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SFRP5 (secreted frizzled related protein 5)

Identity

Alias_symbol (synonym)SARP3
Other alias
HGNC (Hugo) SFRP5
LocusID (NCBI) 6425
Atlas_Id 42278
Location 10q24.2  [Link to chromosome band 10q24]
Location_base_pair Starts at 97766751 and ends at 97771999 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SLIT1 (10q24.1) / SFRP5 (10q24.2)SLIT1 10q24.1 / SFRP5 10q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SFRP5   10779
Cards
Entrez_Gene (NCBI)SFRP5  6425  secreted frizzled related protein 5
AliasesSARP3
GeneCards (Weizmann)SFRP5
Ensembl hg19 (Hinxton)ENSG00000120057 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120057 [Gene_View]  chr10:97766751-97771999 [Contig_View]  SFRP5 [Vega]
ICGC DataPortalENSG00000120057
TCGA cBioPortalSFRP5
AceView (NCBI)SFRP5
Genatlas (Paris)SFRP5
WikiGenes6425
SOURCE (Princeton)SFRP5
Genetics Home Reference (NIH)SFRP5
Genomic and cartography
GoldenPath hg38 (UCSC)SFRP5  -     chr10:97766751-97771999 -  10q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SFRP5  -     10q24.2   [Description]    (hg19-Feb_2009)
EnsemblSFRP5 - 10q24.2 [CytoView hg19]  SFRP5 - 10q24.2 [CytoView hg38]
Mapping of homologs : NCBISFRP5 [Mapview hg19]  SFRP5 [Mapview hg38]
OMIM604158   
Gene and transcription
Genbank (Entrez)AF017988 AF117758 BC050435
RefSeq transcript (Entrez)NM_003015
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SFRP5
Cluster EST : UnigeneHs.279565 [ NCBI ]
CGAP (NCI)Hs.279565
Alternative Splicing GalleryENSG00000120057
Gene ExpressionSFRP5 [ NCBI-GEO ]   SFRP5 [ EBI - ARRAY_EXPRESS ]   SFRP5 [ SEEK ]   SFRP5 [ MEM ]
Gene Expression Viewer (FireBrowse)SFRP5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6425
GTEX Portal (Tissue expression)SFRP5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5T4F7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5T4F7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5T4F7
Splice isoforms : SwissVarQ5T4F7
PhosPhoSitePlusQ5T4F7
Domaine pattern : Prosite (Expaxy)FZ (PS50038)    NTR (PS50189)   
Domains : Interpro (EBI)Frizzled/SFRP    Frizzled_dom    Netrin_domain    Netrin_module_non-TIMP    TIMP-like_OB-fold   
Domain families : Pfam (Sanger)Fz (PF01392)    NTR (PF01759)   
Domain families : Pfam (NCBI)pfam01392    pfam01759   
Domain families : Smart (EMBL)C345C (SM00643)  FRI (SM00063)  
Conserved Domain (NCBI)SFRP5
DMDM Disease mutations6425
Blocks (Seattle)SFRP5
SuperfamilyQ5T4F7
Human Protein AtlasENSG00000120057
Peptide AtlasQ5T4F7
HPRD09166
IPIIPI00017558   
Protein Interaction databases
DIP (DOE-UCLA)Q5T4F7
IntAct (EBI)Q5T4F7
FunCoupENSG00000120057
BioGRIDSFRP5
STRING (EMBL)SFRP5
ZODIACSFRP5
Ontologies - Pathways
QuickGOQ5T4F7
Ontology : AmiGOextracellular space  apoptotic process  establishment or maintenance of cell polarity  signal transduction  multicellular organism development  visual perception  negative regulation of cell proliferation  anatomical structure morphogenesis  Wnt signaling pathway  Wnt-protein binding  cell differentiation  negative regulation of Wnt signaling pathway  negative regulation of catenin import into nucleus  negative regulation of sequence-specific DNA binding transcription factor activity  negative regulation of protein kinase B signaling  negative regulation of canonical Wnt signaling pathway  negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis  
Ontology : EGO-EBIextracellular space  apoptotic process  establishment or maintenance of cell polarity  signal transduction  multicellular organism development  visual perception  negative regulation of cell proliferation  anatomical structure morphogenesis  Wnt signaling pathway  Wnt-protein binding  cell differentiation  negative regulation of Wnt signaling pathway  negative regulation of catenin import into nucleus  negative regulation of sequence-specific DNA binding transcription factor activity  negative regulation of protein kinase B signaling  negative regulation of canonical Wnt signaling pathway  negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis  
Pathways : KEGGWnt signaling pathway   
NDEx NetworkSFRP5
Atlas of Cancer Signalling NetworkSFRP5
Wikipedia pathwaysSFRP5
Orthology - Evolution
OrthoDB6425
GeneTree (enSembl)ENSG00000120057
Phylogenetic Trees/Animal Genes : TreeFamSFRP5
HOVERGENQ5T4F7
HOGENOMQ5T4F7
Homologs : HomoloGeneSFRP5
Homology/Alignments : Family Browser (UCSC)SFRP5
Gene fusions - Rearrangements
Fusion : MitelmanSLIT1/SFRP5 [10q24.1/10q24.2]  [t(10;10)(q24;q24)]  
Fusion: TCGASLIT1 10q24.1 SFRP5 10q24.2 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSFRP5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SFRP5
dbVarSFRP5
ClinVarSFRP5
1000_GenomesSFRP5 
Exome Variant ServerSFRP5
ExAC (Exome Aggregation Consortium)SFRP5 (select the gene name)
Genetic variants : HAPMAP6425
Genomic Variants (DGV)SFRP5 [DGVbeta]
DECIPHERSFRP5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSFRP5 
Mutations
ICGC Data PortalSFRP5 
TCGA Data PortalSFRP5 
Broad Tumor PortalSFRP5
OASIS PortalSFRP5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSFRP5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSFRP5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SFRP5
DgiDB (Drug Gene Interaction Database)SFRP5
DoCM (Curated mutations)SFRP5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SFRP5 (select a term)
intoGenSFRP5
Cancer3DSFRP5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604158   
Orphanet
MedgenSFRP5
Genetic Testing Registry SFRP5
NextProtQ5T4F7 [Medical]
TSGene6425
GENETestsSFRP5
Target ValidationSFRP5
Huge Navigator SFRP5 [HugePedia]
snp3D : Map Gene to Disease6425
BioCentury BCIQSFRP5
ClinGenSFRP5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6425
Chemical/Pharm GKB GenePA35695
Clinical trialSFRP5
Miscellaneous
canSAR (ICR)SFRP5 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSFRP5
EVEXSFRP5
GoPubMedSFRP5
iHOPSFRP5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:07:08 CEST 2017

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