SFN (stratifin)

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SFN (stratifin)

Identity

Alias (NCBI)	YWHAS
HGNC (Hugo)	SFN
HGNC Alias symb	YWHAS
HGNC Alias name	14-3-3 sigma
LocusID (NCBI)	2810
Atlas_Id	42275
Location	1p36.11 [Link to chromosome band 1p36]
Location_base_pair	Starts at 26863149 and ends at 26864456 bp from pter ( according to hg38-Dec_2013)

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

NUMA1 (11q13.4) / SFN (1p36.11)	PRRC2A (6p21.33) / SFN (1p36.11)	SFN (1p36.11) / ELK3 (12q23.1)
NUMA1 11q13.4 / SFN 1p36.11	PRRC2A 6p21.33 / SFN 1p36.11	SFN 1p36.11 / ELK3 12q23.1

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	SFN 10773
	Cards
Entrez_Gene (NCBI)	SFN stratifin
Aliases	YWHAS
GeneCards (Weizmann)	SFN
Ensembl hg19 (Hinxton)	ENSG00000175793 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000175793 [Gene_View] ENSG00000175793 [Sequence] chr1:26863149-26864456 [Contig_View] SFN [Vega]
ICGC DataPortal	ENSG00000175793
TCGA cBioPortal	SFN
AceView (NCBI)	SFN
Genatlas (Paris)	SFN
SOURCE (Princeton)	SFN
Genetics Home Reference (NIH)	SFN
	Genomic and cartography
GoldenPath hg38 (UCSC)	SFN - chr1:26863149-26864456 + 1p36.11 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	SFN - 1p36.11 [Description] (hg19-Feb_2009)
GoldenPath	SFN - 1p36.11 [CytoView hg19] SFN - 1p36.11 [CytoView hg38]
ImmunoBase	ENSG00000175793
Genome Data Viewer NCBI	SFN [Mapview hg19]
OMIM	601290
	Gene and transcription
Genbank (Entrez)	AF029082 BC000329 BC000995 BC001550 BC002995
RefSeq transcript (Entrez)	NM_006142
Consensus coding sequences : CCDS (NCBI)	SFN
Gene Expression	SFN [ NCBI-GEO ] SFN [ EBI - ARRAY_EXPRESS ] SFN [ SEEK ] SFN [ MEM ]
Gene Expression Viewer (FireBrowse)	SFN [ Firebrowse - Broad ]
Genevisible	Expression of SFN in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	2810
GTEX Portal (Tissue expression)	SFN
Human Protein Atlas	ENSG00000175793-SFN [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P31947 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	P31947 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P31947
PhosPhoSitePlus	P31947
Domaine pattern : Prosite (Expaxy)	1433_1 (PS00796) 1433_2 (PS00797)
Domains : Interpro (EBI)	14-3-3 14-3-3_CS 14-3-3_dom_sf 14-3-3_domain 14-3-3_sigma
Domain families : Pfam (Sanger)	14-3-3 (PF00244)
Domain families : Pfam (NCBI)	pfam00244
Domain families : Smart (EMBL)	14_3_3 (SM00101)
Conserved Domain (NCBI)	SFN
