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SH3BGR (SH3 domain binding glutamate rich protein)

Identity

Alias_namesSH3 domain binding glutamic acid-rich protein
SH3 domain binding glutamate-rich protein
Alias_symbol (synonym)21-GARP
Other alias
HGNC (Hugo) SH3BGR
LocusID (NCBI) 6450
Atlas_Id 73197
Location 21q22.2  [Link to chromosome band 21q22]
Location_base_pair Starts at 39445871 and ends at 39515506 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DOPEY2 (21q22.12) / SH3BGR (21q22.2)PLCL2 (3p24.3) / SH3BGR (21q22.2)WRB (21q22.2) / SH3BGR (21q22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SH3BGR   10822
Cards
Entrez_Gene (NCBI)SH3BGR  6450  SH3 domain binding glutamate rich protein
Aliases21-GARP
GeneCards (Weizmann)SH3BGR
Ensembl hg19 (Hinxton)ENSG00000185437 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185437 [Gene_View]  chr21:39445871-39515506 [Contig_View]  SH3BGR [Vega]
ICGC DataPortalENSG00000185437
TCGA cBioPortalSH3BGR
AceView (NCBI)SH3BGR
Genatlas (Paris)SH3BGR
WikiGenes6450
SOURCE (Princeton)SH3BGR
Genetics Home Reference (NIH)SH3BGR
Genomic and cartography
GoldenPath hg38 (UCSC)SH3BGR  -     chr21:39445871-39515506 +  21q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SH3BGR  -     21q22.2   [Description]    (hg19-Feb_2009)
EnsemblSH3BGR - 21q22.2 [CytoView hg19]  SH3BGR - 21q22.2 [CytoView hg38]
Mapping of homologs : NCBISH3BGR [Mapview hg19]  SH3BGR [Mapview hg38]
OMIM602230   
Gene and transcription
Genbank (Entrez)AI338732 AW962501 BC006371 BG742101 BI819819
RefSeq transcript (Entrez)NM_001001713 NM_001317740 NM_001317741 NM_001317742 NM_007341
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SH3BGR
Cluster EST : UnigeneHs.473847 [ NCBI ]
CGAP (NCI)Hs.473847
Alternative Splicing GalleryENSG00000185437
Gene ExpressionSH3BGR [ NCBI-GEO ]   SH3BGR [ EBI - ARRAY_EXPRESS ]   SH3BGR [ SEEK ]   SH3BGR [ MEM ]
Gene Expression Viewer (FireBrowse)SH3BGR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6450
GTEX Portal (Tissue expression)SH3BGR
Human Protein AtlasENSG00000185437-SH3BGR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55822   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55822  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55822
Splice isoforms : SwissVarP55822
PhosPhoSitePlusP55822
Domains : Interpro (EBI)Glut_rich_SH3-bd    Thioredoxin-like_fold   
Domain families : Pfam (Sanger)SH3BGR (PF04908)   
Domain families : Pfam (NCBI)pfam04908   
Conserved Domain (NCBI)SH3BGR
DMDM Disease mutations6450
Blocks (Seattle)SH3BGR
SuperfamilyP55822
Human Protein Atlas [tissue]ENSG00000185437-SH3BGR [tissue]
Peptide AtlasP55822
HPRD03753
IPIIPI00026538   IPI00418589   IPI00657640   IPI01018271   IPI00925150   IPI00893869   IPI00924748   
Protein Interaction databases
DIP (DOE-UCLA)P55822
IntAct (EBI)P55822
FunCoupENSG00000185437
BioGRIDSH3BGR
STRING (EMBL)SH3BGR
ZODIACSH3BGR
Ontologies - Pathways
QuickGOP55822
Ontology : AmiGOSH3/SH2 adaptor activity  cytosol  protein complex assembly  positive regulation of signal transduction  SH3 domain binding  
Ontology : EGO-EBISH3/SH2 adaptor activity  cytosol  protein complex assembly  positive regulation of signal transduction  SH3 domain binding  
NDEx NetworkSH3BGR
Atlas of Cancer Signalling NetworkSH3BGR
Wikipedia pathwaysSH3BGR
Orthology - Evolution
OrthoDB6450
GeneTree (enSembl)ENSG00000185437
Phylogenetic Trees/Animal Genes : TreeFamSH3BGR
HOVERGENP55822
HOGENOMP55822
Homologs : HomoloGeneSH3BGR
Homology/Alignments : Family Browser (UCSC)SH3BGR
Gene fusions - Rearrangements
Fusion: Tumor Portal SH3BGR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSH3BGR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SH3BGR
dbVarSH3BGR
ClinVarSH3BGR
1000_GenomesSH3BGR 
Exome Variant ServerSH3BGR
ExAC (Exome Aggregation Consortium)ENSG00000185437
GNOMAD BrowserENSG00000185437
Genetic variants : HAPMAP6450
Genomic Variants (DGV)SH3BGR [DGVbeta]
DECIPHERSH3BGR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSH3BGR 
Mutations
ICGC Data PortalSH3BGR 
TCGA Data PortalSH3BGR 
Broad Tumor PortalSH3BGR
OASIS PortalSH3BGR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSH3BGR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSH3BGR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SH3BGR
DgiDB (Drug Gene Interaction Database)SH3BGR
DoCM (Curated mutations)SH3BGR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SH3BGR (select a term)
intoGenSH3BGR
Cancer3DSH3BGR(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602230   
Orphanet
MedgenSH3BGR
Genetic Testing Registry SH3BGR
NextProtP55822 [Medical]
TSGene6450
GENETestsSH3BGR
Target ValidationSH3BGR
Huge Navigator SH3BGR [HugePedia]
snp3D : Map Gene to Disease6450
BioCentury BCIQSH3BGR
ClinGenSH3BGR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6450
Chemical/Pharm GKB GenePA35730
Clinical trialSH3BGR
Miscellaneous
canSAR (ICR)SH3BGR (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSH3BGR
EVEXSH3BGR
GoPubMedSH3BGR
iHOPSH3BGR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:26:59 CET 2017

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