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SFMBT2 (Scm-like with four mbt domains 2)

Identity

Alias_namesScm-related gene containing four mbt domains 2
Alias_symbol (synonym)KIAA1617
Other alias-
HGNC (Hugo) SFMBT2
LocusID (NCBI) 57713
Atlas_Id 53482
Location 10p14  [Link to chromosome band 10p14]
Location_base_pair Starts at 7158624 and ends at 7409341 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DIP2C (10p15.3) / SFMBT2 (10p14)SFMBT2 (10p14) / PRKACB (1p31.1)SFMBT2 (10p14) / TGM2 (20q11.23)
SIK3 (11q23.3) / SFMBT2 (10p14)SFMBT2 10p14 / TGM2 20q11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)SFMBT2   20256
Cards
Entrez_Gene (NCBI)SFMBT2  57713  Scm-like with four mbt domains 2
Aliases
GeneCards (Weizmann)SFMBT2
Ensembl hg19 (Hinxton)ENSG00000198879 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198879 [Gene_View]  chr10:7158624-7409341 [Contig_View]  SFMBT2 [Vega]
ICGC DataPortalENSG00000198879
TCGA cBioPortalSFMBT2
AceView (NCBI)SFMBT2
Genatlas (Paris)SFMBT2
WikiGenes57713
SOURCE (Princeton)SFMBT2
Genetics Home Reference (NIH)SFMBT2
Genomic and cartography
GoldenPath hg38 (UCSC)SFMBT2  -     chr10:7158624-7409341 -  10p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SFMBT2  -     10p14   [Description]    (hg19-Feb_2009)
EnsemblSFMBT2 - 10p14 [CytoView hg19]  SFMBT2 - 10p14 [CytoView hg38]
Mapping of homologs : NCBISFMBT2 [Mapview hg19]  SFMBT2 [Mapview hg38]
OMIM615392   
Gene and transcription
Genbank (Entrez)AB046837 AK057130 AK090887 BC067242 BC144327
RefSeq transcript (Entrez)NM_001018039 NM_001029880
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SFMBT2
Cluster EST : UnigeneHs.407983 [ NCBI ]
CGAP (NCI)Hs.407983
Alternative Splicing GalleryENSG00000198879
Gene ExpressionSFMBT2 [ NCBI-GEO ]   SFMBT2 [ EBI - ARRAY_EXPRESS ]   SFMBT2 [ SEEK ]   SFMBT2 [ MEM ]
Gene Expression Viewer (FireBrowse)SFMBT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57713
GTEX Portal (Tissue expression)SFMBT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5VUG0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5VUG0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5VUG0
Splice isoforms : SwissVarQ5VUG0
PhosPhoSitePlusQ5VUG0
Domaine pattern : Prosite (Expaxy)MBT (PS51079)   
Domains : Interpro (EBI)Mbt    SAM    SAM/pointed    SLED   
Domain families : Pfam (Sanger)MBT (PF02820)    SAM_1 (PF00536)    SLED (PF12140)   
Domain families : Pfam (NCBI)pfam02820    pfam00536    pfam12140   
Domain families : Smart (EMBL)MBT (SM00561)  SAM (SM00454)  
Conserved Domain (NCBI)SFMBT2
DMDM Disease mutations57713
Blocks (Seattle)SFMBT2
PDB (SRS)1WJR   
PDB (PDBSum)1WJR   
PDB (IMB)1WJR   
PDB (RSDB)1WJR   
Structural Biology KnowledgeBase1WJR   
SCOP (Structural Classification of Proteins)1WJR   
CATH (Classification of proteins structures)1WJR   
SuperfamilyQ5VUG0
Human Protein AtlasENSG00000198879
Peptide AtlasQ5VUG0
IPIIPI00010970   IPI00514854   IPI00513901   
Protein Interaction databases
DIP (DOE-UCLA)Q5VUG0
IntAct (EBI)Q5VUG0
FunCoupENSG00000198879
BioGRIDSFMBT2
STRING (EMBL)SFMBT2
ZODIACSFMBT2
Ontologies - Pathways
QuickGOQ5VUG0
Ontology : AmiGOprotein binding  nucleus  regulation of transcription, DNA-templated  negative regulation of gene expression  aggresome  nuclear speck  histone binding  intracellular membrane-bounded organelle  
Ontology : EGO-EBIprotein binding  nucleus  regulation of transcription, DNA-templated  negative regulation of gene expression  aggresome  nuclear speck  histone binding  intracellular membrane-bounded organelle  
NDEx NetworkSFMBT2
Atlas of Cancer Signalling NetworkSFMBT2
Wikipedia pathwaysSFMBT2
Orthology - Evolution
OrthoDB57713
GeneTree (enSembl)ENSG00000198879
Phylogenetic Trees/Animal Genes : TreeFamSFMBT2
HOVERGENQ5VUG0
HOGENOMQ5VUG0
Homologs : HomoloGeneSFMBT2
Homology/Alignments : Family Browser (UCSC)SFMBT2
Gene fusions - Rearrangements
Fusion : MitelmanSFMBT2/PRKACB [10p14/1p31.1]  
Fusion : MitelmanSFMBT2/TGM2 [10p14/20q11.23]  [t(10;20)(p14;q11)]  
Fusion: TCGASFMBT2 10p14 TGM2 20q11.23 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSFMBT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SFMBT2
dbVarSFMBT2
ClinVarSFMBT2
1000_GenomesSFMBT2 
Exome Variant ServerSFMBT2
ExAC (Exome Aggregation Consortium)SFMBT2 (select the gene name)
Genetic variants : HAPMAP57713
Genomic Variants (DGV)SFMBT2 [DGVbeta]
DECIPHERSFMBT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSFMBT2 
Mutations
ICGC Data PortalSFMBT2 
TCGA Data PortalSFMBT2 
Broad Tumor PortalSFMBT2
OASIS PortalSFMBT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSFMBT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSFMBT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SFMBT2
DgiDB (Drug Gene Interaction Database)SFMBT2
DoCM (Curated mutations)SFMBT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SFMBT2 (select a term)
intoGenSFMBT2
Cancer3DSFMBT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615392   
Orphanet
MedgenSFMBT2
Genetic Testing Registry SFMBT2
NextProtQ5VUG0 [Medical]
TSGene57713
GENETestsSFMBT2
Target ValidationSFMBT2
Huge Navigator SFMBT2 [HugePedia]
snp3D : Map Gene to Disease57713
BioCentury BCIQSFMBT2
ClinGenSFMBT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57713
Chemical/Pharm GKB GenePA134866013
Clinical trialSFMBT2
Miscellaneous
canSAR (ICR)SFMBT2 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSFMBT2
EVEXSFMBT2
GoPubMedSFMBT2
iHOPSFMBT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:30:47 CEST 2017

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