SF1 (splicing factor 1)

2003-02-01  

Identity

HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
BBP,D11S636,MBBP,ZCCHC25,ZFM1,ZNF162
FUSION GENES

Other Information

Locus ID:

NCBI: 7536
MIM: 601516
HGNC: 12950
Ensembl: ENSG00000168066

Variants:

dbSNP: 7536
ClinVar: 7536
TCGA: ENSG00000168066
COSMIC: SF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168066ENST00000227503Q15637
ENSG00000168066ENST00000227503A0A024R588
ENSG00000168066ENST00000334944Q15637
ENSG00000168066ENST00000334944A0A024R5D9
ENSG00000168066ENST00000377387Q15637
ENSG00000168066ENST00000377390Q15637
ENSG00000168066ENST00000377390A0A024R572
ENSG00000168066ENST00000377394Q15637
ENSG00000168066ENST00000377394A0A024R566
ENSG00000168066ENST00000413725H7C0N4
ENSG00000168066ENST00000413951F8WEG7
ENSG00000168066ENST00000432725C9J792
ENSG00000168066ENST00000433274Q15637
ENSG00000168066ENST00000443908H7BZT1
ENSG00000168066ENST00000448404F8WEV5
ENSG00000168066ENST00000486867H7C561
ENSG00000168066ENST00000626028F8WEV5

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
116919922001Structural basis for recognition of the intron branch site RNA by splicing factor 1.92
156473712005Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo.63
189740542009Dimerization and protein binding specificity of the U2AF homology motif of the splicing factor Puf60.29
210628072011Analysis of in situ pre-mRNA targets of human splicing factor SF1 reveals a function in alternative splicing.24
173834262007Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing.23
251452642014Formation of nuclear bodies by the lncRNA Gomafu-associating proteins Celf3 and SF1.22
182854582008Splicing factors SF1 and U2AF associate in extraspliceosomal complexes.19
232734252013Structure of phosphorylated SF1 bound to U2AF⁶⁵ in an essential splicing factor complex.12
264208262015Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.12
256059642015Prp40 pre-mRNA processing factor 40 homolog B (PRPF40B) associates with SF1 and U2AF65 and modulates alternative pre-mRNA splicing in vivo.10

Citation

Dessen P

SF1 (splicing factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42274/sf1