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SFTPA2 (surfactant protein A2)

Identity

Alias_namespulmonary-associated protein A2A
Alias_symbol (synonym)SP-A2
COLEC5
Other aliasPSAP
PSP-A
PSPA
SFTP1
SFTPA2B
SP-2A
SP-A
SPA2
SPAII
HGNC (Hugo) SFTPA2
LocusID (NCBI) 729238
Atlas_Id 50697
Location 10q22.3  [Link to chromosome band 10q22]
Location_base_pair Starts at 79555852 and ends at 79560461 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AGER (6p21.32) / SFTPA2 (10q22.3)FTL (19q13.33) / SFTPA2 (10q22.3)SFTPA2 (10q22.3) / MMP14 (14q11.2)
SFTPA2 (10q22.3) / SFTPB (2p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)SFTPA2   10799
Cards
Entrez_Gene (NCBI)SFTPA2  729238  surfactant protein A2
AliasesCOLEC5; PSAP; PSP-A; PSPA; 
SFTP1; SFTPA2B; SP-2A; SP-A; SPA2; SPAII
GeneCards (Weizmann)SFTPA2
Ensembl hg19 (Hinxton)ENSG00000185303 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185303 [Gene_View]  chr10:79555852-79560461 [Contig_View]  SFTPA2 [Vega]
ICGC DataPortalENSG00000185303
TCGA cBioPortalSFTPA2
AceView (NCBI)SFTPA2
Genatlas (Paris)SFTPA2
WikiGenes729238
SOURCE (Princeton)SFTPA2
Genetics Home Reference (NIH)SFTPA2
Genomic and cartography
GoldenPath hg38 (UCSC)SFTPA2  -     chr10:79555852-79560461 -  10q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SFTPA2  -     10q22.3   [Description]    (hg19-Feb_2009)
EnsemblSFTPA2 - 10q22.3 [CytoView hg19]  SFTPA2 - 10q22.3 [CytoView hg38]
Mapping of homologs : NCBISFTPA2 [Mapview hg19]  SFTPA2 [Mapview hg38]
OMIM178500   178642   
Gene and transcription
Genbank (Entrez)AK225599 AK298041 AK298074 AK298114 AK313179
RefSeq transcript (Entrez)NM_001098668 NM_001320813 NM_001320814
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SFTPA2
Cluster EST : UnigeneHs.523084 [ NCBI ]
CGAP (NCI)Hs.523084
Alternative Splicing GalleryENSG00000185303
Gene ExpressionSFTPA2 [ NCBI-GEO ]   SFTPA2 [ EBI - ARRAY_EXPRESS ]   SFTPA2 [ SEEK ]   SFTPA2 [ MEM ]
Gene Expression Viewer (FireBrowse)SFTPA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)729238
GTEX Portal (Tissue expression)SFTPA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IWL1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IWL1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IWL1
Splice isoforms : SwissVarQ8IWL1
PhosPhoSitePlusQ8IWL1
Domaine pattern : Prosite (Expaxy)C_TYPE_LECTIN_1 (PS00615)    C_TYPE_LECTIN_2 (PS50041)   
Domains : Interpro (EBI)C-type_lectin-like    C-type_lectin-like/link    C-type_lectin_CS    Collectin_CTLD    CTDL_fold   
Domain families : Pfam (Sanger)Lectin_C (PF00059)   
Domain families : Pfam (NCBI)pfam00059   
Domain families : Smart (EMBL)CLECT (SM00034)  
Conserved Domain (NCBI)SFTPA2
DMDM Disease mutations729238
Blocks (Seattle)SFTPA2
SuperfamilyQ8IWL1
Human Protein AtlasENSG00000185303
Peptide AtlasQ8IWL1
IPIIPI00293120   IPI00953674   IPI01012889   IPI00953130   IPI00647745   
Protein Interaction databases
DIP (DOE-UCLA)Q8IWL1
IntAct (EBI)Q8IWL1
FunCoupENSG00000185303
BioGRIDSFTPA2
STRING (EMBL)SFTPA2
ZODIACSFTPA2
Ontologies - Pathways
QuickGOQ8IWL1
Ontology : AmiGOtoll-like receptor signaling pathway  extracellular region  proteinaceous extracellular matrix  collagen trimer  extracellular space  endoplasmic reticulum membrane  respiratory gaseous exchange  carbohydrate binding  lamellar body  cellular protein metabolic process  clathrin-coated endocytic vesicle  
Ontology : EGO-EBItoll-like receptor signaling pathway  extracellular region  proteinaceous extracellular matrix  collagen trimer  extracellular space  endoplasmic reticulum membrane  respiratory gaseous exchange  carbohydrate binding  lamellar body  cellular protein metabolic process  clathrin-coated endocytic vesicle  
Pathways : KEGGPhagosome    Pertussis   
NDEx NetworkSFTPA2
Atlas of Cancer Signalling NetworkSFTPA2
Wikipedia pathwaysSFTPA2
Orthology - Evolution
OrthoDB729238
GeneTree (enSembl)ENSG00000185303
Phylogenetic Trees/Animal Genes : TreeFamSFTPA2
HOVERGENQ8IWL1
HOGENOMQ8IWL1
Homologs : HomoloGeneSFTPA2
Homology/Alignments : Family Browser (UCSC)SFTPA2
Gene fusions - Rearrangements
Fusion : MitelmanFTL/SFTPA2 [19q13.33/10q22.3]  [t(10;19)(q22;q13)]  
Fusion : MitelmanSFTPA2/SFTPB [10q22.3/2p11.2]  [t(2;10)(p11;q22)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSFTPA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SFTPA2
dbVarSFTPA2
ClinVarSFTPA2
1000_GenomesSFTPA2 
Exome Variant ServerSFTPA2
ExAC (Exome Aggregation Consortium)SFTPA2 (select the gene name)
Genetic variants : HAPMAP729238
Genomic Variants (DGV)SFTPA2 [DGVbeta]
DECIPHERSFTPA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSFTPA2 
Mutations
ICGC Data PortalSFTPA2 
TCGA Data PortalSFTPA2 
Broad Tumor PortalSFTPA2
OASIS PortalSFTPA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSFTPA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSFTPA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch SFTPA2
DgiDB (Drug Gene Interaction Database)SFTPA2
DoCM (Curated mutations)SFTPA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SFTPA2 (select a term)
intoGenSFTPA2
Cancer3DSFTPA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM178500    178642   
Orphanet7029   
MedgenSFTPA2
Genetic Testing Registry SFTPA2
NextProtQ8IWL1 [Medical]
TSGene729238
GENETestsSFTPA2
Target ValidationSFTPA2
Huge Navigator SFTPA2 [HugePedia]
snp3D : Map Gene to Disease729238
BioCentury BCIQSFTPA2
ClinGenSFTPA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD729238
Chemical/Pharm GKB GenePA35711
Clinical trialSFTPA2
Miscellaneous
canSAR (ICR)SFTPA2 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSFTPA2
EVEXSFTPA2
GoPubMedSFTPA2
iHOPSFTPA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:30:49 CEST 2017

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