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SFTPB (surfactant protein B)

Identity

Alias (NCBI)PSP-B
SFTB3
SFTP3
SMDP1
SP-B
HGNC (Hugo) SFTPB
HGNC Alias symbSP-B
HGNC Previous nameSFTP3
HGNC Previous namesurfactant, pulmonary-associated protein B
LocusID (NCBI) 6439
Atlas_Id 54615
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 85657307 and ends at 85668741 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTR3C (7q36.1) / SFTPB (2p11.2)BAG3 (10q26.11) / SFTPB (2p11.2)DNAH2 (17p13.1) / SFTPB (2p11.2)
DPYSL3 (5q32) / SFTPB (2p11.2)EML3 (11q12.3) / SFTPB (2p11.2)EPOR (19p13.2) / SFTPB (2p11.2)
FAM53B (10q26.13) / SFTPB (2p11.2)GRN (17q21.31) / SFTPB (2p11.2)KCNK2 (1q41) / SFTPB (2p11.2)
KHNYN (14q12) / SFTPB (2p11.2)LARP6 (15q23) / SFTPB (2p11.2)LYST (1q42.3) / SFTPB (2p11.2)
NEUROD2 (17q12) / SFTPB (2p11.2)ODF3L1 (15q24.2) / SFTPB (2p11.2)SFTPA2 (10q22.3) / SFTPB (2p11.2)
SFTPB (2p11.2) / AK3 (9p24.1)SFTPB (2p11.2) / AMOTL2 (3q22.2)SFTPB (2p11.2) / DPYSL2 (8p21.2)
SFTPB (2p11.2) / ERP27 (12p12.3)SFTPB (2p11.2) / FKBP9 (7p14.3)SFTPB (2p11.2) / FOXP2 (7q31.1)
SFTPB (2p11.2) / HMGB3 (Xq28)SFTPB (2p11.2) / HNF4A (20q13.12)SFTPB (2p11.2) / LOC284798 (20p11.21)
SFTPB (2p11.2) / LPP (3q28)SFTPB (2p11.2) / MPC1 (6q27)SFTPB (2p11.2) / MSN (Xq12)
SFTPB (2p11.2) / NCOA5 (20q13.12)SFTPB (2p11.2) / NFKBIZ (3q12.3)SFTPB (2p11.2) / RPS6KA2 (6q27)
SFTPB (2p11.2) / SFTPB (2p11.2)SFTPB (2p11.2) / SNRPC (6p21.31)SFTPB (2p11.2) / SOX30 (5q33.3)
SFTPB (2p11.2) / TPT1 (13q14.13)SLC25A24 (1p13.3) / SFTPB (2p11.2)SRSF10 (1p36.11) / SFTPB (2p11.2)
STARD9 (15q15.2) / SFTPB (2p11.2)UBA2 (19q13.11) / SFTPB (2p11.2)WFIKKN2 (17q21.33) / SFTPB (2p11.2)
ZNF281 (1q32.1) / SFTPB (2p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SFTPB   10801
Cards
Entrez_Gene (NCBI)SFTPB    surfactant protein B
AliasesPSP-B; SFTB3; SFTP3; SMDP1; 
SP-B
GeneCards (Weizmann)SFTPB
Ensembl hg19 (Hinxton)ENSG00000168878 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168878 [Gene_View]  ENSG00000168878 [Sequence]  chr2:85657307-85668741 [Contig_View]  SFTPB [Vega]
ICGC DataPortalENSG00000168878
TCGA cBioPortalSFTPB
AceView (NCBI)SFTPB
Genatlas (Paris)SFTPB
SOURCE (Princeton)SFTPB
Genetics Home Reference (NIH)SFTPB
Genomic and cartography
GoldenPath hg38 (UCSC)SFTPB  -     chr2:85657307-85668741 -  2p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SFTPB  -     2p11.2   [Description]    (hg19-Feb_2009)
GoldenPathSFTPB - 2p11.2 [CytoView hg19]  SFTPB - 2p11.2 [CytoView hg38]
ImmunoBaseENSG00000168878
Genome Data Viewer NCBISFTPB [Mapview hg19]  
OMIM178640   265120   
Gene and transcription
Genbank (Entrez)AB439563 AB439564 AB439565 AB439566 AK303817
RefSeq transcript (Entrez)NM_000542 NM_001367281 NM_198843
Consensus coding sequences : CCDS (NCBI)SFTPB
Gene ExpressionSFTPB [ NCBI-GEO ]   SFTPB [ EBI - ARRAY_EXPRESS ]   SFTPB [ SEEK ]   SFTPB [ MEM ]
Gene Expression Viewer (FireBrowse)SFTPB [ Firebrowse - Broad ]
GenevisibleExpression of SFTPB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6439
GTEX Portal (Tissue expression)SFTPB
Human Protein AtlasENSG00000168878-SFTPB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07988   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07988  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07988