PDB (RSDB)	1YWT 1YZ5 3IQJ 3IQU 3IQV 3LW1 3MHR 3O8I 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3T0L 3T0M 3U9X 3UX0 4DAT 4DAU 4DHM 4DHN 4DHO 4DHP 4DHQ 4DHR 4DHS 4DHT 4DHU 4FL5 4FR3 4IEA 4JC3 4JDD 4QLI 4Y32 4Y3B 4Y5I 5BTV 5HF3 5LTW 5LU1 5LU2 5MHC 5MOC 5MXO 5MY9 5MYC 5N5R 5N5T 5N5W 5N75 5OEG 5OEH 5OK9 5OKF 5OM0 5OMA 6FAU 6FAV 6FAW 6FBB 6FBW 6FBY 6FCP 6FI4 6FI5 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GHP 6HHP 6HKB 6HKF 6HMT 6HMU 6HN2 6NV2 6QDR 6QDS 6QDT 6QDU 6QHL 6QHM 6QIU 6QZR 6QZS 6R5L 6RHC 6RJL 6RJQ 6RJZ 6RK8 6RKI 6RKK 6RKM 6RL3 6RL4 6RL6 6RM5 6RM7 6RP6 6RWH 6RWI 6RWS 6RWU 6RX2 6S39 6S3C 6S40 6S9Q 6SIN 6SIO 6SIP 6SIQ 6SLV 6SLW 6SLX 6TCH 6TJM 6TL3 6TLF 6TLG 6TM7 6TWZ 6W0L 6XWD 6Y1J 6Y3M 6Y3O 6Y3R 6Y3S 6Y3V 6Y40 6Y44 6Y8A 6Y8B 6Y8D 6Y8E 6YOW 6YOX 6YOY 6YP2 6YP3 6YP8 6YPL 6YPY 6YQ2 7AEW
PDB Europe	1YWT 1YZ5 3IQJ 3IQU 3IQV 3LW1 3MHR 3O8I 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3T0L 3T0M 3U9X 3UX0 4DAT 4DAU 4DHM 4DHN 4DHO 4DHP 4DHQ 4DHR 4DHS 4DHT 4DHU 4FL5 4FR3 4IEA 4JC3 4JDD 4QLI 4Y32 4Y3B 4Y5I 5BTV 5HF3 5LTW 5LU1 5LU2 5MHC 5MOC 5MXO 5MY9 5MYC 5N5R 5N5T 5N5W 5N75 5OEG 5OEH 5OK9 5OKF 5OM0 5OMA 6FAU 6FAV 6FAW 6FBB 6FBW 6FBY 6FCP 6FI4 6FI5 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GHP 6HHP 6HKB 6HKF 6HMT 6HMU 6HN2 6NV2 6QDR 6QDS 6QDT 6QDU 6QHL 6QHM 6QIU 6QZR 6QZS 6R5L 6RHC 6RJL 6RJQ 6RJZ 6RK8 6RKI 6RKK 6RKM 6RL3 6RL4 6RL6 6RM5 6RM7 6RP6 6RWH 6RWI 6RWS 6RWU 6RX2 6S39 6S3C 6S40 6S9Q 6SIN 6SIO 6SIP 6SIQ 6SLV 6SLW 6SLX 6TCH 6TJM 6TL3 6TLF 6TLG 6TM7 6TWZ 6W0L 6XWD 6Y1J 6Y3M 6Y3O 6Y3R 6Y3S 6Y3V 6Y40 6Y44 6Y8A 6Y8B 6Y8D 6Y8E 6YOW 6YOX 6YOY 6YP2 6YP3 6YP8 6YPL 6YPY 6YQ2 7AEW
PDB (PDBSum)	1YWT 1YZ5 3IQJ 3IQU 3IQV 3LW1 3MHR 3O8I 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3T0L 3T0M 3U9X 3UX0 4DAT 4DAU 4DHM 4DHN 4DHO 4DHP 4DHQ 4DHR 4DHS 4DHT 4DHU 4FL5 4FR3 4IEA 4JC3 4JDD 4QLI 4Y32 4Y3B 4Y5I 5BTV 5HF3 5LTW 5LU1 5LU2 5MHC 5MOC 5MXO 5MY9 5MYC 5N5R 5N5T 5N5W 5N75 5OEG 5OEH 5OK9 5OKF 5OM0 5OMA 6FAU 6FAV 6FAW 6FBB 6FBW 6FBY 6FCP 6FI4 6FI5 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GHP 6HHP 6HKB 6HKF 6HMT 6HMU 6HN2 6NV2 6QDR 6QDS 6QDT 6QDU 6QHL 6QHM 6QIU 6QZR 6QZS 6R5L 6RHC 6RJL 6RJQ 6RJZ 6RK8 6RKI 6RKK 6RKM 6RL3 6RL4 6RL6 6RM5 6RM7 6RP6 6RWH 6RWI 6RWS 6RWU 6RX2 6S39 6S3C 6S40 6S9Q 6SIN 6SIO 6SIP 6SIQ 6SLV 6SLW 6SLX 6TCH 6TJM 6TL3 6TLF 6TLG 6TM7 6TWZ 6W0L 6XWD 6Y1J 6Y3M 6Y3O 6Y3R 6Y3S 6Y3V 6Y40 6Y44 6Y8A 6Y8B 6Y8D 6Y8E 6YOW 6YOX 6YOY 6YP2 6YP3 6YP8 6YPL 6YPY 6YQ2 7AEW
