Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SFRP1 (secreted frizzled related protein 1)

Identity

Alias_symbol (synonym)SARP2
FRP
FRP-1
Other aliasFRP1
FrzA
HGNC (Hugo) SFRP1
LocusID (NCBI) 6422
Atlas_Id 42276
Location 8p11.21  [Link to chromosome band 8p11]
Location_base_pair Starts at 41261957 and ends at 41309471 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RNF170 (8p11.21) / SFRP1 (8p11.21)SFRP1 (8p11.21) / ARMC5 (16p11.2)THAP1 (8p11.21) / SFRP1 (8p11.21)
YWHAQ (2p25.1) / SFRP1 (8p11.21)RNF170 8p11.21 / SFRP1 8p11.21SFRP1 8p11.21 / ARMC5 16p11.2
THAP1 8p11.21 / SFRP1 8p11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SFRP1   10776
Cards
Entrez_Gene (NCBI)SFRP1  6422  secreted frizzled related protein 1
AliasesFRP; FRP-1; FRP1; FrzA; 
SARP2
GeneCards (Weizmann)SFRP1
Ensembl hg19 (Hinxton)ENSG00000104332 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104332 [Gene_View]  chr8:41261957-41309471 [Contig_View]  SFRP1 [Vega]
ICGC DataPortalENSG00000104332
TCGA cBioPortalSFRP1
AceView (NCBI)SFRP1
Genatlas (Paris)SFRP1
WikiGenes6422
SOURCE (Princeton)SFRP1
Genetics Home Reference (NIH)SFRP1
Genomic and cartography
GoldenPath hg38 (UCSC)SFRP1  -     chr8:41261957-41309471 -  8p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SFRP1  -     8p11.21   [Description]    (hg19-Feb_2009)
EnsemblSFRP1 - 8p11.21 [CytoView hg19]  SFRP1 - 8p11.21 [CytoView hg38]
Mapping of homologs : NCBISFRP1 [Mapview hg19]  SFRP1 [Mapview hg38]
OMIM604156   
Gene and transcription
Genbank (Entrez)AF001900 AF017987 AF056087 AK127331 AK293090
RefSeq transcript (Entrez)NM_003012
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SFRP1
Cluster EST : UnigeneHs.213424 [ NCBI ]
CGAP (NCI)Hs.213424
Alternative Splicing GalleryENSG00000104332
Gene ExpressionSFRP1 [ NCBI-GEO ]   SFRP1 [ EBI - ARRAY_EXPRESS ]   SFRP1 [ SEEK ]   SFRP1 [ MEM ]
Gene Expression Viewer (FireBrowse)SFRP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6422
GTEX Portal (Tissue expression)SFRP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N474   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N474  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N474
Splice isoforms : SwissVarQ8N474
PhosPhoSitePlusQ8N474
Domaine pattern : Prosite (Expaxy)FZ (PS50038)    NTR (PS50189)   
Domains : Interpro (EBI)Frizzled/SFRP    Frizzled_dom    Netrin_domain    Netrin_module_non-TIMP    SFRP1    TIMP-like_OB-fold   
Domain families : Pfam (Sanger)Fz (PF01392)    NTR (PF01759)   
Domain families : Pfam (NCBI)pfam01392    pfam01759   
Domain families : Smart (EMBL)C345C (SM00643)  FRI (SM00063)  
Conserved Domain (NCBI)SFRP1
DMDM Disease mutations6422
Blocks (Seattle)SFRP1
SuperfamilyQ8N474
Human Protein AtlasENSG00000104332
Peptide AtlasQ8N474
HPRD09165
IPIIPI00749245   IPI00384783   
Protein Interaction databases
DIP (DOE-UCLA)Q8N474
IntAct (EBI)Q8N474
FunCoupENSG00000104332
BioGRIDSFRP1
STRING (EMBL)SFRP1
ZODIACSFRP1
Ontologies - Pathways
QuickGOQ8N474
Ontology : AmiGOosteoblast differentiation  ureteric bud development  positive regulation of cell-matrix adhesion  hematopoietic progenitor cell differentiation  cysteine-type endopeptidase activity  frizzled binding  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  intracellular  cytosol  plasma membrane  proteolysis  drug binding  heparin binding  positive regulation of cell proliferation  negative regulation of cell proliferation  male gonad development  female gonad development  cellular response to starvation  dorsal/ventral axis specification  cell surface  regulation of cell cycle process  negative regulation of gene expression  negative regulation of epithelial to mesenchymal transition  regulation of neuron projection development  neural crest cell fate commitment  response to organic cyclic compound  Wnt-protein binding  Wnt-protein binding  Wnt-protein binding  menstrual cycle phase  positive regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of ossification  negative regulation of ossification  positive regulation of cell growth  negative regulation of cell growth  negative regulation of cell migration  negative regulation of BMP signaling pathway  extracellular matrix  extracellular matrix  negative regulation of osteoblast proliferation  somatic stem cell population maintenance  response to drug  identical protein binding  positive