SFI1 (SFI1 centrin binding protein)

2014-08-01  

Identity

HGNC
LOCATION
22q12.2
LOCUSID
ALIAS
PISD,PPP1R139,hSfi1p
FUSION GENES

Other Information

Locus ID:

NCBI: 9814
MIM: 612765
HGNC: 29064
Ensembl: ENSG00000198089

Variants:

dbSNP: 9814
ClinVar: 9814
TCGA: ENSG00000198089
COSMIC: SFI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198089ENST00000400288A8K8P3
ENSG00000198089ENST00000400289A8K8P3
ENSG00000198089ENST00000411518F8WBU4
ENSG00000198089ENST00000417682H0Y5I7
ENSG00000198089ENST00000425671H0Y836
ENSG00000198089ENST00000432498A8K8P3
ENSG00000198089ENST00000443011D3YTJ2
ENSG00000198089ENST00000444859X6RJF9
ENSG00000198089ENST00000450787H7BZF3
ENSG00000198089ENST00000452250H7C2F1
ENSG00000198089ENST00000524296E5RJU6
ENSG00000198089ENST00000540643A8K8P3

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

References

Pubmed IDYearTitleCitations
198575002010Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex.13
311970302019SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL.1
269238032016A chirality change in XPC- and Sfi1-derived peptides affects their affinity for centrin.0

Citation

Dessen P

SFI1 (SFI1 centrin binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54614/sfi1