SH2D1B (SH2 domain containing 1B)

2003-02-01  

Identity

HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
EAT2
FUSION GENES

Other Information

Locus ID:

NCBI: 117157
MIM: 608510
HGNC: 30416
Ensembl: ENSG00000198574

Variants:

dbSNP: 117157
ClinVar: 117157
TCGA: ENSG00000198574
COSMIC: SH2D1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198574ENST00000367929O14796

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Natural killer cell mediated cytotoxicityKEGGhsa04650
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
246879582014EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization.29
169209552006Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells.10
243747702014Manipulation of EAT-2 expression promotes induction of multiple beneficial regulatory and effector functions of the human innate immune system as a novel immunomodulatory strategy.5
275863002016The X-ray Crystallographic Structure of Human EAT2 (SH2D1B).1

Citation

Dessen P

SH2D1B (SH2 domain containing 1B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40390/sh2d1b