PDB (IMB)	1YWT 1YZ5 3IQJ 3IQU 3IQV 3LW1 3MHR 3O8I 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3T0L 3T0M 3U9X 3UX0 4DAT 4DAU 4DHM 4DHN 4DHO 4DHP 4DHQ 4DHR 4DHS 4DHT 4DHU 4FL5 4FR3 4IEA 4JC3 4JDD 4QLI 4Y32 4Y3B 4Y5I 5BTV 5HF3 5LTW 5LU1 5LU2 5MHC 5MOC 5MXO 5MY9 5MYC 5N5R 5N5T 5N5W 5N75 5OEG 5OEH 5OK9 5OKF 5OM0 5OMA 6FAU 6FAV 6FAW 6FBB 6FBW 6FBY 6FCP 6FI4 6FI5 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GHP 6HHP 6HKB 6HKF 6HMT 6HMU 6HN2 6NV2 6QDR 6QDS 6QDT 6QDU 6QHL 6QHM 6QIU 6QZR 6QZS 6R5L 6RHC 6RJL 6RJQ 6RJZ 6RK8 6RKI 6RKK 6RKM 6RL3 6RL4 6RL6 6RM5 6RM7 6RP6 6RWH 6RWI 6RWS 6RWU 6RX2 6S39 6S3C 6S40 6S9Q 6SIN 6SIO 6SIP 6SIQ 6SLV 6SLW 6SLX 6TCH 6TJM 6TL3 6TLF 6TLG 6TM7 6TWZ 6W0L 6XWD 6Y1J 6Y3M 6Y3O 6Y3R 6Y3S 6Y3V 6Y40 6Y44 6Y8A 6Y8B 6Y8D 6Y8E 6YOW 6YOX 6YOY 6YP2 6YP3 6YP8 6YPL 6YPY 6YQ2 7AEW
Structural Biology KnowledgeBase	1YWT 1YZ5 3IQJ 3IQU 3IQV 3LW1 3MHR 3O8I 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3T0L 3T0M 3U9X 3UX0 4DAT 4DAU 4DHM 4DHN 4DHO 4DHP 4DHQ 4DHR 4DHS 4DHT 4DHU 4FL5 4FR3 4IEA 4JC3 4JDD 4QLI 4Y32 4Y3B 4Y5I 5BTV 5HF3 5LTW 5LU1 5LU2 5MHC 5MOC 5MXO 5MY9 5MYC 5N5R 5N5T 5N5W 5N75 5OEG 5OEH 5OK9 5OKF 5OM0 5OMA 6FAU 6FAV 6FAW 6FBB 6FBW 6FBY 6FCP 6FI4 6FI5 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GHP 6HHP 6HKB 6HKF 6HMT 6HMU 6HN2 6NV2 6QDR 6QDS 6QDT 6QDU 6QHL 6QHM 6QIU 6QZR 6QZS 6R5L 6RHC 6RJL 6RJQ 6RJZ 6RK8 6RKI 6RKK 6RKM 6RL3 6RL4 6RL6 6RM5 6RM7 6RP6 6RWH 6RWI 6RWS 6RWU 6RX2 6S39 6S3C 6S40 6S9Q 6SIN 6SIO 6SIP 6SIQ 6SLV 6SLW 6SLX 6TCH 6TJM 6TL3 6TLF 6TLG 6TM7 6TWZ 6W0L 6XWD 6Y1J 6Y3M 6Y3O 6Y3R 6Y3S 6Y3V 6Y40 6Y44 6Y8A 6Y8B 6Y8D 6Y8E 6YOW 6YOX 6YOY 6YP2 6YP3 6YP8 6YPL 6YPY 6YQ2 7AEW
SCOP (Structural Classification of Proteins)	1YWT 1YZ5 3IQJ 3IQU 3IQV 3LW1 3MHR 3O8I 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3T0L 3T0M 3U9X 3UX0 4DAT 4DAU 4DHM 4DHN 4DHO 4DHP 4DHQ 4DHR 4DHS 4DHT 4DHU 4FL5 4FR3 4IEA 4JC3 4JDD 4QLI 4Y32 4Y3B 4Y5I 5BTV 5HF3 5LTW 5LU1 5LU2 5MHC 5MOC 5MXO 5MY9 5MYC 5N5R 5N5T 5N5W 5N75 5OEG 5OEH 5OK9 5OKF 5OM0 5OMA 6FAU 6FAV 6FAW 6FBB 6FBW 6FBY 6FCP 6FI4 6FI5 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GHP 6HHP 6HKB 6HKF 6HMT 6HMU 6HN2 6NV2 6QDR 6QDS 6QDT 6QDU 6QHL 6QHM 6QIU 6QZR 6QZS 6R5L 6RHC 6RJL 6RJQ 6RJZ 6RK8 6RKI 6RKK 6RKM 6RL3 6RL4 6RL6 6RM5 6RM7 6RP6 6RWH 6RWI 6RWS 6RWU 6RX2 6S39 6S3C 6S40 6S9Q 6SIN 6SIO 6SIP 6SIQ 6SLV 6SLW 6SLX 6TCH 6TJM 6TL3 6TLF 6TLG 6TM7 6TWZ 6W0L 6XWD 6Y1J 6Y3M 6Y3O 6Y3R 6Y3S 6Y3V 6Y40 6Y44 6Y8A 6Y8B 6Y8D 6Y8E 6YOW 6YOX 6YOY 6YP2 6YP3 6YP8 6YPL 6YPY 6YQ2 7AEW
