)1K1G    1O0P    1OPI    2M09    2M0G    4FXW    de/coimbin/ImgLib.pl?CODE=4FXX TARGET=PDB>4FXX   
PDB (RSDB)1K1G    1O0P    1OPI    2M09    2M0G    4FXW    4FXX   
Structural Biology KnowledgeBase1K1G    1O0P    1OPI    2M09    2M0G    4FXW    4FXX   
SCOP (Structural Classification of Proteins)1K1G    1O0P    1OPI    2M09    2M0G    4FXW    4FXX   
CATH (Classification of proteins structures)1K1G    1O0P    1OPI    2M09    2M0G    4FXW    4FXX   
SuperfamilyQ15637
Human Protein AtlasENSG00000168066
Peptide AtlasQ15637
HPRD03306
IPIIPI00386114   IPI00294627   IPI00386117   IPI00941553   IPI00386119   IPI00386120   IPI00984197   IPI00386118   IPI00852591   IPI00383251   IPI00893251   IPI00917108   IPI00927404   IPI00945721   
Protein Interaction databases
DIP (DOE-UCLA)Q15637
IntAct (EBI)Q15637
FunCoupENSG00000168066
BioGRIDSF1
STRING (EMBL)SF1
ZODIACSF1
Ontologies - Pathways
QuickGOQ15637
Ontology : AmiGOspliceosomal complex assembly  mRNA 3'-splice site recognition  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  transcription corepressor activity  RNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  spliceosomal complex  ribosome  transcription, DNA-templated  regulation of transcription, DNA-templated  zinc ion binding  nuclear body  male sex determination  nuclear body organization  Leydig cell differentiation  identical protein binding  pre-mRNA branch point binding  negative regulation of smooth muscle cell proliferation  regulation of steroid biosynthetic process  negative regulation of nucleic acid-templated transcription  
Ontology : EGO-EBIspliceosomal complex assembly  mRNA 3'-splice site recognition  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  transcription corepressor activity  RNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  spliceosomal complex  ribosome  transcription, DNA-templated  regulation of transcription, DNA-templated  zinc ion binding  nuclear body  male sex determination  nuclear body organization  Leydig cell differentiation  identical protein binding  pre-mRNA branch point binding  negative regulation of smooth muscle cell proliferation  regulation of steroid biosynthetic process  negative regulation of nucleic acid-templated transcription  
NDEx NetworkSF1
Atlas of Cancer Signalling NetworkSF1
Wikipedia pathwaysSF1
Orthology - Evolution
OrthoDB7536
GeneTree (enSembl)ENSG00000168066
Phylogenetic Trees/Animal Genes : TreeFamSF1
HOVERGENQ15637
HOGENOMQ15637
Homologs : HomoloGeneSF1
Homology/Alignments : Family Browser (UCSC)SF1
Gene fusions - Rearrangements
Fusion : MitelmanRNF121/SF1 [11q13.4/11q13.1]  [t(11;11)(q13;q13)]  
Fusion : MitelmanSF1/ITPR1 [11q13.1/3p26.1]  [t(3;11)(p26;q13)]  
Fusion : MitelmanSF1/SYT7 [11q13.1/11q12.2]  [t(11;11)(q12;q13)]  
Fusion: TCGARNF121 11q13.4 SF1 11q13.1 BRCA
Fusion: TCGASF1 11q13.1 ITPR1 3p26.1 BRCA
Fusion: TCGASF1 11q13.1 SYT7 11q12.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SF1
dbVarSF1
ClinVarSF1
1000_GenomesSF1 
Exome Variant ServerSF1
ExAC (Exome Aggregation Consortium)SF1 (select the gene name)
Genetic variants : HAPMAP7536
Genomic Variants (DGV)SF1 [DGVbeta]
DECIPHERSF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSF1 
Mutations
ICGC Data PortalSF1 
TCGA Data PortalSF1 
Broad Tumor PortalSF1
OASIS PortalSF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SF1
DgiDB (Drug Gene Interaction Database)SF1
DoCM (Curated mutations)SF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SF1 (select a term)
intoGenSF1
Cancer3DSF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601516   
Orphanet
MedgenSF1
Genetic Testing Registry SF1
NextProtQ15637 [Medical]
TSGene7536
GENETestsSF1
Target ValidationSF1
Huge Navigator SF1 [HugePedia]
snp3D : Map Gene to Disease7536
BioCentury BCIQSF1
ClinGenSF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7536
Chemical/Pharm GKB GenePA37533
Clinical trialSF1
Miscellaneous
canSAR (ICR)SF1 (select the gene name)
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSF1
EVEXSF1
GoPubMedSF1
iHOPSF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 25 19:30:45 CEST 2017

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