PhosPhoSitePlusP07988
Domaine pattern : Prosite (Expaxy)SAP_A (PS51110)    SAP_B (PS50015)   
Domains : Interpro (EBI)SAP_A    SapB_1    SapB_2    Saposin    Saposin-like    SaposinB_dom   
Domain families : Pfam (Sanger)SapA (PF02199)    SapB_1 (PF05184)    SapB_2 (PF03489)   
Domain families : Pfam (NCBI)pfam02199    pfam05184    pfam03489   
Domain families : Smart (EMBL)SAPA (SM00162)  SapB (SM00741)  
Conserved Domain (NCBI)SFTPB
PDB (RSDB)1DFW    1KMR    1RG3    1RG4    1SSZ    2DWF    2JOU    2M0H    2M1T   
PDB Europe1DFW    1KMR    1RG3    1RG4    1SSZ    2DWF    2JOU    2M0H    2M1T   
PDB (PDBSum)1DFW    1KMR    1RG3    1RG4    1SSZ    2DWF    2JOU    2M0H    2M1T   
PDB (IMB)1DFW    1KMR    1RG3    1RG4    1SSZ    2DWF    2JOU    2M0H    2M1T   
Structural Biology KnowledgeBase1DFW    1KMR    1RG3    1RG4    1SSZ    2DWF    2JOU    2M0H    2M1T   
SCOP (Structural Classification of Proteins)1DFW    1KMR    1RG3    1RG4    1SSZ    2DWF    2JOU    2M0H    2M1T   
CATH (Classification of proteins structures)1DFW    1KMR    1RG3    1RG4    1SSZ    2DWF    2JOU    2M0H    2M1T   
SuperfamilyP07988
AlphaFold pdb e-kbP07988   
Human Protein Atlas [tissue]ENSG00000168878-SFTPB [tissue]
HPRD01523
Protein Interaction databases
DIP (DOE-UCLA)P07988
IntAct (EBI)P07988
BioGRIDSFTPB
STRING (EMBL)SFTPB
ZODIACSFTPB
Ontologies - Pathways
QuickGOP07988
Ontology : AmiGOprotein binding  extracellular region  extracellular space  lysosome  multivesicular body  endoplasmic reticulum membrane  sphingolipid metabolic process  respiratory gaseous exchange by respiratory system  animal organ morphogenesis  lamellar body  cellular protein metabolic process  clathrin-coated endocytic vesicle  alveolar lamellar body  multivesicular body lumen  
Ontology : EGO-EBIprotein binding  extracellular region  extracellular space  lysosome  multivesicular body  endoplasmic reticulum membrane  sphingolipid metabolic process  respiratory gaseous exchange by respiratory system  animal organ morphogenesis  lamellar body  cellular protein metabolic process  clathrin-coated endocytic vesicle  alveolar lamellar body  multivesicular body lumen  
NDEx NetworkSFTPB
Atlas of Cancer Signalling NetworkSFTPB
Wikipedia pathwaysSFTPB
Orthology - Evolution
OrthoDB6439
GeneTree (enSembl)ENSG00000168878
Phylogenetic Trees/Animal Genes : TreeFamSFTPB
Homologs : HomoloGeneSFTPB
Homology/Alignments : Family Browser (UCSC)SFTPB
Gene fusions - Rearrangements
Fusion : MitelmanSFTPA2/SFTPB [10q22.3/2p11.2]  
Fusion : MitelmanSFTPB/DPYSL2 [2p11.2/8p21.2]  
Fusion Cancer (Beijing)BAG3 [10q26.11]  -  SFTPB [2p11.2]  [FUSC003619]
Fusion Cancer (Beijing)DNAH2 [17p13.1]  -  SFTPB [2p11.2]  [FUSC003538]
Fusion Cancer (Beijing)EML3 [11q12.3]  -  SFTPB [2p11.2]  [FUSC002628]
Fusion Cancer (Beijing)EPOR [19p13.2]  -  SFTPB [2p11.2]  [FUSC003071]
Fusion Cancer (Beijing)FAM53B [10q26.13]  -  SFTPB [2p11.2]  [FUSC002990]
Fusion Cancer (Beijing)GRN [17q21.31]  -  SFTPB [2p11.2]  [FUSC002741]
Fusion Cancer (Beijing)KCNK2 [1q41]  -  SFTPB [2p11.2]  [FUSC003079]
Fusion Cancer (Beijing)KHNYN [14q12]  -  SFTPB [2p11.2]  [FUSC002998]
Fusion Cancer (Beijing)LARP6 [15q23]  -  SFTPB [2p11.2]  [FUSC003635]
