Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SFN (stratifin)

Identity

Alias_symbol (synonym)YWHAS
Other alias
HGNC (Hugo) SFN
LocusID (NCBI) 2810
Atlas_Id 42275
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 26863138 and ends at 26864457 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NUMA1 (11q13.4) / SFN (1p36.11)PRRC2A (6p21.33) / SFN (1p36.11)SFN (1p36.11) / ELK3 (12q23.1)
NUMA1 11q13.4 / SFN 1p36.11PRRC2A 6p21.33 / SFN 1p36.11SFN 1p36.11 / ELK3 12q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(1;6)(p36;p21) PRRC2A/SFN
t(1;11)(p36;q13) NUMA1/SFN
t(1;12)(p36;q23) SFN/ELK3

External links

Nomenclature
HGNC (Hugo)SFN   10773
Cards
Entrez_Gene (NCBI)SFN  2810  stratifin
AliasesYWHAS
GeneCards (Weizmann)SFN
Ensembl hg19 (Hinxton)ENSG00000175793 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175793 [Gene_View]  ENSG00000175793 [Sequence]  chr1:26863138-26864457 [Contig_View]  SFN [Vega]
ICGC DataPortalENSG00000175793
TCGA cBioPortalSFN
AceView (NCBI)SFN
Genatlas (Paris)SFN
WikiGenes2810
SOURCE (Princeton)SFN
Genetics Home Reference (NIH)SFN
Genomic and cartography
GoldenPath hg38 (UCSC)SFN  -     chr1:26863138-26864457 +  1p36.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SFN  -     1p36.11   [Description]    (hg19-Feb_2009)
EnsemblSFN - 1p36.11 [CytoView hg19]  SFN - 1p36.11 [CytoView hg38]
Mapping of homologs : NCBISFN [Mapview hg19]  SFN [Mapview hg38]
OMIM601290   
Gene and transcription
Genbank (Entrez)AF029082 BC000329 BC000995 BC001550 BC002995
RefSeq transcript (Entrez)NM_006142
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SFN
Cluster EST : UnigeneHs.523718 [ NCBI ]
CGAP (NCI)Hs.523718
Alternative Splicing GalleryENSG00000175793
Gene ExpressionSFN [ NCBI-GEO ]   SFN [ EBI - ARRAY_EXPRESS ]   SFN [ SEEK ]   SFN [ MEM ]
Gene Expression Viewer (FireBrowse)SFN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2810
GTEX Portal (Tissue expression)SFN
Human Protein AtlasENSG00000175793-SFN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31947   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31947  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31947
Splice isoforms : SwissVarP31947
PhosPhoSitePlusP31947
Domaine pattern : Prosite (Expaxy)1433_1 (PS00796)    1433_2 (PS00797)   
Domains : Interpro (EBI)14-3-3    14-3-3_CS    14-3-3_domain   
Domain families : Pfam (Sanger)14-3-3 (PF00244)   
Domain families : Pfam (NCBI)pfam00244   
Domain families : Smart (EMBL)14_3_3 (SM00101)  
Conserved Domain (NCBI)SFN
DMDM Disease mutations2810
Blocks (Seattle)SFN
PDB (SRS)1YWT    1YZ5    3IQJ    3IQU    3IQV    3LW1    3MHR    3O8I    3P1N    3P1O    3P1P    3P1Q    3P1R    3P1S    3SMK    3SML    3SMM    3SMN    3SMO    3SP5    3SPR    3T0L    3T0M    3U9X    3UX0    4DAT    4DAU    4DHM    4DHN    4DHO    4DHP    4DHQ    4DHR    4DHS    4DHT    4DHU    4FL5    4FR3    4HQW    4HRU    4IEA    4JC3    4JDD    4QLI    4Y32    4Y3B    4Y5I    5BTV    5HF3    5LTW    5LU1    5LU2   
PDB (PDBSum)1YWT    1YZ5    3IQJ    3IQU    3IQV    3LW1    3MHR    3O8I    3P1N    3P1O    3P1P    3P1Q    3P1R    3P1S    3SMK    3SML    3SMM    3SMN    3SMO    3SP5    3SPR    3T0L    3T0M    3U9X    3UX0    4DAT    4DAU    4DHM    4DHN    4DHO    4DHP    4DHQ    4DHR    4DHS    4DHT    4DHU    4FL5    4FR3    4HQW    4HRU    4IEA    4JC3    4JDD    4QLI    4Y32    4Y3B    4Y5I    5BTV    5HF3    5LTW    5LU1    5LU2   
