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SH3BGRL3 (SH3 domain binding glutamate rich protein like 3)

Identity

Alias_namesSH3 domain binding glutamic acid-rich protein like 3
Other aliasHEL-S-297
SH3BP-1
TIP-B1
HGNC (Hugo) SH3BGRL3
LocusID (NCBI) 83442
Atlas_Id 56502
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 26279722 and ends at 26281522 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADCY2 (5p15.31) / SH3BGRL3 (1p36.11)NOP16 (5q35.2) / SH3BGRL3 (1p36.11)PITX1 (5q31.1) / SH3BGRL3 (1p36.11)
SH3BGRL3 (1p36.11) / APP (21q21.3)SH3BGRL3 (1p36.11) / BTF3 (5q13.2)SH3BGRL3 (1p36.11) / DYNC1H1 (14q32.31)
SH3BGRL3 (1p36.11) / HCRTR1 (1p35.2)SH3BGRL3 (1p36.11) / IQGAP1 (15q26.1)SH3BGRL3 (1p36.11) / NOP16 (5q35.2)
SH3BGRL3 (1p36.11) / TPM3 (1q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SH3BGRL3   15568
Cards
Entrez_Gene (NCBI)SH3BGRL3  83442  SH3 domain binding glutamate rich protein like 3
AliasesHEL-S-297; SH3BP-1; TIP-B1
GeneCards (Weizmann)SH3BGRL3
Ensembl hg19 (Hinxton)ENSG00000142669 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142669 [Gene_View]  chr1:26279722-26281522 [Contig_View]  SH3BGRL3 [Vega]
ICGC DataPortalENSG00000142669
TCGA cBioPortalSH3BGRL3
AceView (NCBI)SH3BGRL3
Genatlas (Paris)SH3BGRL3
WikiGenes83442
SOURCE (Princeton)SH3BGRL3
Genetics Home Reference (NIH)SH3BGRL3
Genomic and cartography
GoldenPath hg38 (UCSC)SH3BGRL3  -     chr1:26279722-26281522 +  1p36.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SH3BGRL3  -     1p36.11   [Description]    (hg19-Feb_2009)
EnsemblSH3BGRL3 - 1p36.11 [CytoView hg19]  SH3BGRL3 - 1p36.11 [CytoView hg38]
Mapping of homologs : NCBISH3BGRL3 [Mapview hg19]  SH3BGRL3 [Mapview hg38]
OMIM615679   
Gene and transcription
Genbank (Entrez)AF247790 AF304163 AF466367 AJ297915 AK024884
RefSeq transcript (Entrez)NM_031286
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SH3BGRL3
Cluster EST : UnigeneHs.109051 [ NCBI ]
CGAP (NCI)Hs.109051
Alternative Splicing GalleryENSG00000142669
Gene ExpressionSH3BGRL3 [ NCBI-GEO ]   SH3BGRL3 [ EBI - ARRAY_EXPRESS ]   SH3BGRL3 [ SEEK ]   SH3BGRL3 [ MEM ]
Gene Expression Viewer (FireBrowse)SH3BGRL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83442
GTEX Portal (Tissue expression)SH3BGRL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H299   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H299  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H299
Splice isoforms : SwissVarQ9H299
PhosPhoSitePlusQ9H299
Domaine pattern : Prosite (Expaxy)GLUTAREDOXIN_2 (PS51354)   
Domains : Interpro (EBI)Glut_rich_SH3-bd    Glutaredoxin    Thioredoxin-like_fold   
Domain families : Pfam (Sanger)SH3BGR (PF04908)   
Domain families : Pfam (NCBI)pfam04908   
Conserved Domain (NCBI)SH3BGRL3
DMDM Disease mutations83442
Blocks (Seattle)SH3BGRL3
PDB (SRS)1SJ6   
PDB (PDBSum)1SJ6   
PDB (IMB)1SJ6   
PDB (RSDB)1SJ6   
Structural Biology KnowledgeBase1SJ6   
SCOP (Structural Classification of Proteins)1SJ6   
CATH (Classification of proteins structures)1SJ6   
SuperfamilyQ9H299
Human Protein AtlasENSG00000142669
Peptide AtlasQ9H299
HPRD15332
IPIIPI00746352   IPI00010402   IPI00514669   
Protein Interaction databases
DIP (DOE-UCLA)Q9H299
IntAct (EBI)Q9H299
FunCoupENSG00000142669
BioGRIDSH3BGRL3
STRING (EMBL)SH3BGRL3
ZODIACSH3BGRL3
Ontologies - Pathways
QuickGOQ9H299
Ontology : AmiGOGTPase activator activity  cytoplasm  electron carrier activity  protein disulfide oxidoreductase activity  nuclear body  lamellipodium  semaphorin receptor binding  regulation of actin filament depolymerization  regulation of actin cytoskeleton organization  regulation of blood vessel endothelial cell migration  positive regulation of GTPase activity  cell redox homeostasis  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIGTPase activator activity  cytoplasm  electron carrier activity  protein disulfide oxidoreductase activity  nuclear body  lamellipodium  semaphorin receptor binding  regulation of actin filament depolymerization  regulation of actin cytoskeleton organization  regulation of blood vessel endothelial cell migration  positive regulation of GTPase activity  cell redox homeostasis  oxidation-reduction process  extracellular exosome  
NDEx NetworkSH3BGRL3
Atlas of Cancer Signalling NetworkSH3BGRL3
Wikipedia pathwaysSH3BGRL3
Orthology - Evolution
OrthoDB83442
GeneTree (enSembl)ENSG00000142669
Phylogenetic Trees/Animal Genes : TreeFamSH3BGRL3
HOVERGENQ9H299
HOGENOMQ9H299
Homologs : HomoloGeneSH3BGRL3
Homology/Alignments : Family Browser (UCSC)SH3BGRL3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSH3BGRL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SH3BGRL3
dbVarSH3BGRL3
ClinVarSH3BGRL3
1000_GenomesSH3BGRL3 
Exome Variant ServerSH3BGRL3
ExAC (Exome Aggregation Consortium)SH3BGRL3 (select the gene name)
Genetic variants : HAPMAP83442
Genomic Variants (DGV)SH3BGRL3 [DGVbeta]
DECIPHERSH3BGRL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSH3BGRL3 
Mutations
ICGC Data PortalSH3BGRL3 
TCGA Data PortalSH3BGRL3 
Broad Tumor PortalSH3BGRL3
OASIS PortalSH3BGRL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSH3BGRL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSH3BGRL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SH3BGRL3
DgiDB (Drug Gene Interaction Database)SH3BGRL3
DoCM (Curated mutations)SH3BGRL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SH3BGRL3 (select a term)
intoGenSH3BGRL3
Cancer3DSH3BGRL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615679   
Orphanet
MedgenSH3BGRL3
Genetic Testing Registry SH3BGRL3
NextProtQ9H299 [Medical]
TSGene83442
GENETestsSH3BGRL3
Target ValidationSH3BGRL3
Huge Navigator SH3BGRL3 [HugePedia]
snp3D : Map Gene to Disease83442
BioCentury BCIQSH3BGRL3
ClinGenSH3BGRL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83442
Chemical/Pharm GKB GenePA37979
Clinical trialSH3BGRL3
Miscellaneous
canSAR (ICR)SH3BGRL3 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSH3BGRL3
EVEXSH3BGRL3
GoPubMedSH3BGRL3
iHOPSH3BGRL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:30:55 CEST 2017

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