Fusion Cancer (Beijing)NEUROD2 [17q12]  -  SFTPB [2p11.2]  [FUSC003644]  [FUSC003644]
Fusion Cancer (Beijing)ODF3L1 [15q24.2]  -  SFTPB [2p11.2]  [FUSC003647]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  AMOTL2 [3q22.2]  [FUSC003022]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  BRP44L [FUSC003396]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  FKBP9 [7p14.3]  [FUSC003300]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  FOXP2 [7q31.1]  [FUSC003657]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  HMGB3 [Xq28]  [FUSC003659]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  HNF4A [20q13.12]  [FUSC002436]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  LOC284798 [20p11.21]  [FUSC002776]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  LPP [3q28]  [FUSC002777]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  MSN [Xq12]  [FUSC003661]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  NCOA5 [20q13.12]  [FUSC003662]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  RPS6KA2 [6q27]  [FUSC003304]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  SNRPC [6p21.31]  [FUSC003275]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  SOX30 [5q33.3]  [FUSC003666]
Fusion Cancer (Beijing)SLC25A24 [1p13.3]  -  SFTPB [2p11.2]  [FUSC003669]
Fusion Cancer (Beijing)SRSF10 [1p36.11]  -  SFTPB [2p11.2]  [FUSC003117]
Fusion Cancer (Beijing)STARD9 [15q15.2]  -  SFTPB [2p11.2]  [FUSC003671]
Fusion Cancer (Beijing)UBA2 [19q13.11]  -  SFTPB [2p11.2]  [FUSC002787]
Fusion Cancer (Beijing)WFIKKN2 [17q21.33]  -  SFTPB [2p11.2]  [FUSC003045]
Fusion Cancer (Beijing)ZNF281 [1q32.1]  -  SFTPB [2p11.2]  [FUSC003310]
Fusion : QuiverSFTPB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSFTPB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SFTPB
dbVarSFTPB
ClinVarSFTPB
MonarchSFTPB
1000_GenomesSFTPB 
Exome Variant ServerSFTPB
GNOMAD BrowserENSG00000168878
Varsome BrowserSFTPB
ACMGSFTPB variants
VarityP07988
Genomic Variants (DGV)SFTPB [DGVbeta]
DECIPHERSFTPB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSFTPB 
Mutations
ICGC Data PortalSFTPB 
TCGA Data PortalSFTPB 
Broad Tumor PortalSFTPB
OASIS PortalSFTPB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSFTPB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSFTPB
Mutations and Diseases : HGMDSFTPB
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSFTPB
DgiDB (Drug Gene Interaction Database)SFTPB
DoCM (Curated mutations)SFTPB
CIViC (Clinical Interpretations of Variants in Cancer)SFTPB
Cancer3DSFTPB
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM178640    265120   
Orphanet18862    10958   
DisGeNETSFTPB
MedgenSFTPB
Genetic Testing Registry SFTPB
NextProtP07988 [Medical]
GENETestsSFTPB
Target ValidationSFTPB
Huge Navigator SFTPB [HugePedia]
ClinGenSFTPB
Clinical trials, drugs, therapy
MyCancerGenomeSFTPB
Protein Interactions : CTDSFTPB
Pharm GKB GenePA35713
PharosP07988
Clinical trialSFTPB
Miscellaneous
canSAR (ICR)SFTPB
HarmonizomeSFTPB
DataMed IndexSFTPB
Probes
Litterature
PubMed150 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSFTPB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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