CATH (Classification of proteins structures)	1YWT 1YZ5 3IQJ 3IQU 3IQV 3LW1 3MHR 3O8I 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3T0L 3T0M 3U9X 3UX0 4DAT 4DAU 4DHM 4DHN 4DHO 4DHP 4DHQ 4DHR 4DHS 4DHT 4DHU 4FL5 4FR3 4IEA 4JC3 4JDD 4QLI 4Y32 4Y3B 4Y5I 5BTV 5HF3 5LTW 5LU1 5LU2 5MHC 5MOC 5MXO 5MY9 5MYC 5N5R 5N5T 5N5W 5N75 5OEG 5OEH 5OK9 5OKF 5OM0 5OMA 6FAU 6FAV 6FAW 6FBB 6FBW 6FBY 6FCP 6FI4 6FI5 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GHP 6HHP 6HKB 6HKF 6HMT 6HMU 6HN2 6NV2 6QDR 6QDS 6QDT 6QDU 6QHL 6QHM 6QIU 6QZR 6QZS 6R5L 6RHC 6RJL 6RJQ 6RJZ 6RK8 6RKI 6RKK 6RKM 6RL3 6RL4 6RL6 6RM5 6RM7 6RP6 6RWH 6RWI 6RWS 6RWU 6RX2 6S39 6S3C 6S40 6S9Q 6SIN 6SIO 6SIP 6SIQ 6SLV 6SLW 6SLX 6TCH 6TJM 6TL3 6TLF 6TLG 6TM7 6TWZ 6W0L 6XWD 6Y1J 6Y3M 6Y3O 6Y3R 6Y3S 6Y3V 6Y40 6Y44 6Y8A 6Y8B 6Y8D 6Y8E 6YOW 6YOX 6YOY 6YP2 6YP3 6YP8 6YPL 6YPY 6YQ2 7AEW
Superfamily	P31947
AlphaFold pdb e-kb	P31947
Human Protein Atlas [tissue]	ENSG00000175793-SFN [tissue]
HPRD	03185
	Protein Interaction databases
DIP (DOE-UCLA)	P31947
IntAct (EBI)	P31947
BioGRID	SFN
STRING (EMBL)	SFN
ZODIAC	SFN
	Ontologies - Pathways
QuickGO	P31947
Ontology : AmiGO	regulation of cyclin-dependent protein serine/threonine kinase activity release of cytochrome c from mitochondria keratinocyte development protein binding extracellular space nucleus mitochondrion cytosol cytosol negative regulation of protein kinase activity DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest signal transduction protein kinase C inhibitor activity intrinsic apoptotic signaling pathway in response to DNA damage regulation of epidermal cell division negative regulation of keratinocyte proliferation protein kinase binding positive regulation of cell growth keratinization identical protein binding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process cadherin binding positive regulation of epidermal cell differentiation positive regulation of protein export from nucleus phosphoprotein binding establishment of skin barrier extracellular exosome positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Ontology : EGO-EBI	regulation of cyclin-dependent protein serine/threonine kinase activity release of cytochrome c from mitochondria keratinocyte development protein binding extracellular space nucleus mitochondrion cytosol cytosol negative regulation of protein kinase activity DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest signal transduction protein kinase C inhibitor activity intrinsic apoptotic signaling pathway in response to DNA damage regulation of epidermal cell division negative regulation of keratinocyte proliferation protein kinase binding positive regulation of cell growth keratinization identical protein binding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process cadherin binding positive regulation of epidermal cell differentiation positive regulation of protein export from nucleus phosphoprotein binding establishment of skin barrier extracellular exosome positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Pathways : BIOCARTA	Estrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes]
