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SFTPB (surfactant protein B)

Identity

Alias_namesSFTP3
surfactant
Alias_symbol (synonym)SP-B
Other aliasPSP-B
SFTB3
SMDP1
HGNC (Hugo) SFTPB
LocusID (NCBI) 6439
Atlas_Id 54615
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 85884440 and ends at 85895864 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACTR3C (7q36.1) / SFTPB (2p11.2)BAG3 (10q26.11) / SFTPB (2p11.2)DNAH2 (17p13.1) / SFTPB (2p11.2)
DPYSL3 (5q32) / SFTPB (2p11.2)EML3 (11q12.3) / SFTPB (2p11.2)EPOR (19p13.2) / SFTPB (2p11.2)
FAM53B (10q26.13) / SFTPB (2p11.2)GRN (17q21.31) / SFTPB (2p11.2)KCNK2 (1q41) / SFTPB (2p11.2)
KHNYN (14q12) / SFTPB (2p11.2)LARP6 (15q23) / SFTPB (2p11.2)LYST (1q42.3) / SFTPB (2p11.2)
NEUROD2 (17q12) / SFTPB (2p11.2)ODF3L1 (15q24.2) / SFTPB (2p11.2)SFTPA2 (10q22.3) / SFTPB (2p11.2)
SFTPB (2p11.2) / AK3 (9p24.1)SFTPB (2p11.2) / AMOTL2 (3q22.2)SFTPB (2p11.2) / DPYSL2 (8p21.2)
SFTPB (2p11.2) / ERP27 (12p12.3)SFTPB (2p11.2) / FKBP9 (7p14.3)SFTPB (2p11.2) / FOXP2 (7q31.1)
SFTPB (2p11.2) / HMGB3 (Xq28)SFTPB (2p11.2) / HNF4A (20q13.12)SFTPB (2p11.2) / LOC284798 (20p11.21)
SFTPB (2p11.2) / LPP (3q28)SFTPB (2p11.2) / MPC1 (6q27)SFTPB (2p11.2) / MSN (Xq12)
SFTPB (2p11.2) / NCOA5 (20q13.12)SFTPB (2p11.2) / NFKBIZ (3q12.3)SFTPB (2p11.2) / RPS6KA2 (6q27)
SFTPB (2p11.2) / SFTPB (2p11.2)SFTPB (2p11.2) / SNRPC (6p21.31)SFTPB (2p11.2) / SOX30 (5q33.3)
SFTPB (2p11.2) / TPT1 (13q14.13)SLC25A24 (1p13.3) / SFTPB (2p11.2)SRSF10 (1p36.11) / SFTPB (2p11.2)
STARD9 (15q15.2) / SFTPB (2p11.2)UBA2 (19q13.11) / SFTPB (2p11.2)WFIKKN2 (17q21.33) / SFTPB (2p11.2)
ZNF281 (1q32.1) / SFTPB (2p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)SFTPB   10801
Cards
Entrez_Gene (NCBI)SFTPB  6439  surfactant protein B
AliasesPSP-B; SFTB3; SFTP3; SMDP1; 
SP-B
GeneCards (Weizmann)SFTPB
Ensembl hg19 (Hinxton)ENSG00000168878 [Gene_View]  chr2:85884440-85895864 [Contig_View]  SFTPB [Vega]
Ensembl hg38 (Hinxton)ENSG00000168878 [Gene_View]  chr2:85884440-85895864 [Contig_View]  SFTPB [Vega]
ICGC DataPortalENSG00000168878
TCGA cBioPortalSFTPB
AceView (NCBI)SFTPB
Genatlas (Paris)SFTPB
WikiGenes6439
SOURCE (Princeton)SFTPB
Genetics Home Reference (NIH)SFTPB
Genomic and cartography
GoldenPath hg19 (UCSC)SFTPB  -     chr2:85884440-85895864 -  2p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SFTPB  -     2p11.2   [Description]    (hg38-Dec_2013)
EnsemblSFTPB - 2p11.2 [CytoView hg19]  SFTPB - 2p11.2 [CytoView hg38]
Mapping of homologs : NCBISFTPB [Mapview hg19]  SFTPB [Mapview hg38]
OMIM178640   265120   
Gene and transcription
Genbank (Entrez)AB439563 AB439564 AB439565 AB439566 AK303817
RefSeq transcript (Entrez)NM_000542 NM_198843
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_016967 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)SFTPB
Cluster EST : UnigeneHs.512690 [ NCBI ]
CGAP (NCI)Hs.512690
Alternative Splicing GalleryENSG00000168878
Gene ExpressionSFTPB [ NCBI-GEO ]   SFTPB [ EBI - ARRAY_EXPRESS ]   SFTPB [ SEEK ]   SFTPB [ MEM ]
Gene Expression Viewer (FireBrowse)SFTPB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6439
GTEX Portal (Tissue expression)SFTPB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07988   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07988  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07988
Splice isoforms : SwissVarP07988
