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SGK3 (serum/glucocorticoid regulated kinase family member 3)

Identity

Alias_namesSGK2
SGKL
serum/glucocorticoid regulated kinase-like
serum/glucocorticoid regulated kinase family, member 3
Other aliasCISK
HGNC (Hugo) SGK3
LocusID (NCBI) 23678
Atlas_Id 52187
Location 8q13.1  [Link to chromosome band 8q13]
Location_base_pair Starts at 66712418 and ends at 66862022 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C8orf44 (8q13.1) / SGK3 (8q13.1)SGK3 (8q13.1) / DNAJC5B (8q13.1)SGK3 (8q13.1) / KRT9 (17q21.2)
SGK3 (8q13.1) / TRIM55 (8q13.1)SGK3 8q13.1 / DNAJC5B 8q13.1SGK3 8q13.1 / KRT9 17q21.2
SGK3 8q13.1 / TRIM55 8q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SGK3   10812
Cards
Entrez_Gene (NCBI)SGK3  23678  serum/glucocorticoid regulated kinase family member 3
AliasesCISK; SGK2; SGKL
GeneCards (Weizmann)SGK3
Ensembl hg19 (Hinxton)ENSG00000104205 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104205 [Gene_View]  chr8:66712418-66862022 [Contig_View]  SGK3 [Vega]
ICGC DataPortalENSG00000104205
TCGA cBioPortalSGK3
AceView (NCBI)SGK3
Genatlas (Paris)SGK3
WikiGenes23678
SOURCE (Princeton)SGK3
Genetics Home Reference (NIH)SGK3
Genomic and cartography
GoldenPath hg38 (UCSC)SGK3  -     chr8:66712418-66862022 +  8q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SGK3  -     8q13.1   [Description]    (hg19-Feb_2009)
EnsemblSGK3 - 8q13.1 [CytoView hg19]  SGK3 - 8q13.1 [CytoView hg38]
Mapping of homologs : NCBISGK3 [Mapview hg19]  SGK3 [Mapview hg38]
OMIM607591   
Gene and transcription
Genbank (Entrez)AF085233 AF169035 AI127772 AK074666 AK223523
RefSeq transcript (Entrez)NM_001033578 NM_013257 NM_170709
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SGK3
Cluster EST : UnigeneHs.733251 [ NCBI ]
CGAP (NCI)Hs.733251
Alternative Splicing GalleryENSG00000104205
Gene ExpressionSGK3 [ NCBI-GEO ]   SGK3 [ EBI - ARRAY_EXPRESS ]   SGK3 [ SEEK ]   SGK3 [ MEM ]
Gene Expression Viewer (FireBrowse)SGK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23678
GTEX Portal (Tissue expression)SGK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96BR1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96BR1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96BR1
Splice isoforms : SwissVarQ96BR1
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ96BR1
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    PX (PS50195)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom    Phox    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    Pkinase_C (PF00433)    PX (PF00787)   
Domain families : Pfam (NCBI)pfam00069    pfam00433    pfam00787   
Domain families : Smart (EMBL)PX (SM00312)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)SGK3
DMDM Disease mutations23678
Blocks (Seattle)SGK3
SuperfamilyQ96BR1
Human Protein AtlasENSG00000104205
Peptide AtlasQ96BR1
HPRD06349
IPIIPI00655852   IPI00980498   IPI00335929   IPI00979915   IPI00974105   IPI00979215   IPI00973984   
Protein Interaction databases
DIP (DOE-UCLA)Q96BR1
IntAct (EBI)Q96BR1
FunCoupENSG00000104205
BioGRIDSGK3
STRING (EMBL)SGK3
ZODIACSGK3
Ontologies - Pathways
QuickGOQ96BR1
Ontology : AmiGOregulation of cell growth  protein kinase activity  protein serine/threonine kinase activity  calcium channel regulator activity  protein binding  ATP binding  early endosome  cytosol  protein phosphorylation  response to stress  potassium channel regulator activity  sodium channel regulator activity  chloride channel regulator activity  peptidyl-serine phosphorylation  regulation of cell migration  cytoplasmic vesicle  positive regulation of transporter activity  ion transmembrane transport  phosphatidylinositol binding  intracellular signal transduction  regulation of cell proliferation  regulation of apoptotic process  regulation of sequence-specific DNA binding transcription factor activity  recycling endosome  
Ontology : EGO-EBIregulation of cell growth  protein kinase activity  protein serine/threonine kinase activity  calcium channel regulator activity  protein binding  ATP binding  early endosome  cytosol  protein phosphorylation  response to stress  potassium channel regulator activity  sodium channel regulator activity  chloride channel regulator activity  peptidyl-serine phosphorylation  regulation of cell migration  cytoplasmic vesicle  positive regulation of transporter activity  ion transmembrane transport  phosphatidylinositol binding  intracellular signal transduction  regulation of cell proliferation  regulation of apoptotic process  regulation of sequence-specific DNA binding transcription factor activity  recycling endosome  
Pathways : KEGGFoxO signaling pathway    PI3K-Akt signaling pathway   
NDEx NetworkSGK3
Atlas of Cancer Signalling NetworkSGK3
Wikipedia pathwaysSGK3
Orthology - Evolution
OrthoDB23678
GeneTree (enSembl)ENSG00000104205
Phylogenetic Trees/Animal Genes : TreeFamSGK3
HOVERGENQ96BR1
HOGENOMQ96BR1
Homologs : HomoloGeneSGK3
Homology/Alignments : Family Browser (UCSC)SGK3
Gene fusions - Rearrangements
Fusion : MitelmanSGK3/DNAJC5B [8q13.1/8q13.1]  
Fusion : MitelmanSGK3/KRT9 [8q13.1/17q21.2]  [t(8;17)(q13;q21)]  
Fusion : MitelmanSGK3/TRIM55 [8q13.1/8q13.1]  [t(8;8)(q13;q13)]  
Fusion: TCGASGK3 8q13.1 DNAJC5B 8q13.1 OV
Fusion: TCGASGK3 8q13.1 KRT9 17q21.2 LUAD
Fusion: TCGASGK3 8q13.1 TRIM55 8q13.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSGK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SGK3
dbVarSGK3
ClinVarSGK3
1000_GenomesSGK3 
Exome Variant ServerSGK3
ExAC (Exome Aggregation Consortium)SGK3 (select the gene name)
Genetic variants : HAPMAP23678
Genomic Variants (DGV)SGK3 [DGVbeta]
DECIPHERSGK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSGK3 
Mutations
ICGC Data PortalSGK3 
TCGA Data PortalSGK3 
Broad Tumor PortalSGK3
OASIS PortalSGK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSGK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSGK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SGK3
DgiDB (Drug Gene Interaction Database)SGK3
DoCM (Curated mutations)SGK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SGK3 (select a term)
intoGenSGK3
Cancer3DSGK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607591   
Orphanet
MedgenSGK3
Genetic Testing Registry SGK3
NextProtQ96BR1 [Medical]
TSGene23678
GENETestsSGK3
Target ValidationSGK3
Huge Navigator SGK3 [HugePedia]
snp3D : Map Gene to Disease23678
BioCentury BCIQSGK3
ClinGenSGK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23678
Chemical/Pharm GKB GenePA35722
Clinical trialSGK3
Miscellaneous
canSAR (ICR)SGK3 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSGK3
EVEXSGK3
GoPubMedSGK3
iHOPSGK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:55:16 CEST 2017

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