regulation of apoptotic process  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of JUN kinase activity  positive regulation of GTPase activity  cellular response to fibroblast growth factor stimulus  stromal-epithelial cell signaling involved in prostate gland development  negative regulation of B cell differentiation  positive regulation of fat cell differentiation  negative regulation of osteoblast differentiation  negative regulation of osteoclast differentiation  regulation of angiogenesis  positive regulation of smoothened signaling pathway  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  negative regulation of insulin secretion  negative regulation of bone remodeling  negative regulation of fibroblast proliferation  digestive tract morphogenesis  positive regulation of epithelial cell proliferation  negative regulation of epithelial cell proliferation  negative regulation of peptidyl-tyrosine phosphorylation  positive regulation of stress fiber assembly  positive regulation of focal adhesion assembly  canonical Wnt signaling pathway  hematopoietic stem cell differentiation  bone trabecula formation  prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  regulation of branching involved in prostate gland morphogenesis  negative regulation of androgen receptor signaling pathway  extracellular exosome  cellular response to vitamin D  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to growth factor stimulus  cellular response to prostaglandin E stimulus  cellular response to estrogen stimulus  cellular response to estradiol stimulus  cellular response to hypoxia  cellular response to X-ray  cellular response to heparin  dopaminergic neuron differentiation  cellular response to transforming growth factor beta stimulus  cellular response to BMP stimulus  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  planar cell polarity pathway involved in neural tube closure  Wnt signaling pathway involved in somitogenesis  convergent extension involved in somitogenesis  positive regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  regulation of midbrain dopaminergic neuron differentiation  negative regulation of planar cell polarity pathway involved in axis elongation  positive regulation of non-canonical Wnt signaling pathway  negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification  negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation  negative regulation of fibroblast apoptotic process  positive regulation of fibroblast apoptotic process  
Ontology : EGO-EBIosteoblast differentiation  ureteric bud development  positive regulation of cell-matrix adhesion  hematopoietic progenitor cell differentiation  cysteine-type endopeptidase activity  frizzled binding  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  intracellular  cytosol  plasma membrane  proteolysis  drug binding  heparin binding  positive regulation of cell proliferation  negative regulation of cell proliferation  male gonad development  female gonad development  cellular response to starvation  dorsal/ventral axis specification  cell surface  regulation of cell cycle process  negative regulation of gene expression  negative regulation of epithelial to mesenchymal transition  regulation of neuron projection development  neural crest cell fate commitment  response to organic cyclic compound  Wnt-protein binding  Wnt-protein binding  Wnt-protein binding  menstrual cycle phase  positive regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of Wnt signaling pathway  negative regulation of ossification  negative regulation of ossification  positive regulation of cell growth  negative regulation of cell growth  negative regulation of cell migration  negative regulation of BMP signaling pathway  extracellular matrix  extracellular matrix  negative regulation of osteoblast proliferation  somatic stem cell population maintenance  response to drug  identical protein binding  positive regulation of apoptotic process  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of JUN kinase activity  positive regulation of GTPase activity  cellular response to fibroblast growth factor stimulus  stromal-epithelial cell signaling involved in prostate gland development  negative regulation of B cell differentiation  positive regulation of fat cell differentiation  negative regulation of