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SGIP1 (SH3 domain GRB2 like endophilin interacting protein 1)

Identity

Alias_symbol (synonym)DKFZp761D221
Other alias-
HGNC (Hugo) SGIP1
LocusID (NCBI) 84251
Atlas_Id 73182
Location 1p31.3  [Link to chromosome band 1p31]
Location_base_pair Starts at 66533569 and ends at 66751139 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ELOVL5 (6p12.1) / SGIP1 (1p31.3)GSK3B (3q13.33) / SGIP1 (1p31.3)SGIP1 (1p31.3) / CPLX4 (18q21.32)
SGIP1 (1p31.3) / DLGAP1 (18p11.31)SGIP1 (1p31.3) / SEC31B (10q24.31)TAMM41 (3p25.2) / SGIP1 (1p31.3)
USP1 (1p31.3) / SGIP1 (1p31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SGIP1   25412
Cards
Entrez_Gene (NCBI)SGIP1  84251  SH3 domain GRB2 like endophilin interacting protein 1
Aliases
GeneCards (Weizmann)SGIP1
Ensembl hg19 (Hinxton)ENSG00000118473 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118473 [Gene_View]  chr1:66533569-66751139 [Contig_View]  SGIP1 [Vega]
ICGC DataPortalENSG00000118473
TCGA cBioPortalSGIP1
AceView (NCBI)SGIP1
Genatlas (Paris)SGIP1
WikiGenes84251
SOURCE (Princeton)SGIP1
Genetics Home Reference (NIH)SGIP1
Genomic and cartography
GoldenPath hg38 (UCSC)SGIP1  -     chr1:66533569-66751139 +  1p31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SGIP1  -     1p31.3   [Description]    (hg19-Feb_2009)
EnsemblSGIP1 - 1p31.3 [CytoView hg19]  SGIP1 - 1p31.3 [CytoView hg38]
Mapping of homologs : NCBISGIP1 [Mapview hg19]  SGIP1 [Mapview hg38]
OMIM611540   
Gene and transcription
Genbank (Entrez)AB210039 AK090697 AK125044 AK298970 AK299941
RefSeq transcript (Entrez)NM_001308203 NM_001350217 NM_001350218 NM_032291
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SGIP1
Cluster EST : UnigeneHs.159853 [ NCBI ]
CGAP (NCI)Hs.159853
Alternative Splicing GalleryENSG00000118473
Gene ExpressionSGIP1 [ NCBI-GEO ]   SGIP1 [ EBI - ARRAY_EXPRESS ]   SGIP1 [ SEEK ]   SGIP1 [ MEM ]
Gene Expression Viewer (FireBrowse)SGIP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84251
GTEX Portal (Tissue expression)SGIP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQI5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BQI5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BQI5
Splice isoforms : SwissVarQ9BQI5
PhosPhoSitePlusQ9BQI5
Domaine pattern : Prosite (Expaxy)MHD (PS51072)   
Domains : Interpro (EBI)MHD    Muniscin_C   
Domain families : Pfam (Sanger)muHD (PF10291)   
Domain families : Pfam (NCBI)pfam10291   
Conserved Domain (NCBI)SGIP1
DMDM Disease mutations84251
Blocks (Seattle)SGIP1
PDB (SRS)5AWR    5AWS    5AWT    5AWU   
PDB (PDBSum)5AWR    5AWS    5AWT    5AWU   
PDB (IMB)5AWR    5AWS    5AWT    5AWU   
PDB (RSDB)5AWR    5AWS    5AWT    5AWU   
Structural Biology KnowledgeBase5AWR    5AWS    5AWT    5AWU   
SCOP (Structural Classification of Proteins)5AWR    5AWS    5AWT    5AWU   
CATH (Classification of proteins structures)5AWR    5AWS    5AWT    5AWU   
SuperfamilyQ9BQI5
Human Protein AtlasENSG00000118473
Peptide AtlasQ9BQI5
HPRD10910
IPIIPI00031087   IPI00784625   IPI00217265   IPI00785188   IPI01011291   IPI00426076   IPI00953708   IPI00445827   IPI00647876   
Protein Interaction databases
DIP (DOE-UCLA)Q9BQI5
IntAct (EBI)Q9BQI5
FunCoupENSG00000118473
BioGRIDSGIP1
STRING (EMBL)SGIP1
ZODIACSGIP1
Ontologies - Pathways
QuickGOQ9BQI5
Ontology : AmiGOresponse to dietary excess  protein binding  phospholipid binding  cytoplasm  cytosol  plasma membrane  clathrin-coated pit  endocytosis  microtubule binding  SH3 domain binding  AP-2 adaptor complex  clathrin-coated vesicle  positive regulation of receptor-mediated endocytosis  membrane organization  plasma membrane tubulation  positive regulation of feeding behavior  positive regulation of energy homeostasis  
Ontology : EGO-EBIresponse to dietary excess  protein binding  phospholipid binding  cytoplasm  cytosol  plasma membrane  clathrin-coated pit  endocytosis  microtubule binding  SH3 domain binding  AP-2 adaptor complex  clathrin-coated vesicle  positive regulation of receptor-mediated endocytosis  membrane organization  plasma membrane tubulation  positive regulation of feeding behavior  positive regulation of energy homeostasis  
NDEx NetworkSGIP1
Atlas of Cancer Signalling NetworkSGIP1
Wikipedia pathwaysSGIP1
Orthology - Evolution
OrthoDB84251
GeneTree (enSembl)ENSG00000118473
Phylogenetic Trees/Animal Genes : TreeFamSGIP1
HOVERGENQ9BQI5
HOGENOMQ9BQI5
Homologs : HomoloGeneSGIP1
Homology/Alignments : Family Browser (UCSC)SGIP1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSGIP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SGIP1
dbVarSGIP1
ClinVarSGIP1
1000_GenomesSGIP1 
Exome Variant ServerSGIP1
ExAC (Exome Aggregation Consortium)SGIP1 (select the gene name)
Genetic variants : HAPMAP84251
Genomic Variants (DGV)SGIP1 [DGVbeta]
DECIPHERSGIP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSGIP1 
Mutations
ICGC Data PortalSGIP1 
TCGA Data PortalSGIP1 
Broad Tumor PortalSGIP1
OASIS PortalSGIP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSGIP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSGIP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SGIP1
DgiDB (Drug Gene Interaction Database)SGIP1
DoCM (Curated mutations)SGIP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SGIP1 (select a term)
intoGenSGIP1
Cancer3DSGIP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611540   
Orphanet
MedgenSGIP1
Genetic Testing Registry SGIP1
NextProtQ9BQI5 [Medical]
TSGene84251
GENETestsSGIP1
Target ValidationSGIP1
Huge Navigator SGIP1 [HugePedia]
snp3D : Map Gene to Disease84251
BioCentury BCIQSGIP1
ClinGenSGIP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84251
Chemical/Pharm GKB GenePA134909202
Clinical trialSGIP1
Miscellaneous
canSAR (ICR)SGIP1 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSGIP1
EVEXSGIP1
GoPubMedSGIP1
iHOPSGIP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:37:41 CEST 2017

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