Pathways : KEGG	Cell cycle p53 signaling pathway Aldosterone-regulated sodium reabsorption
NDEx Network	SFN
Atlas of Cancer Signalling Network	SFN
Wikipedia pathways	SFN
	Orthology - Evolution
OrthoDB	2810
GeneTree (enSembl)	ENSG00000175793
Phylogenetic Trees/Animal Genes : TreeFam	SFN
Homologs : HomoloGene	SFN
Homology/Alignments : Family Browser (UCSC)	SFN
	Gene fusions - Rearrangements
Fusion : Mitelman	NUMA1/SFN [11q13.4/1p36.11]
Fusion : Mitelman	PRRC2A/SFN [6p21.33/1p36.11]
Fusion : Mitelman	SFN/ELK3 [1p36.11/12q23.1]
Fusion : Quiver	SFN
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	SFN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	SFN
dbVar	SFN
ClinVar	SFN
Monarch	SFN
1000_Genomes	SFN
Exome Variant Server	SFN
GNOMAD Browser	ENSG00000175793
Varsome Browser	SFN
ACMG	SFN variants
Varity	P31947
Genomic Variants (DGV)	SFN [DGVbeta]
DECIPHER	SFN [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	SFN
	Mutations
ICGC Data Portal	SFN
TCGA Data Portal	SFN
Broad Tumor Portal	SFN
OASIS Portal	SFN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	SFN [overview] [genome browser] [tissue] [distribution]
Somatic Mutations in Cancer : COSMIC3D	SFN
Mutations and Diseases : HGMD	SFN
LOVD (Leiden Open Variation Database)	[gene] [transcripts] [variants]
BioMuta	SFN
DgiDB (Drug Gene Interaction Database)	SFN
DoCM (Curated mutations)	SFN
CIViC (Clinical Interpretations of Variants in Cancer)	SFN
Cancer3D	SFN
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	601290
Orphanet
DisGeNET	SFN
Medgen	SFN
Genetic Testing Registry	SFN
NextProt	P31947 [Medical]
GENETests	SFN
Target Validation	SFN
Huge Navigator	SFN [HugePedia]
ClinGen	SFN
	Clinical trials, drugs, therapy
MyCancerGenome	SFN
Protein Interactions : CTD	SFN
Pharm GKB Gene	PA177
Pharos	P31947
Clinical trial	SFN
	Miscellaneous
canSAR (ICR)	SFN
Harmonizome	SFN
DataMed Index	SFN
	Probes
	Litterature
PubMed	253 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
EVEX	SFN

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Mon Oct 4 15:30:53 CEST 2021

Home Genes Leukemias Solid Tumors Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

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Atlas of Genetics and Cytogenetics in Oncology and Haematology

SFN (stratifin)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute