SH3BGRL (SH3 domain binding glutamate rich protein like)

2017-10-01  

Identity

HGNC
SH3BGRL
LOCATION
Xq21.1
LOCUSID
6451
ALIAS
HEL-S-115,SH3BGR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6451
MIM: 300190
HGNC: 10823
Ensembl: ENSG00000131171

Variants:

dbSNP: 6451
ClinVar: 6451
TCGA: ENSG00000131171
COSMIC: SH3BGRL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131171ENST00000373212O75368
ENSG00000131171ENST00000373212V9HW48

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
205322022010Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.34
161867992006The suppression of SH3BGRL is important for v-Rel-mediated transformation.14
264553182016Dual-faced SH3BGRL: oncogenic in mice, tumor suppressive in humans.8
160801462005Crystal structure of human SH3BGRL protein: the first structure of the human SH3BGR family representing a novel class of thioredoxin fold proteins.4
286792932018SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia.3

Citation

Dessen P

SH3BGRL (SH3 domain binding glutamate rich protein like)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57176/sh3bgrl