PhosPhoSitePlusP07988
Domaine pattern : Prosite (Expaxy)SAP_A (PS51110)    SAP_B (PS50015)   
Domains : Interpro (EBI)SAP_A    SapB_1    SapB_2    Saposin    Saposin-like    SaposinB_dom   
Domain families : Pfam (Sanger)SapA (PF02199)    SapB_1 (PF05184)    SapB_2 (PF03489)   
Domain families : Pfam (NCBI)pfam02199    pfam05184    pfam03489   
Domain families : Smart (EMBL)SAPA (SM00162)  SapB (SM00741)  
Conserved Domain (NCBI)SFTPB
DMDM Disease mutations6439
Blocks (Seattle)SFTPB
PDB (SRS)1DFW    1KMR    1RG3    1RG4    1SSZ    2DWF    2JOU    2M0H    2M1T   
PDB (PDBSum)1DFW    1KMR    1RG3    1RG4    1SSZ    2DWF    2JOU    2M0H    2M1T   
PDB (IMB)1DFW    1KMR    1RG3    1RG4    1SSZ    2DWF    2JOU    2M0H    2M1T   
PDB (RSDB)1DFW    1KMR    1RG3    1RG4    1SSZ    2DWF    2JOU    2M0H    2M1T   
Structural Biology KnowledgeBase1DFW    1KMR    1RG3    1RG4    1SSZ    2DWF    2JOU    2M0H    2M1T   
SCOP (Structural Classification of Proteins)1DFW    1KMR    1RG3    1RG4    1SSZ    2DWF    2JOU    2M0H    2M1T   
CATH (Classification of proteins structures)1DFW    1KMR    1RG3    1RG4    1SSZ    2DWF    2JOU    2M0H    2M1T   
SuperfamilyP07988
Human Protein AtlasENSG00000168878
Peptide AtlasP07988
HPRD01523
IPIIPI00296083   IPI00910268   IPI00915806   IPI01013812   
Protein Interaction databases
DIP (DOE-UCLA)P07988
IntAct (EBI)P07988
FunCoupENSG00000168878
BioGRIDSFTPB
STRING (EMBL)SFTPB
ZODIACSFTPB
Ontologies - Pathways
QuickGOP07988
Ontology : AmiGOG-protein coupled receptor binding  extracellular region  extracellular space  nucleoplasm  lysosome  multivesicular body  endoplasmic reticulum membrane  sphingolipid metabolic process  respiratory gaseous exchange  enzyme activator activity  organ morphogenesis  lamellar body  positive regulation of catalytic activity  cellular protein metabolic process  clathrin-coated endocytic vesicle  alveolar lamellar body  multivesicular body lumen  
Ontology : EGO-EBIG-protein coupled receptor binding  extracellular region  extracellular space  nucleoplasm  lysosome  multivesicular body  endoplasmic reticulum membrane  sphingolipid metabolic process  respiratory gaseous exchange  enzyme activator activity  organ morphogenesis  lamellar body  positive regulation of catalytic activity  cellular protein metabolic process  clathrin-coated endocytic vesicle  alveolar lamellar body  multivesicular body lumen  
NDEx NetworkSFTPB
Atlas of Cancer Signalling NetworkSFTPB
Wikipedia pathwaysSFTPB
Orthology - Evolution
OrthoDB6439
GeneTree (enSembl)ENSG00000168878
Phylogenetic Trees/Animal Genes : TreeFamSFTPB
HOVERGENP07988
HOGENOMP07988
Homologs : HomoloGeneSFTPB
Homology/Alignments : Family Browser (UCSC)SFTPB
Gene fusions - Rearrangements
Fusion : MitelmanSFTPA2/SFTPB [10q22.3/2p11.2]  [t(2;10)(p11;q22)]  
Fusion : MitelmanSFTPB/DPYSL2 [2p11.2/8p21.2]  [t(2;8)(p11;p21)]  
Fusion Cancer (Beijing)BAG3 [10q26.11]  -  SFTPB [2p11.2]  [FUSC003619]
Fusion Cancer (Beijing)DNAH2 [17p13.1]  -  SFTPB [2p11.2]  [FUSC003538]
Fusion Cancer (Beijing)EML3 [11q12.3]  -  SFTPB [2p11.2]  [FUSC002628]
Fusion Cancer (Beijing)EPOR [19p13.2]  -  SFTPB [2p11.2]  [FUSC003071]
Fusion Cancer (Beijing)FAM53B [10q26.13]  -  SFTPB [2p11.2]  [FUSC002990]
Fusion Cancer (Beijing)GRN [17q21.31]  -  SFTPB [2p11.2]  [FUSC002741]
Fusion Cancer (Beijing)KCNK2 [1q41]  -  SFTPB [2p11.2]  [FUSC003079]