PDB (IMB)1YWT    1YZ5    3IQJ    3IQU    3IQV    3LW1    3MHR    3O8I    3P1N    3P1O    3P1P    3P1Q    3P1R    3P1S    3SMK    3SML    3SMM    3SMN    3SMO    3SP5    3SPR    3T0L    3T0M    3U9X    3UX0    4DAT    4DAU    4DHM    4DHN    4DHO    4DHP    4DHQ    4DHR    4DHS    4DHT    4DHU    4FL5    4FR3    4HQW    4HRU    4IEA    4JC3    4JDD    4QLI    4Y32    4Y3B    4Y5I    5BTV    5HF3    5LTW    5LU1    5LU2   
PDB (RSDB)1YWT    1YZ5    3IQJ    3IQU    3IQV    3LW1    3MHR    3O8I    3P1N    3P1O    3P1P    3P1Q    3P1R    3P1S    3SMK    3SML    3SMM    3SMN    3SMO    3SP5    3SPR    3T0L    3T0M    3U9X    3UX0    4DAT    4DAU    4DHM    4DHN    4DHO    4DHP    4DHQ    4DHR    4DHS    4DHT    4DHU    4FL5    4FR3    4HQW    4HRU    4IEA    4JC3    4JDD    4QLI    4Y32    4Y3B    4Y5I    5BTV    5HF3    5LTW    5LU1    5LU2   
Structural Biology KnowledgeBase1YWT    1YZ5    3IQJ    3IQU    3IQV    3LW1    3MHR    3O8I    3P1N    3P1O    3P1P    3P1Q    3P1R    3P1S    3SMK    3SML    3SMM    3SMN    3SMO    3SP5    3SPR    3T0L    3T0M    3U9X    3UX0    4DAT    4DAU    4DHM    4DHN    4DHO    4DHP    4DHQ    4DHR    4DHS    4DHT    4DHU    4FL5    4FR3    4HQW    4HRU    4IEA    4JC3    4JDD    4QLI    4Y32    4Y3B    4Y5I    5BTV    5HF3    5LTW    5LU1    5LU2   
SCOP (Structural Classification of Proteins)1YWT    1YZ5    3IQJ    3IQU    3IQV    3LW1    3MHR    3O8I    3P1N    3P1O    3P1P    3P1Q    3P1R    3P1S    3SMK    3SML    3SMM    3SMN    3SMO    3SP5    3SPR    3T0L    3T0M    3U9X    3UX0    4DAT    4DAU    4DHM    4DHN    4DHO    4DHP    4DHQ    4DHR    4DHS    4DHT    4DHU    4FL5    4FR3    4HQW    4HRU    4IEA    4JC3    4JDD    4QLI    4Y32    4Y3B    4Y5I    5BTV    5HF3    5LTW    5LU1    5LU2   
CATH (Classification of proteins structures)1YWT    1YZ5    3IQJ    3IQU    3IQV    3LW1    3MHR    3O8I    3P1N    3P1O    3P1P    3P1Q    3P1R    3P1S    3SMK    3SML    3SMM    3SMN    3SMO    3SP5    3SPR    3T0L    3T0M    3U9X    3UX0    4DAT    4DAU    4DHM    4DHN    4DHO    4DHP    4DHQ    4DHR    4DHS    4DHT    4DHU    4FL5    4FR3    4HQW    4HRU    4IEA    4JC3    4JDD    4QLI    4Y32    4Y3B    4Y5I    5BTV    5HF3    5LTW    5LU1    5LU2   
SuperfamilyP31947
Human Protein Atlas [tissue]ENSG00000175793-SFN [tissue]
Peptide AtlasP31947
HPRD03185
IPIIPI00013890   IPI00411765   
Protein Interaction databases
DIP (DOE-UCLA)P31947
IntAct (EBI)P31947
FunCoupENSG00000175793
BioGRIDSFN
STRING (EMBL)SFN
ZODIACSFN
Ontologies - Pathways
QuickGOP31947
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  release of cytochrome c from mitochondria  keratinocyte development  protein binding  extracellular space  nucleus  mitochondrion  cytosol  cytosol  negative regulation of protein kinase activity  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  signal transduction  protein kinase C inhibitor activity  intrinsic apoptotic signaling pathway in response to DNA damage  regulation of epidermal cell division  negative regulation of keratinocyte proliferation  protein kinase binding  protein domain specific binding  positive regulation of cell growth  cytoplasmic vesicle membrane  keratinization  identical protein binding  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  cadherin binding  positive regulation of epidermal cell differentiation  positive regulation of protein export from nucleus  phosphoprotein binding  membrane organization  establishment of skin barrier  