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SFN (stratifin)

Identity

Alias (NCBI)YWHAS
HGNC (Hugo) SFN
HGNC Alias symbYWHAS
HGNC Alias name14-3-3 sigma
LocusID (NCBI) 2810
Atlas_Id 42275
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 26863149 and ends at 26864456 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NUMA1 (11q13.4) / SFN (1p36.11)PRRC2A (6p21.33) / SFN (1p36.11)SFN (1p36.11) / ELK3 (12q23.1)
NUMA1 11q13.4 / SFN 1p36.11PRRC2A 6p21.33 / SFN 1p36.11SFN 1p36.11 / ELK3 12q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SFN   10773
Cards
Entrez_Gene (NCBI)SFN    stratifin
AliasesYWHAS
GeneCards (Weizmann)SFN
Ensembl hg19 (Hinxton)ENSG00000175793 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175793 [Gene_View]  ENSG00000175793 [Sequence]  chr1:26863149-26864456 [Contig_View]  SFN [Vega]
ICGC DataPortalENSG00000175793
TCGA cBioPortalSFN
AceView (NCBI)SFN
Genatlas (Paris)SFN
SOURCE (Princeton)SFN
Genetics Home Reference (NIH)SFN
Genomic and cartography
GoldenPath hg38 (UCSC)SFN  -     chr1:26863149-26864456 +  1p36.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SFN  -     1p36.11   [Description]    (hg19-Feb_2009)
GoldenPathSFN - 1p36.11 [CytoView hg19]  SFN - 1p36.11 [CytoView hg38]
ImmunoBaseENSG00000175793
Genome Data Viewer NCBISFN [Mapview hg19]  
OMIM601290   
Gene and transcription
Genbank (Entrez)AF029082 BC000329 BC000995 BC001550 BC002995
RefSeq transcript (Entrez)NM_006142
Consensus coding sequences : CCDS (NCBI)SFN
Gene ExpressionSFN [ NCBI-GEO ]   SFN [ EBI - ARRAY_EXPRESS ]   SFN [ SEEK ]   SFN [ MEM ]
Gene Expression Viewer (FireBrowse)SFN [ Firebrowse - Broad ]
GenevisibleExpression of SFN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2810
GTEX Portal (Tissue expression)SFN
Human Protein AtlasENSG00000175793-SFN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31947   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31947  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31947
PhosPhoSitePlusP31947
Domaine pattern : Prosite (Expaxy)1433_1 (PS00796)    1433_2 (PS00797)   
Domains : Interpro (EBI)14-3-3    14-3-3_CS    14-3-3_dom_sf    14-3-3_domain    14-3-3_sigma   
Domain families : Pfam (Sanger)14-3-3 (PF00244)   
Domain families : Pfam (NCBI)pfam00244   
Domain families : Smart (EMBL)14_3_3 (SM00101)  
Conserved Domain (NCBI)SFN
PDB (RSDB)1YWT    1YZ5    3IQJ    3IQU    3IQV    3LW1    3MHR    3O8I    3P1N    3P1O    3P1P    3P1Q    3P1R    3P1S    3SMK    3SML    3SMM    3SMN    3SMO    3SP5    3SPR    3T0L    3T0M    3U9X    3UX0    4DAT    4DAU    4DHM    4DHN    4DHO    4DHP    4DHQ    4DHR    4DHS    4DHT    4DHU    4FL5    4FR3    4IEA    4JC3    4JDD    4QLI    4Y32    4Y3B    4Y5I    5BTV    5HF3    5LTW    5LU1    5LU2    5MHC    5MOC    5MXO    5MY9    5MYC    5N5R    5N5T    5N5W    5N75    5OEG    5OEH    5OK9    5OKF    5OM0    5OMA    6FAU    6FAV    6FAW    6FBB    6FBW    6FBY    6FCP    6FI4    6FI5    6G6X    6G8I    6G8J    6G8K    6G8L    6G8P    6G8Q    6GHP    6HHP    6HKB    6HKF    6HMT    6HMU    6HN2    6NV2    6QDR    6QDS    6QDT    6QDU    6QHL    6QHM    6QIU    6QZR    6QZS    6R5L    6RHC    6RJL    6RJQ    6RJZ    6RK8    6RKI    6RKK    6RKM    6RL3    6RL4    6RL6    6RM5    6RM7    6RP6    6RWH    6RWI    6RWS    6RWU    6RX2    6S39    6S3C    6S40    6S9Q    6SIN    6SIO    6SIP    6SIQ    6SLV    6SLW    6SLX    6TCH    6TJM    6TL3    6TLF    6TLG    6TM7    6TWZ    6W0L    6XWD    6Y1J    6Y3M    6Y3O    6Y3R    6Y3S    6Y3V    6Y40    6Y44    6Y8A    6Y8B    6Y8D    6Y8E    6YOW    6YOX    6YOY    6YP2    6YP3    6YP8    6YPL    6YPY    6YQ2    7AEW   
PDB Europe1YWT    1YZ5    3IQJ    3IQU    3IQV    3LW1    3MHR    3O8I    3P1N    3P1O    3P1P    3P1Q    3P1R    3P1S    3SMK    3SML    3SMM    3SMN    3SMO    3SP5    3SPR    3T0L    3T0M    3U9X    3UX0    4DAT    4DAU    4DHM    4DHN    4DHO    4DHP    4DHQ    4DHR    4DHS    4DHT    4DHU    4FL5    4FR3    4IEA    4JC3    4JDD    4QLI    4Y32    4Y3B    4Y5I    5BTV    5HF3    5LTW    5LU1    5LU2    5MHC    5MOC    5MXO    5MY9    5MYC    5N5R    5N5T    5N5W    5N75    5OEG    5OEH    5OK9    5OKF    5OM0    5OMA    6FAU    6FAV    6FAW    6FBB    6FBW    6FBY    6FCP    6FI4    6FI5    6G6X    6G8I    6G8J    6G8K    6G8L    6G8P    6G8Q    6GHP    6HHP    6HKB    6HKF    6HMT    6HMU    6HN2    6NV2    6QDR    6QDS    6QDT    6QDU    6QHL    6QHM    6QIU    6QZR    6QZS    6R5L    6RHC    6RJL    6RJQ    6RJZ    6RK8    6RKI    6RKK    6RKM    6RL3    6RL4    6RL6    6RM5    6RM7    6RP6    6RWH    6RWI    6RWS    6RWU    6RX2    6S39    6S3C    6S40    6S9Q    6SIN    6SIO    6SIP    6SIQ    6SLV    6SLW    6SLX    6TCH    6TJM    6TL3    6TLF    6TLG    6TM7    6TWZ    6W0L    6XWD    6Y1J    6Y3M    6Y3O    6Y3R    6Y3S    6Y3V    6Y40    6Y44    6Y8A    6Y8B    6Y8D    6Y8E    6YOW    6YOX    6YOY    6YP2    6YP3    6YP8    6YPL    6YPY    6YQ2    7AEW   
PDB (PDBSum)1YWT    1YZ5    3IQJ    3IQU    3IQV    3LW1    3MHR    3O8I    3P1N    3P1O    3P1P    3P1Q    3P1R    3P1S    3SMK    3SML    3SMM    3SMN    3SMO    3SP5    3SPR    3T0L    3T0M    3U9X    3UX0    4DAT    4DAU    4DHM    4DHN    4DHO    4DHP    4DHQ    4DHR    4DHS    4DHT    4DHU    4FL5    4FR3    4IEA    4JC3    4JDD    4QLI    4Y32    4Y3B    4Y5I    5BTV    5HF3    5LTW    5LU1    5LU2    5MHC    5MOC    5MXO    5MY9    5MYC    5N5R    5N5T    5N5W    5N75    5OEG    5OEH    5OK9    5OKF    5OM0    5OMA    6FAU    6FAV    6FAW    6FBB    6FBW    6FBY    6FCP    6FI4    6FI5    6G6X    6G8I    6G8J    6G8K    6G8L    6G8P    6G8Q    6GHP    6HHP    6HKB    6HKF    6HMT    6HMU    6HN2    6NV2    6QDR    6QDS    6QDT    6QDU    6QHL    6QHM    6QIU    6QZR    6QZS    6R5L    6RHC    6RJL    6RJQ    6RJZ    6RK8    6RKI    6RKK    6RKM    6RL3    6RL4    6RL6    6RM5    6RM7    6RP6    6RWH    6RWI    6RWS    6RWU    6RX2    6S39    6S3C    6S40    6S9Q    6SIN    6SIO    6SIP    6SIQ    6SLV    6SLW    6SLX    6TCH    6TJM    6TL3    6TLF    6TLG    6TM7    6TWZ    6W0L    6XWD    6Y1J    6Y3M    6Y3O    6Y3R    6Y3S    6Y3V    6Y40    6Y44    6Y8A    6Y8B    6Y8D    6Y8E    6YOW    6YOX    6YOY    6YP2    6YP3    6YP8    6YPL    6YPY    6YQ2    7AEW   
PDB (IMB)1YWT    1YZ5    3IQJ    3IQU    3IQV    3LW1    3MHR    3O8I    3P1N    3P1O    3P1P    3P1Q    3P1R    3P1S    3SMK    3SML    3SMM    3SMN    3SMO    3SP5    3SPR    3T0L    3T0M    3U9X    3UX0    4DAT    4DAU    4DHM    4DHN    4DHO    4DHP    4DHQ    4DHR    4DHS    4DHT    4DHU    4FL5    4FR3    4IEA    4JC3    4JDD    4QLI    4Y32    4Y3B    4Y5I    5BTV    5HF3    5LTW    5LU1    5LU2    5MHC    5MOC    5MXO    5MY9    5MYC    5N5R    5N5T    5N5W    5N75    5OEG    5OEH    5OK9    5OKF    5OM0    5OMA    6FAU    6FAV    6FAW    6FBB    6FBW    6FBY    6FCP    6FI4    6FI5    6G6X    6G8I    6G8J    6G8K    6G8L    6G8P    6G8Q    6GHP    6HHP    6HKB    6HKF    6HMT    6HMU    6HN2    6NV2    6QDR    6QDS    6QDT    6QDU    6QHL    6QHM    6QIU    6QZR    6QZS    6R5L    6RHC    6RJL    6RJQ    6RJZ    6RK8    6RKI    6RKK    6RKM    6RL3    6RL4    6RL6    6RM5    6RM7    6RP6    6RWH    6RWI    6RWS    6RWU    6RX2    6S39    6S3C    6S40    6S9Q    6SIN    6SIO    6SIP    6SIQ    6SLV    6SLW    6SLX    6TCH    6TJM    6TL3    6TLF    6TLG    6TM7    6TWZ    6W0L    6XWD    6Y1J    6Y3M    6Y3O    6Y3R    6Y3S    6Y3V    6Y40    6Y44    6Y8A    6Y8B    6Y8D    6Y8E    6YOW    6YOX    6YOY    6YP2    6YP3    6YP8    6YPL    6YPY    6YQ2    7AEW   
Structural Biology KnowledgeBase1YWT    1YZ5    3IQJ    3IQU    3IQV    3LW1    3MHR    3O8I    3P1N    3P1O    3P1P    3P1Q    3P1R    3P1S    3SMK    3SML    3SMM    3SMN    3SMO    3SP5    3SPR    3T0L    3T0M    3U9X    3UX0    4DAT    4DAU    4DHM    4DHN    4DHO    4DHP    4DHQ    4DHR    4DHS    4DHT    4DHU    4FL5    4FR3    4IEA    4JC3    4JDD    4QLI    4Y32    4Y3B    4Y5I    5BTV    5HF3    5LTW    5LU1    5LU2    5MHC    5MOC    5MXO    5MY9    5MYC    5N5R    5N5T    5N5W    5N75    5OEG    5OEH    5OK9    5OKF    5OM0    5OMA    6FAU    6FAV    6FAW    6FBB    6FBW    6FBY    6FCP    6FI4    6FI5    6G6X    6G8I    6G8J    6G8K    6G8L    6G8P    6G8Q    6GHP    6HHP    6HKB    6HKF    6HMT    6HMU    6HN2    6NV2    6QDR    6QDS    6QDT    6QDU    6QHL    6QHM    6QIU    6QZR    6QZS    6R5L    6RHC    6RJL    6RJQ    6RJZ    6RK8    6RKI    6RKK    6RKM    6RL3    6RL4    6RL6    6RM5    6RM7    6RP6    6RWH    6RWI    6RWS    6RWU    6RX2    6S39    6S3C    6S40    6S9Q    6SIN    6SIO    6SIP    6SIQ    6SLV    6SLW    6SLX    6TCH    6TJM    6TL3    6TLF    6TLG    6TM7    6TWZ    6W0L    6XWD    6Y1J    6Y3M    6Y3O    6Y3R    6Y3S    6Y3V    6Y40    6Y44    6Y8A    6Y8B    6Y8D    6Y8E    6YOW    6YOX    6YOY    6YP2    6YP3    6YP8    6YPL    6YPY    6YQ2    7AEW   
SCOP (Structural Classification of Proteins)1YWT    1YZ5    3IQJ    3IQU    3IQV    3LW1    3MHR    3O8I    3P1N    3P1O    3P1P    3P1Q    3P1R    3P1S    3SMK    3SML    3SMM    3SMN    3SMO    3SP5    3SPR    3T0L    3T0M    3U9X    3UX0    4DAT    4DAU    4DHM    4DHN    4DHO    4DHP    4DHQ    4DHR    4DHS    4DHT    4DHU    4FL5    4FR3    4IEA    4JC3    4JDD    4QLI    4Y32    4Y3B    4Y5I    5BTV    5HF3    5LTW    5LU1    5LU2    5MHC    5MOC    5MXO    5MY9    5MYC    5N5R    5N5T    5N5W    5N75    5OEG    5OEH    5OK9    5OKF    5OM0    5OMA    6FAU    6FAV    6FAW    6FBB    6FBW    6FBY    6FCP    6FI4    6FI5    6G6X    6G8I    6G8J    6G8K    6G8L    6G8P    6G8Q    6GHP    6HHP    6HKB    6HKF    6HMT    6HMU    6HN2    6NV2    6QDR    6QDS    6QDT    6QDU    6QHL    6QHM    6QIU    6QZR    6QZS    6R5L    6RHC    6RJL    6RJQ    6RJZ    6RK8    6RKI    6RKK    6RKM    6RL3    6RL4    6RL6    6RM5    6RM7    6RP6    6RWH    6RWI    6RWS    6RWU    6RX2    6S39    6S3C    6S40    6S9Q    6SIN    6SIO    6SIP    6SIQ    6SLV    6SLW    6SLX    6TCH    6TJM    6TL3    6TLF    6TLG    6TM7    6TWZ    6W0L    6XWD    6Y1J    6Y3M    6Y3O    6Y3R    6Y3S    6Y3V    6Y40    6Y44    6Y8A    6Y8B    6Y8D    6Y8E    6YOW    6YOX    6YOY    6YP2    6YP3    6YP8    6YPL    6YPY    6YQ2    7AEW   
CATH (Classification of proteins structures)1YWT    1YZ5    3IQJ    3IQU    3IQV    3LW1    3MHR    3O8I    3P1N    3P1O    3P1P    3P1Q    3P1R    3P1S    3SMK    3SML    3SMM    3SMN    3SMO    3SP5    3SPR    3T0L    3T0M    3U9X    3UX0    4DAT    4DAU    4DHM    4DHN    4DHO    4DHP    4DHQ    4DHR    4DHS    4DHT    4DHU    4FL5    4FR3    4IEA    4JC3    4JDD    4QLI    4Y32    4Y3B    4Y5I    5BTV    5HF3    5LTW    5LU1    5LU2    5MHC    5MOC    5MXO    5MY9    5MYC    5N5R    5N5T    5N5W    5N75    5OEG    5OEH    5OK9    5OKF    5OM0    5OMA    6FAU    6FAV    6FAW    6FBB    6FBW    6FBY    6FCP    6FI4    6FI5    6G6X    6G8I    6G8J    6G8K    6G8L    6G8P    6G8Q    6GHP    6HHP    6HKB    6HKF    6HMT    6HMU    6HN2    6NV2    6QDR    6QDS    6QDT    6QDU    6QHL    6QHM    6QIU    6QZR    6QZS    6R5L    6RHC    6RJL    6RJQ    6RJZ    6RK8    6RKI    6RKK    6RKM    6RL3    6RL4    6RL6    6RM5    6RM7    6RP6    6RWH    6RWI    6RWS    6RWU    6RX2    6S39    6S3C    6S40    6S9Q    6SIN    6SIO    6SIP    6SIQ    6SLV    6SLW    6SLX    6TCH    6TJM    6TL3    6TLF    6TLG    6TM7    6TWZ    6W0L    6XWD    6Y1J    6Y3M    6Y3O    6Y3R    6Y3S    6Y3V    6Y40    6Y44    6Y8A    6Y8B    6Y8D    6Y8E    6YOW    6YOX    6YOY    6YP2    6YP3    6YP8    6YPL    6YPY    6YQ2    7AEW   
SuperfamilyP31947
AlphaFold pdb e-kbP31947   
Human Protein Atlas [tissue]ENSG00000175793-SFN [tissue]
HPRD03185
Protein Interaction databases
DIP (DOE-UCLA)P31947
IntAct (EBI)P31947
BioGRIDSFN
STRING (EMBL)SFN
ZODIACSFN
Ontologies - Pathways
QuickGOP31947
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  release of cytochrome c from mitochondria  keratinocyte development  protein binding  extracellular space  nucleus  mitochondrion  cytosol  cytosol  negative regulation of protein kinase activity  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  signal transduction  protein kinase C inhibitor activity  intrinsic apoptotic signaling pathway in response to DNA damage  regulation of epidermal cell division  negative regulation of keratinocyte proliferation  protein kinase binding  positive regulation of cell growth  keratinization  identical protein binding  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  cadherin binding  positive regulation of epidermal cell