Fusion Cancer (Beijing)KHNYN [14q12]  -  SFTPB [2p11.2]  [FUSC002998]
Fusion Cancer (Beijing)LARP6 [15q23]  -  SFTPB [2p11.2]  [FUSC003635]
Fusion Cancer (Beijing)NEUROD2 [17q12]  -  SFTPB [2p11.2]  [FUSC003644]  [FUSC003644]
Fusion Cancer (Beijing)ODF3L1 [15q24.2]  -  SFTPB [2p11.2]  [FUSC003647]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  AMOTL2 [3q22.2]  [FUSC003022]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  BRP44L [FUSC003396]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  FKBP9 [7p14.3]  [FUSC003300]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  FOXP2 [7q31.1]  [FUSC003657]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  HMGB3 [Xq28]  [FUSC003659]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  HNF4A [20q13.12]  [FUSC002436]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  LOC284798 [20p11.21]  [FUSC002776]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  LPP [3q28]  [FUSC002777]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  MSN [Xq12]  [FUSC003661]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  NCOA5 [20q13.12]  [FUSC003662]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  RPS6KA2 [6q27]  [FUSC003304]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  SNRPC [6p21.31]  [FUSC003275]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  SOX30 [5q33.3]  [FUSC003666]
Fusion Cancer (Beijing)SLC25A24 [1p13.3]  -  SFTPB [2p11.2]  [FUSC003669]
Fusion Cancer (Beijing)SRSF10 [1p36.11]  -  SFTPB [2p11.2]  [FUSC003117]
Fusion Cancer (Beijing)STARD9 [15q15.2]  -  SFTPB [2p11.2]  [FUSC003671]
Fusion Cancer (Beijing)UBA2 [19q13.11]  -  SFTPB [2p11.2]  [FUSC002787]
Fusion Cancer (Beijing)WFIKKN2 [17q21.33]  -  SFTPB [2p11.2]  [FUSC003045]
Fusion Cancer (Beijing)ZNF281 [1q32.1]  -  SFTPB [2p11.2]  [FUSC003310]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSFTPB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SFTPB
dbVarSFTPB
ClinVarSFTPB
1000_GenomesSFTPB 
Exome Variant ServerSFTPB
ExAC (Exome Aggregation Consortium)SFTPB (select the gene name)
Genetic variants : HAPMAP6439
Genomic Variants (DGV)SFTPB [DGVbeta]
DECIPHER (Syndromes)2:85884440-85895864  ENSG00000168878
CONAN: Copy Number AnalysisSFTPB 
Mutations
ICGC Data PortalSFTPB 
TCGA Data PortalSFTPB 
Broad Tumor PortalSFTPB
OASIS PortalSFTPB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSFTPB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSFTPB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SFTPB
DgiDB (Drug Gene Interaction Database)SFTPB
DoCM (Curated mutations)SFTPB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SFTPB (select a term)
intoGenSFTPB
Cancer3DSFTPB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM178640    265120   
Orphanet18862    10958   
MedgenSFTPB
Genetic Testing Registry SFTPB
NextProtP07988 [Medical]
TSGene6439
GENETestsSFTPB
Huge Navigator SFTPB [HugePedia]
snp3D : Map Gene to Disease6439
BioCentury BCIQSFTPB
ClinGenSFTPB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6439
Chemical/Pharm GKB GenePA35713
Clinical trialSFTPB
Miscellaneous
canSAR (ICR)SFTPB (select the gene name)
Probes
Litterature
PubMed128 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSFTPB
EVEXSFTPB
GoPubMedSFTPB
iHOPSFTPB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:19:05 CEST 2017

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