extracellular exosome  negative regulation of protein serine/threonine kinase activity  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  release of cytochrome c from mitochondria  keratinocyte development  protein binding  extracellular space  nucleus  mitochondrion  cytosol  cytosol  negative regulation of protein kinase activity  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  signal transduction  protein kinase C inhibitor activity  intrinsic apoptotic signaling pathway in response to DNA damage  regulation of epidermal cell division  negative regulation of keratinocyte proliferation  protein kinase binding  protein domain specific binding  positive regulation of cell growth  cytoplasmic vesicle membrane  keratinization  identical protein binding  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  cadherin binding  positive regulation of epidermal cell differentiation  positive regulation of protein export from nucleus  phosphoprotein binding  membrane organization  establishment of skin barrier  extracellular exosome  negative regulation of protein serine/threonine kinase activity  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Pathways : BIOCARTAEstrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes]   
Pathways : KEGGCell cycle   
NDEx NetworkSFN
Atlas of Cancer Signalling NetworkSFN
Wikipedia pathwaysSFN
Orthology - Evolution
OrthoDB2810
GeneTree (enSembl)ENSG00000175793
Phylogenetic Trees/Animal Genes : TreeFamSFN
HOVERGENP31947
HOGENOMP31947
Homologs : HomoloGeneSFN
Homology/Alignments : Family Browser (UCSC)SFN
Gene fusions - Rearrangements
Fusion : MitelmanNUMA1/SFN [11q13.4/1p36.11]  [t(1;11)(p36;q13)]  
Fusion : MitelmanPRRC2A/SFN [6p21.33/1p36.11]  [t(1;6)(p36;p21)]  
Fusion : MitelmanSFN/ELK3 [1p36.11/12q23.1]  [t(1;12)(p36;q23)]  
Fusion PortalNUMA1 11q13.4 SFN 1p36.11 HNSC
Fusion PortalPRRC2A 6p21.33 SFN 1p36.11 HNSC
Fusion PortalSFN 1p36.11 ELK3 12q23.1 HNSC
Fusion : QuiverSFN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSFN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SFN
dbVarSFN
ClinVarSFN
1000_GenomesSFN 
Exome Variant ServerSFN
ExAC (Exome Aggregation Consortium)ENSG00000175793
GNOMAD BrowserENSG00000175793
Genetic variants : HAPMAP2810
Genomic Variants (DGV)SFN [DGVbeta]
DECIPHERSFN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSFN 
Mutations
ICGC Data PortalSFN 
TCGA Data PortalSFN 
Broad Tumor PortalSFN
OASIS PortalSFN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSFN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSFN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SFN
DgiDB (Drug Gene Interaction Database)SFN
DoCM (Curated mutations)SFN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SFN (select a term)
intoGenSFN
Cancer3DSFN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601290   
Orphanet
DisGeNETSFN
MedgenSFN
Genetic Testing Registry SFN
NextProtP31947 [Medical]
TSGene2810
GENETestsSFN
Target ValidationSFN
Huge Navigator SFN [HugePedia]
snp3D : Map Gene to Disease2810
BioCentury BCIQSFN
ClinGenSFN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2810
Chemical/Pharm GKB GenePA177
Clinical trialSFN
Miscellaneous
canSAR (ICR)SFN (select the gene name)
Probes
Litterature
PubMed212 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSFN
EVEXSFN
GoPubMedSFN
iHOPSFN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:49:20 CEST 2018
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