osteoblast differentiation  negative regulation of osteoclast differentiation  regulation of angiogenesis  positive regulation of smoothened signaling pathway  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  negative regulation of insulin secretion  negative regulation of bone remodeling  negative regulation of fibroblast proliferation  digestive tract morphogenesis  positive regulation of epithelial cell proliferation  negative regulation of epithelial cell proliferation  negative regulation of peptidyl-tyrosine phosphorylation  positive regulation of stress fiber assembly  positive regulation of focal adhesion assembly  canonical Wnt signaling pathway  hematopoietic stem cell differentiation  bone trabecula formation  prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  regulation of branching involved in prostate gland morphogenesis  negative regulation of androgen receptor signaling pathway  extracellular exosome  cellular response to vitamin D  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to growth factor stimulus  cellular response to prostaglandin E stimulus  cellular response to estrogen stimulus  cellular response to estradiol stimulus  cellular response to hypoxia  cellular response to X-ray  cellular response to heparin  dopaminergic neuron differentiation  cellular response to transforming growth factor beta stimulus  cellular response to BMP stimulus  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  planar cell polarity pathway involved in neural tube closure  Wnt signaling pathway involved in somitogenesis  convergent extension involved in somitogenesis  positive regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  regulation of midbrain dopaminergic neuron differentiation  negative regulation of planar cell polarity pathway involved in axis elongation  positive regulation of non-canonical Wnt signaling pathway  negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification  negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation  negative regulation of fibroblast apoptotic process  positive regulation of fibroblast apoptotic process  
Pathways : KEGGWnt signaling pathway   
NDEx NetworkSFRP1
Atlas of Cancer Signalling NetworkSFRP1
Wikipedia pathwaysSFRP1
Orthology - Evolution
OrthoDB6422
GeneTree (enSembl)ENSG00000104332
Phylogenetic Trees/Animal Genes : TreeFamSFRP1
HOVERGENQ8N474
HOGENOMQ8N474
Homologs : HomoloGeneSFRP1
Homology/Alignments : Family Browser (UCSC)SFRP1
Gene fusions - Rearrangements
Fusion : MitelmanRNF170/SFRP1 [8p11.21/8p11.21]  [t(8;8)(p11;p11)]  
Fusion : MitelmanSFRP1/ARMC5 [8p11.21/16p11.2]  [t(8;16)(p11;p11)]  
Fusion : MitelmanTHAP1/SFRP1 [8p11.21/8p11.21]  [t(8;8)(p11;p11)]  
Fusion: TCGARNF170 8p11.21 SFRP1 8p11.21 LUAD
Fusion: TCGASFRP1 8p11.21 ARMC5 16p11.2 BRCA
Fusion: TCGATHAP1 8p11.21 SFRP1 8p11.21 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSFRP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SFRP1
dbVarSFRP1
ClinVarSFRP1
1000_GenomesSFRP1 
Exome Variant ServerSFRP1
ExAC (Exome Aggregation Consortium)SFRP1 (select the gene name)
Genetic variants : HAPMAP6422
Genomic Variants (DGV)SFRP1 [DGVbeta]
DECIPHERSFRP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSFRP1 
Mutations
ICGC Data PortalSFRP1 
TCGA Data PortalSFRP1 
Broad Tumor PortalSFRP1
OASIS PortalSFRP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSFRP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSFRP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SFRP1
DgiDB (Drug Gene Interaction Database)SFRP1
DoCM (Curated mutations)SFRP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SFRP1 (select a term)
intoGenSFRP1
Cancer3DSFRP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604156   
Orphanet
MedgenSFRP1
Genetic Testing Registry SFRP1
NextProtQ8N474 [Medical]
TSGene6422
GENETestsSFRP1
Target ValidationSFRP1
Huge Navigator SFRP1 [HugePedia]
snp3D : Map Gene to Disease6422
BioCentury BCIQSFRP1
ClinGenSFRP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6422
Chemical/Pharm GKB GenePA35692
Clinical trialSFRP1
Miscellaneous
canSAR (ICR)SFRP1 (select the gene name)
Probes
Litterature
PubMed169 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSFRP1
EVEXSFRP1
GoPubMedSFRP1
iHOPSFRP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:55:14 CEST 2017

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