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SGK2 (serum/glucocorticoid regulated kinase 2)

Identity

Alias_namesserum/glucocorticoid regulated kinase 2
Other aliasH-SGK2
dJ138B7.2
HGNC (Hugo) SGK2
LocusID (NCBI) 10110
Atlas_Id 43489
Location 20q13.12  [Link to chromosome band 20q13]
Location_base_pair Starts at 42193755 and ends at 42214273 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FAM53B (10q26.13) / SGK2 (20q13.12)NCOA3 (20q13.12) / SGK2 (20q13.12)FAM53B 10q26.13 / SGK2 20q13.12
NCOA3 20q13.12 / SGK2 20q13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SGK2   13900
LRG (Locus Reference Genomic)LRG_1050
Cards
Entrez_Gene (NCBI)SGK2  10110  serum/glucocorticoid regulated kinase 2
AliasesH-SGK2; dJ138B7.2
GeneCards (Weizmann)SGK2
Ensembl hg19 (Hinxton)ENSG00000101049 [Gene_View]  chr20:42193755-42214273 [Contig_View]  SGK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000101049 [Gene_View]  chr20:42193755-42214273 [Contig_View]  SGK2 [Vega]
ICGC DataPortalENSG00000101049
TCGA cBioPortalSGK2
AceView (NCBI)SGK2
Genatlas (Paris)SGK2
WikiGenes10110
SOURCE (Princeton)SGK2
Genetics Home Reference (NIH)SGK2
Genomic and cartography
GoldenPath hg19 (UCSC)SGK2  -     chr20:42193755-42214273 +  20q13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SGK2  -     20q13.12   [Description]    (hg38-Dec_2013)
EnsemblSGK2 - 20q13.12 [CytoView hg19]  SGK2 - 20q13.12 [CytoView hg38]
Mapping of homologs : NCBISGK2 [Mapview hg19]  SGK2 [Mapview hg38]
OMIM607589   
Gene and transcription
Genbank (Entrez)AF169034 AF186470 AK289596 AK308502 AY987010
RefSeq transcript (Entrez)NM_001199264 NM_016276 NM_170693
RefSeq genomic (Entrez)NC_000020 NC_018931 NG_029448 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)SGK2
Cluster EST : UnigeneHs.740147 [ NCBI ]
CGAP (NCI)Hs.740147
Alternative Splicing GalleryENSG00000101049
Gene ExpressionSGK2 [ NCBI-GEO ]   SGK2 [ EBI - ARRAY_EXPRESS ]   SGK2 [ SEEK ]   SGK2 [ MEM ]
Gene Expression Viewer (FireBrowse)SGK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10110
GTEX Portal (Tissue expression)SGK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HBY8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HBY8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HBY8
Splice isoforms : SwissVarQ9HBY8
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9HBY8
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00069    pfam00433   
Domain families : Smart (EMBL)S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)SGK2
DMDM Disease mutations10110
Blocks (Seattle)SGK2
SuperfamilyQ9HBY8
Human Protein AtlasENSG00000101049
Peptide AtlasQ9HBY8
HPRD06348
IPIIPI00009887   IPI00217154   IPI00853438   IPI00867534   IPI01014385   IPI00644787   IPI00827798   
Protein Interaction databases
DIP (DOE-UCLA)Q9HBY8
IntAct (EBI)Q9HBY8
FunCoupENSG00000101049
BioGRIDSGK2
STRING (EMBL)SGK2
ZODIACSGK2
Ontologies - Pathways
QuickGOQ9HBY8
Ontology : AmiGOregulation of cell growth  protein serine/threonine kinase activity  calcium channel regulator activity  ATP binding  cellular_component  intracellular  nucleus  cytosol  protein phosphorylation  cellular sodium ion homeostasis  response to oxidative stress  positive regulation of sodium ion transport  potassium channel regulator activity  sodium channel regulator activity  sodium channel regulator activity  chloride channel regulator activity  peptidyl-serine phosphorylation  positive regulation of transporter activity  ion transmembrane transport  intracellular signal transduction  regulation of cell proliferation  regulation of apoptotic process  
Ontology : EGO-EBIregulation of cell growth  protein serine/threonine kinase activity  calcium channel regulator activity  ATP binding  cellular_component  intracellular  nucleus  cytosol  protein phosphorylation  cellular sodium ion homeostasis  response to oxidative stress  positive regulation of sodium ion transport  potassium channel regulator activity  sodium channel regulator activity  sodium channel regulator activity  chloride channel regulator activity  peptidyl-serine phosphorylation  positive regulation of transporter activity  ion transmembrane transport  intracellular signal transduction  regulation of cell proliferation  regulation of apoptotic process  
Pathways : KEGGFoxO signaling pathway    PI3K-Akt signaling pathway   
NDEx NetworkSGK2
Atlas of Cancer Signalling NetworkSGK2
Wikipedia pathwaysSGK2
Orthology - Evolution
OrthoDB10110
GeneTree (enSembl)ENSG00000101049
Phylogenetic Trees/Animal Genes : TreeFamSGK2
HOVERGENQ9HBY8
HOGENOMQ9HBY8
Homologs : HomoloGeneSGK2
Homology/Alignments : Family Browser (UCSC)SGK2
Gene fusions - Rearrangements
Fusion : MitelmanFAM53B/SGK2 [10q26.13/20q13.12]  [t(10;20)(q26;q13)]  
Fusion : MitelmanNCOA3/SGK2 [20q13.12/20q13.12]  [t(20;20)(q13;q13)]  
Fusion: TCGAFAM53B 10q26.13 SGK2 20q13.12 BRCA
Fusion: TCGANCOA3 20q13.12 SGK2 20q13.12 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSGK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SGK2
dbVarSGK2
ClinVarSGK2
1000_GenomesSGK2 
Exome Variant ServerSGK2
ExAC (Exome Aggregation Consortium)SGK2 (select the gene name)
Genetic variants : HAPMAP10110
Genomic Variants (DGV)SGK2 [DGVbeta]
DECIPHER (Syndromes)20:42193755-42214273  ENSG00000101049
CONAN: Copy Number AnalysisSGK2 
Mutations
ICGC Data PortalSGK2 
TCGA Data PortalSGK2 
Broad Tumor PortalSGK2
OASIS PortalSGK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSGK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSGK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SGK2
DgiDB (Drug Gene Interaction Database)SGK2
DoCM (Curated mutations)SGK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SGK2 (select a term)
intoGenSGK2
Cancer3DSGK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607589   
Orphanet
MedgenSGK2
Genetic Testing Registry SGK2
NextProtQ9HBY8 [Medical]
TSGene10110
GENETestsSGK2
Huge Navigator SGK2 [HugePedia]
snp3D : Map Gene to Disease10110
BioCentury BCIQSGK2
ClinGenSGK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10110
Chemical/Pharm GKB GenePA37824
Clinical trialSGK2
Miscellaneous
canSAR (ICR)SGK2 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSGK2
EVEXSGK2
GoPubMedSGK2
iHOPSGK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:27:03 CET 2017

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