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SH2B2 (SH2B adaptor protein 2)

Identity

Alias_symbol (synonym)APS
Other alias
HGNC (Hugo) SH2B2
LocusID (NCBI) 10603
Atlas_Id 682
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 101928353 and ends at 101962178 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SH2B2   17381
Cards
Entrez_Gene (NCBI)SH2B2  10603  SH2B adaptor protein 2
AliasesAPS
GeneCards (Weizmann)SH2B2
Ensembl hg19 (Hinxton)ENSG00000160999 [Gene_View]  chr7:101928353-101962178 [Contig_View]  SH2B2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000160999 [Gene_View]  chr7:101928353-101962178 [Contig_View]  SH2B2 [Vega]
ICGC DataPortalENSG00000160999
TCGA cBioPortalSH2B2
AceView (NCBI)SH2B2
Genatlas (Paris)SH2B2
WikiGenes10603
SOURCE (Princeton)SH2B2
Genetics Home Reference (NIH)SH2B2
Genomic and cartography
GoldenPath hg19 (UCSC)SH2B2  -     chr7:101928353-101962178 +  7q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SH2B2  -     7q22.1   [Description]    (hg38-Dec_2013)
EnsemblSH2B2 - 7q22.1 [CytoView hg19]  SH2B2 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBISH2B2 [Mapview hg19]  SH2B2 [Mapview hg38]
OMIM605300   
Gene and transcription
Genbank (Entrez)AB000520 BF309652 BF434397 BI261466 CB053166
RefSeq transcript (Entrez)NM_020979
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_033220 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)SH2B2
Cluster EST : UnigeneHs.489448 [ NCBI ]
CGAP (NCI)Hs.489448
Alternative Splicing GalleryENSG00000160999
Gene ExpressionSH2B2 [ NCBI-GEO ]   SH2B2 [ EBI - ARRAY_EXPRESS ]   SH2B2 [ SEEK ]   SH2B2 [ MEM ]
Gene Expression Viewer (FireBrowse)SH2B2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10603
GTEX Portal (Tissue expression)SH2B2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14492   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14492  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14492
Splice isoforms : SwissVarO14492
PhosPhoSitePlusO14492
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    SH2 (PS50001)   
Domains : Interpro (EBI)PH_dom-like    PH_domain    Phe_ZIP    SH2    SH2B    SH2B2   
Domain families : Pfam (Sanger)PH (PF00169)    Phe_ZIP (PF08916)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00169    pfam08916    pfam00017   
Domain families : Smart (EMBL)PH (SM00233)  SH2 (SM00252)  
Conserved Domain (NCBI)SH2B2
DMDM Disease mutations10603
Blocks (Seattle)SH2B2
PDB (SRS)1Q2H   
PDB (PDBSum)1Q2H   
PDB (IMB)1Q2H   
PDB (RSDB)1Q2H   
Structural Biology KnowledgeBase1Q2H   
SCOP (Structural Classification of Proteins)1Q2H   
CATH (Classification of proteins structures)1Q2H   
SuperfamilyO14492
Human Protein AtlasENSG00000160999
Peptide AtlasO14492
HPRD16097
IPIIPI01015259   IPI00155706   IPI00879791   
Protein Interaction databases
DIP (DOE-UCLA)O14492
IntAct (EBI)O14492
FunCoupENSG00000160999
BioGRIDSH2B2
STRING (EMBL)SH2B2
ZODIACSH2B2
Ontologies - Pathways
QuickGOO14492
Ontology : AmiGOsignal transducer activity  SH3/SH2 adaptor activity  protein binding  cytoplasm  cytosol  plasma membrane  signal transduction  blood coagulation  JAK pathway signal transduction adaptor activity  insulin receptor signaling pathway  positive regulation of signal transduction  positive regulation of signal transduction  intracellular signal transduction  regulation of JAK-STAT cascade  
Ontology : EGO-EBIsignal transducer activity  SH3/SH2 adaptor activity  protein binding  cytoplasm  cytosol  plasma membrane  signal transduction  blood coagulation  JAK pathway signal transduction adaptor activity  insulin receptor signaling pathway  positive regulation of signal transduction  positive regulation of signal transduction  intracellular signal transduction  regulation of JAK-STAT cascade  
Pathways : KEGGNeurotrophin signaling pathway    Insulin signaling pathway   
NDEx NetworkSH2B2
Atlas of Cancer Signalling NetworkSH2B2
Wikipedia pathwaysSH2B2
Orthology - Evolution
OrthoDB10603
GeneTree (enSembl)ENSG00000160999
Phylogenetic Trees/Animal Genes : TreeFamSH2B2
HOVERGENO14492
HOGENOMO14492
Homologs : HomoloGeneSH2B2
Homology/Alignments : Family Browser (UCSC)SH2B2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSH2B2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SH2B2
dbVarSH2B2
ClinVarSH2B2
1000_GenomesSH2B2 
Exome Variant ServerSH2B2
ExAC (Exome Aggregation Consortium)SH2B2 (select the gene name)
Genetic variants : HAPMAP10603
Genomic Variants (DGV)SH2B2 [DGVbeta]
DECIPHER (Syndromes)7:101928353-101962178  ENSG00000160999
CONAN: Copy Number AnalysisSH2B2 
Mutations
ICGC Data PortalSH2B2 
TCGA Data PortalSH2B2 
Broad Tumor PortalSH2B2
OASIS PortalSH2B2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSH2B2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSH2B2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SH2B2
DgiDB (Drug Gene Interaction Database)SH2B2
DoCM (Curated mutations)SH2B2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SH2B2 (select a term)
intoGenSH2B2
Cancer3DSH2B2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605300   
Orphanet
MedgenSH2B2
Genetic Testing Registry SH2B2
NextProtO14492 [Medical]
TSGene10603
GENETestsSH2B2
Huge Navigator SH2B2 [HugePedia]
snp3D : Map Gene to Disease10603
BioCentury BCIQSH2B2
ClinGenSH2B2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10603
Chemical/Pharm GKB GenePA145148106
Clinical trialSH2B2
Miscellaneous
canSAR (ICR)SH2B2 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSH2B2
EVEXSH2B2
GoPubMedSH2B2
iHOPSH2B2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:19:09 CEST 2017

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