differentiation  positive regulation of protein export from nucleus  phosphoprotein binding  establishment of skin barrier  extracellular exosome  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  release of cytochrome c from mitochondria  keratinocyte development  protein binding  extracellular space  nucleus  mitochondrion  cytosol  cytosol  negative regulation of protein kinase activity  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  signal transduction  protein kinase C inhibitor activity  intrinsic apoptotic signaling pathway in response to DNA damage  regulation of epidermal cell division  negative regulation of keratinocyte proliferation  protein kinase binding  positive regulation of cell growth  keratinization  identical protein binding  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  cadherin binding  positive regulation of epidermal cell differentiation  positive regulation of protein export from nucleus  phosphoprotein binding  establishment of skin barrier  extracellular exosome  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Pathways : BIOCARTAEstrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes]   
Pathways : KEGGCell cycle    p53 signaling pathway    Aldosterone-regulated sodium reabsorption   
NDEx NetworkSFN
Atlas of Cancer Signalling NetworkSFN
Wikipedia pathwaysSFN
Orthology - Evolution
OrthoDB2810
GeneTree (enSembl)ENSG00000175793
Phylogenetic Trees/Animal Genes : TreeFamSFN
Homologs : HomoloGeneSFN
Homology/Alignments : Family Browser (UCSC)SFN
Gene fusions - Rearrangements
Fusion : MitelmanNUMA1/SFN [11q13.4/1p36.11]  
Fusion : MitelmanPRRC2A/SFN [6p21.33/1p36.11]  
Fusion : MitelmanSFN/ELK3 [1p36.11/12q23.1]  
Fusion : QuiverSFN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSFN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SFN
dbVarSFN
ClinVarSFN
MonarchSFN
1000_GenomesSFN 
Exome Variant ServerSFN
GNOMAD BrowserENSG00000175793
Varsome BrowserSFN
ACMGSFN variants
VarityP31947
Genomic Variants (DGV)SFN [DGVbeta]
DECIPHERSFN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSFN 
Mutations
ICGC Data PortalSFN 
TCGA Data PortalSFN 
Broad Tumor PortalSFN
OASIS PortalSFN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSFN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSFN
Mutations and Diseases : HGMDSFN
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSFN
DgiDB (Drug Gene Interaction Database)SFN
DoCM (Curated mutations)SFN
CIViC (Clinical Interpretations of Variants in Cancer)SFN
Cancer3DSFN
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601290   
Orphanet
DisGeNETSFN
MedgenSFN
Genetic Testing Registry SFN
NextProtP31947 [Medical]
GENETestsSFN
Target ValidationSFN
Huge Navigator SFN [HugePedia]
ClinGenSFN
Clinical trials, drugs, therapy
MyCancerGenomeSFN
Protein Interactions : CTDSFN
Pharm GKB GenePA177
PharosP31947
Clinical trialSFN
Miscellaneous
canSAR (ICR)SFN
HarmonizomeSFN
DataMed IndexSFN
Probes
Litterature
PubMed253 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSFN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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