SGPP2 (sphingosine-1-phosphate phosphatase 2)

2019-04-01 Affiliation

Identity

HGNC

SGPP2

LOCATION

2q36.1

LOCUSID

130367

ALIAS

SPP2,SPPase2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 130367
MIM: 612827
HGNC: 19953
Ensembl: ENSG00000163082

Variants:

dbSNP: 130367
ClinVar: 130367
TCGA: ENSG00000163082
COSMIC: SGPP2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000163082	ENST00000321276	Q8IWX5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Sphingolipid metabolism	KEGG	ko00600
Sphingolipid metabolism	KEGG	hsa00600
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Sphingolipid metabolism	REACTOME	R-HSA-428157
Sphingolipid de novo biosynthesis	REACTOME	R-HSA-1660661

References

Pubmed ID	Year	Title	Citations
12411432	2003	Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2.	50
17113265	2007	Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses.	47
24274704	2013	Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function.	5

Citation

Dessen P

SGPP2 (sphingosine-1-phosphate phosphatase 2)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57924/sgpp2