SH2D5 (SH2 domain containing 5)

2021-06-01 Affiliation

Identity

HGNC

SH2D5

LOCATION

1p36.12

LOCUSID

400745

ALIAS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 400745
HGNC: 28819
Ensembl: ENSG00000189410

Variants:

dbSNP: 400745
ClinVar: 400745
TCGA: ENSG00000189410
COSMIC: SH2D5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000189410	ENST00000375031	Q6ZV89
ENSG00000189410	ENST00000444387	Q6ZV89
ENSG00000189410	ENST00000447746	J3KQT6
ENSG00000189410	ENST00000517430	E5RGV2
ENSG00000189410	ENST00000518294	E5RJW5
ENSG00000189410	ENST00000519434	E5RGJ3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA445218	Pancreatic Neoplasms	Disease	ClinicalAnnotation	associated		PD	22838950
PA449748	gemcitabine	Chemical	ClinicalAnnotation	associated		PD	22838950

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
30659097	2019	Hepatitis B virus X protein-induced SH2 domain-containing 5 (SH2D5) expression promotes hepatoma cell growth via an SH2D5-transketolase interaction.	2

Citation

Dessen P

SH2D5 (SH2 domain containing 5)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58336/sh2d5